Thor, Jaspervan - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

We work on the structural dynamics of light sensitive proteins, using primarily ultrafast pump-probe techniques. Ultrafast crystallography and ultrafast spectroscopy are the main experimental techniques used. The research focuses on the cascading structural transformations that occur on multiple time scales ranging from femtoseconds to much longer, including structural rearrangements of meta-stable intermediates. We investigate reaction dynamics in light sensitive systems, including Fluorescent Proteins, Photosynthesis, and photoreceptor proteins such as Phytochromes and the Photoactive Yellow Protein

近期论文

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Kaucikas M, Maghlaoui K, barber J, Renger T, van Thor Jet al., Ultrafast infrared observation of exciton equilibration from oriented single crystals of photosystem II, Nature Communications, ISSN: 2041-1723 Hutchison CDM, Kaucikas M, Tenboer J, Kupitz C, Moffat K, Schmidt M, van Thor JJet al., 2016, Photocycle populations with femtosecond excitation of crystalline photoactive yellow protein, CHEMICAL PHYSICS LETTERS, Vol: 654, Pages: 63-71, ISSN: 0009-2614 Kim TW, Yang C, Kim Y, Kim JG, Kim J, Jung YO, Jun S, Lee SJ, Park S, Kosheleva I, Henning R, van Thore JJ, Ihee Het al., 2016, Combined probes of X-ray scattering and optical spectroscopy reveal how global conformational change is temporally and spatially linked to local structural perturbation in photoactive yellow protein, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 18, Pages: 8911-8919, ISSN: 1463-9076 Pande K, Hutchison CDM, Groenhof G, Aquila A, Robinson JS, Tenboer J, Basu S, Boutet S, DePonte DP, Liang M, White TA, Zatsepin NA, Yefanov O, Morozov D, Oberthuer D, Gati C, Subramanian G, James D, Zhao Y, Koralek J, Brayshaw J, Kupitz C, Conrad C, Roy-Chowdhury S, Coe JD, Metz M, Xavier PL, Grant TD, Koglin JE, Ketawala G, Fromme R, Srajer V, Henning R, Spence JCH, Ourmazd A, Schwander P, Weierstall U, Frank M, Fromme P, Barty A, Chapman HN, Moffat K, van Thor JJ, Schmidt Met al., 2016, Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein, SCIENCE, Vol: 352, Pages: 725-729, ISSN: 0036-8075 Salna B, Benabbas A, Sage JT, van Thor J, Champion PMet al., 2016, Wide-dynamic-range kinetic investigations of deep proton tunnelling in proteins, NATURE CHEMISTRY, Vol: 8, Pages: 874-880, ISSN: 1755-4330 Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJet al., 2015, Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, Vol: 83, Pages: 397-402, ISSN: 0887-3585 Kaucikas M, Tros M, van Thor JJ, 2015, Photoisomerization and Proton Transfer in the Forward and Reverse Photoswitching of the Fast-Switching M159T Mutant of the Dronpa Fluorescent Protein, JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 119, Pages: 2350-2362, ISSN: 1520-6106 van Thor JJ, Madsen A, 2015, A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography, STRUCTURAL DYNAMICS, Vol: 2, ISSN: 2329-7778 van Wilderen LJGW, Silkstone G, Mason M, van Thor JJ, Wilson MTet al., 2015, Kinetic studies on the oxidation of semiquinone and hydroquinone forms of Arabidopsis cryptochrome by molecular oxygen, FEBS OPEN BIO, Vol: 5, Pages: 885-892, ISSN: 2211-5463 Tenboer J, Basu S, Zatsepin N, Pande K, Milathianaki D, Frank M, Hunter M, Boutet S, Williams GJ, Koglin JE, Oberthuer