Sternberg, Michael - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

Professor Michael J. E. Sternberg is the Director of the Centre for Integrative Systems Biology and Bioinformatics (CISBIO) and holds the Chair of Structural Bioinformatics. CISBIO brings together scientists from a wide range of different fields to develop innovative interdisciplinary approaches to understanding biological problems. A key component of the interdisciplinary strategy is a repeated cycle of experimentation and modelling. Professor Sternberg has been involved in schools outreach programmes funded by the Royal Society and Rolls Royce. Professor Sternberg entered Bioinformatics via his D.Phil in Biophysics (Oxford). He obtained a first degree in Physics (Cambridge) and a Masters in Computing (Imperial College). He has worked at Oxford, Birkbeck College, Cancer Research UK and joined Imperial College in 2001.

研究领域

Prediction of protein structure and function Prediction of macromolecular docking and interactions Prediction of the effect of genetic variants particularlly those associate with disease Network modelling for Systems Biology Logic-based drug design

近期论文

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Howard SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE, Cabrera CP, Warren HR, Barnes MR, Quinton R, de Roux N, Young J, Guiochon-Mantel A, Wehkalampi K, Andre V, Gothilf Y, Cariboni A, Dunkel Let al., 2016, IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty, EMBO MOLECULAR MEDICINE, Vol: 8, Pages: 626-642, ISSN: 1757-4676 Mezulis S, Sternberg MJE, Kelley LA, 2016, PhyreStorm: A Web Server for Fast Structural Searches Against the PDB, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 702-708, ISSN: 0022-2836 Sternberg MJE, Ostankovitch MI, 2016, Computation Resources for Molecular Biology: A Special Issue, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 669-670, ISSN: 0022-2836 Cornish AJ, Filippis I, David A, Sternberg MJEet al., 2015, Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types, GENOME MEDICINE, Vol: 7, ISSN: 1756-994X David A, Sternberg MJ, 2015, The contribution of missense mutations in core and rim residues of protein-protein interfaces to human disease., Journal of Molecular Biology, Vol: 427, Pages: 2886-2898, ISSN: 1089-8638 Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJE, Lam EW-F, Fuchter MJet al., 2015, The Discovery of a Highly Selective 5,6,7,8-Tetrahydrobenzo[4,5]thieno[ 2,3-d] pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson's Disease Model, CHEMMEDCHEM, Vol: 10, Pages: 69-82, ISSN: 1860-7179 Greener JG, Sternberg MJE, 2015, AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis, BMC BIOINFORMATICS, Vol: 16, ISSN: 1471-2105 Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJet al., 2015, The Phyre2 web portal for protein modeling, prediction and analysis., Nature Protocols, Vol: 10, Pages: 845-858, ISSN: 1754-2189 Kelley LA, Sternberg MJ, 2015, Partial protein domains: evolutionary insights and bioinformatics challenges., Genome Biology, Vol: 16, Pages: 100-100, ISSN: 1474-760X Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DWA, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, Murzin AG, Ochoa-Montano B, Oates ME, Punta M, Rackham OJL, Stahlhacke J, Sternberg MJE, Velankar S, Orengo Cet al., 2015, Genome3D: exploiting structure to help users understand their sequences, NUCLEIC ACIDS RESEARCH, Vol: 43, Pages: D382-D386, ISSN: 0305-1048 Reynolds CR, Muggleton SH, Sternberg MJE, 2015, Incorporating Virtual Reactions into a Logic-based Ligand-based Virtual Screening Method to Discover New Leads, MOLECULAR INFORMATICS, Vol: 34, Pages: 615-625, ISSN: 1868-1743 Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallieres M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJE, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJet al., 2014, A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains, Cell, Vol: 159, Pages: 1511-1523, ISSN: 0092-8674 Talman AM, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN, Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJE, Christophides GK, Graham DR, Dinglasan RR, Yates JR, Sinden REet al., 2014, Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility, MALARIA JOURNAL, Vol: 13, ISSN: 1475-2875 Yates CM, Filippis I, Kelley LA, Sternberg MJEet al., 2014, SuSPect: Enhanced Prediction of Single Amino Acid Variant (SAV) Phenotype Using Network Features, JOURNAL OF MOLECULAR BIOLOGY, Vol: 426, Pages: 2692-2701, ISSN: 0022-2836 Adzhubei AA, Sternberg MJE, Makarov AA, 2013, Polyproline-II Helix in Proteins: Structure and Function, JOURNAL OF MOLECULAR BIOLOGY, Vol: 425, Pages: 2100-2132, ISSN: 0022-2836 Bryant WA, Sternberg MJE, Pinney JW, 2013, AMBIENT: Active Modules for Bipartite Networks - using high-throughput transcriptomic data to dissect metabolic response, BMC SYSTEMS BIOLOGY, Vol: 7, ISSN: 1752-0509 Janin J, Sternberg MJ, 2013, Protein flexibility, not disorder, is intrinsic to molecular recognition., F1000 Biol Rep, Vol: 5 Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DWA, Chothia C, Cuff A, Dana JM, Filippis I, Gough J, Hunter S, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mitchell A, Murzin AG, Ochoa-Montano B, Rackham OJL, Smith J, Sternberg MJE, Velankar S, Yeats C, Orengo Cet al., 2013, Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains, NUCLEIC ACIDS RESEARCH, Vol: 41, Pages: D499-D507, ISSN: 0305-1048 Mao C, Shukla M, Larrouy-Maumus G, Dix FL, Kelley LA, Sternberg MJ, Sobral BW, de Carvalho LPSet al., 2013, Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition, TUBERCULOSIS, Vol: 93, Pages: 40-46, ISSN: 1472-9792 Radivojac P, Clark WT, Oron TR, Schnoes AM, Wittkop T, Sokolov A, Graim K, Funk C, Verspoor K, Ben-Hur A, Pandey G, Yunes JM, Talwalkar AS, Repo S, Souza ML, Piovesan D, Casadio R, Wang Z, Cheng J, Fang H, Goughl J, Koskinen P, Toronen P, Nokso-Koivisto J, Holm L, Cozzetto D, Buchan DWA, Bryson K, Jones DT, Limaye B, Inamdar H, Datta A, Manjari SK, Joshi R, Chitale M, Kihara D, Lisewski AM, Erdin S, Venner E, Lichtarge O, Rentzsch R, Yang H, Romero AE, Bhat P, Paccanaro A, Hamp T, Kassner R, Seemayer S, Vicedo E, Schaefer C, Achten D, Auer F, Boehm A, Braun T, Hecht M, Heron M, Hoenigschmid P, Hopf TA, Kaufmann S, Kiening M, Krompass D, Landerer C, Mahlich Y, Roos M, Bjorne J, Salakoski T, Wong A, Shatkay H, Gatzmann F, Sommer I, Wass MN, Sternberg MJE, Skunca N, Supek F, Bosnjak M, Panov P, Dzeroski S, Smuc T, Kourmpetis YAI, van Dijk ADJ, ter Braak CJF, Zhou Y, Gong Q, Dong X, Tian W, Falda M, Fontana P, Lavezzo E, Di Camillo B, Toppo S, Lan L, Djuric N, Guo Y, Vucetic S, Bairoch A, Linial M, Babbitt PC, Brenner SE, Orengo C, Rost B, Mooney SD, Friedberg Iet al., 2013, A large-scale evaluation of computational protein function prediction, NATURE METHODS, Vol: 10, Pages: 221-227, ISSN: 1548-7091