Wisden, William - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

Neuroscience: molecular biology; transgenics, neuroanatomy, physiology, behaviour. Mechanisms of sleep Hypothalamic function: the regulation of neurons which make histamine: the tuberomammillary nucleus and sleep regulation other neuromodulators which regulate sleep

近期论文

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Wisden W, A tribute to Peter H Seeburg (1944-2016): a founding father of molecular neurobiology, Frontiers in Neuroscience, ISSN: 1662-4548 Leppa E, Linden A-M, Aller MI, Wulff P, Vekovischeva O, Luscher B, Lueddens H, Wisden W, Korpi ERet al., 2016, Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor gamma 2 Subunit in the Cerebellum, FRONTIERS IN PHARMACOLOGY, Vol: 7, ISSN: 1663-9812 Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden Wet al., 2016, Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons., J Neurosci, Vol: 36, Pages: 11171-11184 Wisden W, Yu X, Ye Z, Houston C, Vyssotski AL, Brickley SG, Franks NPet al., 2016, Histamine and gamma-amino butyric acid co-transmission promotes arousal, 23rd Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL, Pages: 26-26, ISSN: 0962-1105 Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden Wet al., 2015, The role of K-2P channels in anaesthesia and sleep, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 467, Pages: 907-916, ISSN: 0031-6768 Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden Wet al., 2015, Wakefulness Is Governed by GABA and Histamine Cotransmission, NEURON, Vol: 87, Pages: 164-178, ISSN: 0896-6273 Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden Wet al., 2015, A LOCAL CIRCADIAN CLOCK IN HISTAMINERGIC NEURONS INFLUENCES SLEEP ARCHITECTURE, 44th Annual Meeting of the European-Histamine-Research-Society (EHRS), Publisher: SPRINGER BASEL AG, Pages: S20-S20, ISSN: 1023-3830 Zhang Z, Ferretti V, Guentan I, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NPet al., 2015, Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha(2) adrenergic agonists, Nature Neuroscience, Vol: 18, Pages: 553-561, ISSN: 1546-1726 Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NPet al., 2014, Altered Activity in the Central Medial Thalamus Precedes Changes in the Neocortex during Transitions into Both Sleep and Propofol Anesthesia, JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 13326-13335, ISSN: 0270-6474 Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DWU, Vyssotski AL, van Lith HA, Wisden W, Franks NPet al., 2014, Staying awake - a genetic region that hinders alpha(2) adrenergic receptor agonist-induced sleep, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 40, Pages: 2311-2319, ISSN: 0953-816X Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden Wet al., 2014, Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture, CURRENT BIOLOGY, Vol: 24, Pages: 2838-2844, ISSN: 0960-9822 Frola E, Patrizi A, Goetz T, Medrihan L, Petrini EM, Barberis A, Wulff P, Wisden W, Sassoe-Pognetto Met al., 2013, Synaptic Competition Sculpts the Development of GABAergic Axo-Dendritic but Not Perisomatic Synapses, PLOS ONE, Vol: 8, ISSN: 1932-6203 Galliano E, Potters J-W, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FEet al., 2013, Synaptic Transmission and Plasticity at Inputs to Murine Cerebellar Purkinje Cells Are Largely Dispensable for Standard Nonmotor Tasks, JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 12599-12618, ISSN: 0270-6474 Franks N, Brickley S, Wisden W, 2012, The relationship between natural sleep and general anaesthesia, 21st Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL, Pages: 47-47, ISSN: 0962-1105 Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Huebner CA, De Zeeuw CI, Jentsch TJet al., 2012, Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning, EMBO JOURNAL, Vol: 31, Pages: 1217-1230, ISSN: 0261-4189 Zecharia AY, Yu X, Goetz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden Wet al., 2012, GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep-Wake Switch or Propofol-Induced Loss of Consciousness, JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 13062-U368, ISSN: 0270-6474 Engelhardt T, Wisden W, 2011, Central nervous system: neurotransmitters and anesthesia, Pediatric Anesthesia: Basic principles - state of the art - future, Editors: Bissonnette, Anderson, Boesenberg, Engelhardt, Mason, Tobias, Shelton, Connecticut, USA, Publisher: People's Medical publishing House -USA, Pages: 71-79, ISBN: 978-1-60795-093-6 Leppa E, Linden A-M, Rabe H, Vekovischeva OY, Wulff P, Lueddens H, Wisden W, Korpi ERet al., 2011, Actions of two GABA(A) receptor benzodiazepine-site ligands that are mediated via non-gamma 2-dependent modulation, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 666, Pages: 111-121, ISSN: 0014-2999 Leppa E, Linden A-M, Vekovischeva OY, Swinny JD, Rantanen V, Toppila E, Hoeger H, Sieghart W, Wulff P, Wisden W, Korpi ERet al., 2011, Removal of GABA(A) Receptor gamma 2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations, PLOS ONE, Vol: 6, ISSN: 1932-6203 Linden A-M, Schmitt U, Leppa E, Wulff P, Wisden W, Lueddens H, Korpi ERet al., 2011, Ro 15-4513 antagonizes alcohol-induced sedation in mice through alpha beta gamma 2-type GABA(A) receptors, FRONTIERS IN NEUROSCIENCE, Vol: 5, ISSN: 1662-453X