D, Heymann M, Kupitz C, Conrad C, Coe J, Roy-Chowdhury S, Weierstall U, James D, Wang D, Grant T, Barty A, Yefanov O, Scales J, Gati C, Seuring C, Srajer V, Henning R, Schwander P, Fromme R, Ourmazd A, Moffat K, Van Thor JJ, Spence JCH, Fromme P, Chapman HN, Schmidt Met al., 2014, Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein, SCIENCE, Vol: 346, Pages: 1242-1246, ISSN: 0036-8075 Thompson LM, Champion PM, Sage JT, Frisch MJ, van Thor JJ, Bearpark MJet al., 2014, Analytical harmonic vibrational frequencies for the green fluorescent protein computed with ONIOM: Chromophore mode character and its response to environment, 247th National Spring Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 Thompson LM, Lasoroski A, Champion PM, Sage JT, Frisch MJ, van Thor JJ, Bearpark MJet al., 2014, Analytical Harmonic Vibrational Frequencies for the Green Fluorescent Protein Computed with ONIOM: Chromophore Mode Character and Its Response to Environment, JOURNAL OF CHEMICAL THEORY AND COMPUTATION, Vol: 10, Pages: 751-766, ISSN: 1549-9618 van Thor JJ, Warren MM, Lincoln CN, Chollet M, Lemke HT, Fritz DM, Schmidt M, Tenboer J, Ren Z, Srajer V, Moffat K, Graber Tet al., 2014, Signal to noise considerations for single crystal femtosecond time resolved crystallography of the Photoactive Yellow Protein, FARADAY DISCUSSIONS, Vol: 171, Pages: 439-455, ISSN: 1359-6640 Juozapavicius M, Kaucikas M, Dimitrov SD, Barnes PRF, van Thor JJ, O'Regan BCet al., 2013, Evidence for "Slow" Electron Injection in Commercially Relevant Dye-Sensitized Solar Cells by vis-NIR and IR Pump-Probe Spectroscopy, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 117, Pages: 25317-25324, ISSN: 1932-7447 Juozapavicius M, Kaucikas M, van Thor JJ, O'Regan BCet al., 2013, Observation of Multiexponential Pico- to Subnanosecond Electron Injection in Optimized Dye-Sensitized Solar Cells with Visible-Pump Mid-Infrared-Probe Transient Absorption Spectroscopy, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 117, Pages: 116-123, ISSN: 1932-7447 Kaucikas M, Barber J, Van Thor JJ, 2013, Polarization sensitive ultrafast mid-IR pump probe micro-spectrometer with diffraction limited spatial resolution, OPTICS EXPRESS, Vol: 21, Pages: 8357-8370, ISSN: 1094-4087 Kaucikas M, Warren M, Michailovas A, Antanavicius R, van Thor JJet al., 2013, Beam patterns in an optical parametric oscillator set-up employing walk-off compensating beta barium borate crystals, LASER PHYSICS, Vol: 23, ISSN: 1054-660X Kim TW, Lee JH, Choi J, Kim KH, van Wilderen LGW, Guerin L, Kim Y, Yung YO, Yang C, Kim J, Wulff M, van Thor JJ, Ihee Het al., 2013, Unravelling the protein structural dynamics of photoactive yellow protein in solution using pump-probe X-ray solution scattering Warren MM, Kaucikas M, Fitzpatrick A, Champion P, Sage JT, van Thor JJet al., 2013, Ground-state proton transfer in the photoswitching reactions of the fluorescent protein Dronpa, NATURE COMMUNICATIONS, Vol: 4, ISSN: 2041-1723 Fitzpatrick AE, Lincoln CN, van Wilderen LJGW, van Thor JJet al., 2012, Pump-Dump-Probe and Pump-Repump-Probe Ultrafast Spectroscopy Resolves Cross Section of an Early Ground State Intermediate and Stimulated Emission in the Photoreactions of the Pr Ground State of the Cyanobacterial Phytochrome Cph1, JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 116, Pages: 1077-1088, ISSN: 1520-6106