Southall, Tony D. - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

I am interested in how neuronal properties are specified and maintained in the developing and adult nervous system. Gaining a comprehensive understanding of gene regulatory networks that specify neuronal fate will provide methods for reprogramming neuronal properties in vivo. This research utilises the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of transcriptional regulators, in specific neuronal populations.

近期论文

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Aughey GN, Southall TD, 2016, Dam it's good! DamID profiling of protein-DNA interactions, WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY, Vol: 5, Pages: 25-37, ISSN: 1759-7684 Cattenoz PB, Popkova A, Southall TD, Aiello G, Brand AH, Giangrande Aet al., 2016, Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila, GENETICS, Vol: 202, Pages: 191-+, ISSN: 0016-6731 Marshall OJ, Southall TD, Cheetham SW, Brand AHet al., 2016, Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing, NATURE PROTOCOLS, Vol: 11, Pages: 1586-1598, ISSN: 1754-2189 McClure CD, Southall TD, 2015, Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner, ADVANCES IN GENETICS, VOL 91, Vol: 91, Pages: 103-151, ISSN: 0065-2660 Korzelius J, Naumann SK, Loza-Coll MA, Chan JSK, Dutta D, Oberheim J, Glaesser C, Southall TD, Brand AH, Jones DL, Edgar BAet al., 2014, Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells, EMBO JOURNAL, Vol: 33, Pages: 2967-2982, ISSN: 0261-4189 Loza-Coll MA, Southall TD, Sandall SL, Brand AH, Jones DLet al., 2014, Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot, EMBO JOURNAL, Vol: 33, Pages: 2983-2996, ISSN: 0261-4189 Neville MC, Nojima T, Ashley E, Parker DJ, Walker J, Southall T, VandeSande B, Marques AC, Fischer B, Brand AH, Russell S, Ritchie MG, Aerts S, Goodwin SFet al., 2014, Male-Specific Fruitless Isoforms Target Neurodevelopmental Genes to Specify a Sexually Dimorphic Nervous System, Current Biology, Vol: 24, Pages: 229-241, ISSN: 0960-9822 Southall TD, Davidson CM, Miller C, Carr A, Brand AHet al., 2014, Dedifferentiation of Neurons Precedes Tumor Formation in lola Mutants, DEVELOPMENTAL CELL, Vol: 28, Pages: 685-696, ISSN: 1534-5807 Wolfram V, Southall TD, Guenay C, Prinz AA, Brand AH, Baines RAet al., 2014, The Transcription Factors Islet and Lim3 Combinatorially Regulate Ion Channel Gene Expression, JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 2538-2543, ISSN: 0270-6474 Southall TD, Gold KS, Egger B, Davidson CM, Caygill EE, Marshall OJ, Brand AHet al., 2013, Cell-Type-Specific Profiling of Gene Expression and Chromatin Binding without Cell Isolation: Assaying RNA Pol II Occupancy in Neural Stem Cells, DEVELOPMENTAL CELL, Vol: 26, Pages: 101-112, ISSN: 1534-5807 Murray MJ, Southall TD, Liu W, Fraval H, Lorensuhewa N, Brand AH, Saint Ret al., 2012, Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster, DEVELOPMENT GENES AND EVOLUTION, Vol: 222, Pages: 361-368, ISSN: 0949-944X Wolfram V, Southall TD, Brand AH, Baines RAet al., 2012, The LIM-Homeodomain Protein Islet Dictates Motor Neuron Electrical Properties by Regulating K+ Channel Expression, NEURON, Vol: 75, Pages: 663-674, ISSN: 0896-6273 Wolfram V, Southall TD, Brand AH, Baines RAet al., 2012, The homeodomain transcription factors islet and lim3 synergize to regulate sh expression in motoneurons, JOURNAL OF NEUROGENETICS, Vol: 26, Pages: 36-36, ISSN: 0167-7063 Bardin AJ, Perdigoto CN, Southall TD, Brand AH, Schweisguth Fet al., 2010, Transcriptional control of stem cell maintenance in the Drosophila intestine, DEVELOPMENT, Vol: 137, Pages: 705-714, ISSN: 0950-1991 Southall TD, Brand AH, 2009, Neural stem cell transcriptional networks highlight genes essential for nervous system development, EMBO JOURNAL, Vol: 28, Pages: 3799-3807, ISSN: 0261-4189 Southall TD, Brand AH, 2008, Generation of Driver and Reporter Constructs for the GAL4 Expression System in Drosophila., CSH Protoc, Vol: 2008 Southall TD, Egger B, Gold KS, Brand AHet al., 2008, Regulation of Self-renewal and Differentiation in the Drosophila Nervous System, 73rd Cold Spring Harbor Symposium on Quantitative Biology, Publisher: COLD SPRING HARBOR LABORATORY PRESS, Pages: 523-528, ISSN: 0091-7451 Southall TD, Elliott DA, Brand AH, 2008, The GAL4 System: A Versatile Toolkit for Gene Expression in Drosophila., CSH Protoc, Vol: 2008 Southall TD, Brand AH, 2007, Chromatin profiling in model organisms., Brief Funct Genomic Proteomic, Vol: 6, Pages: 133-140, ISSN: 1473-9550 Choksi SP, Southall TD, Bossing T, Edoff K, de Wit E, Fischer BE, van Steensel B, Micklem G, Brand AHet al., 2006, Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells, DEVELOPMENTAL CELL, Vol: 11, Pages: 775-789, ISSN: 1534-5807