Selkirk, Murray - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

Murray Selkirk earned his PhD at the National Institute for Medical Research, Mill Hill, where he studied immunosuppression in murine trypanosomiasis with Bridget Ogilvie. He then joined the University of Washington, Seattle, working with Nina Agabian on antigenic variation in trypanosomes, and after a brief spell at the Naval Biosciences Laboratory in Oakland, joined Rick Maizels at Imperial College, switching his attention to nematode parasites, in particular those responsible for lymphatic filariasis. He was appointed to a Lectureship in the Department of Biochemistry in 1986, and is currently Professor of Biochemical Parasitology and Head of the Department of Life Sciences. His research group works on nematode parasites, aiming primarily to understand how these pathogens effect long-term survival in mammalian hosts, with a particular focus on molecular mechanisms underlying regulation of the host immune system and resistance to immunity.

研究领域

Some of the most widespread infectious diseases of man are caused by helminth parasites, typically long-lived and persistent pathogens which are estimated to infect over one third of the world population, predominantly in developing countries. They are responsible for an enormous global burden of disease that does not receive sufficient funding for treatment, control and research. In common with protozoal parasites, no vaccines have yet been developed to counter helminth infection in people. In addition to their impact on human health, infection of livestock places a major burden on the world economy. There is a global trend towards development of resistance against the major classes of drugs used to control helminth infection, with sparse investment in discovery of new targets or development of new compounds. Recent years have seen rapid advances in our understanding of the mechanisms underlying immunity to helminths. At the same time, it has become apparent that parasites in turn utilise sophisticated mechanisms to suppress the host immune system. Our research programme is aimed at understanding how nematode (roundworm) parasites in particular effect long-term survival in mammalian hosts, with a particular focus on molecular mechanisms underlying regulation of the host immune system and resistance to immunity. We hope that these advances will lead to new drugs and vaccines to treat parasitic infection, in addition to new approaches to treat inflammation, allergy and autoimmunity.

近期论文

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Hunt VL, Tsai IJ, Selkirk ME, Viney Met al., 2016, The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism., Parasitology, Pages: 1-16 Schuijs MJ, Hartmann S, Selkirk ME, Roberts LB, Openshaw PJM, Schnoeller Cet al., 2016, The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10(+) T Cells, PLOS ONE, Vol: 11, ISSN: 1932-6203 Thawer S, Auret J, Schnoeller C, Chetty A, Smith K, Darby M, Roberts L, Mackay R-M, Whitwell HJ, Timms JF, Madsen J, Selkirk ME, Brombacher F, Clark HW, Horsnell WGCet al., 2016, Surfactant Protein-D Is Essential for Immunity to Helminth Infection, PLOS PATHOGENS, Vol: 12, ISSN: 1553-7366 Vaux R, Schnoeller C, Berkachy R, Roberts LB, Hagen J, Gounaris K, Selkirk MEet al., 2016, Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi., PLoS Pathog, Vol: 12 Darby M, Schnoeller C, Vira A, Culley F, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WGCet al., 2015, The M3 Muscarinic Receptor Is Required for Optimal Adaptive Immunity to Helminth and Bacterial Infection, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366 Sarkies P, Selkirk ME, Jones JT, Blok V, Boothby T, Goldstein B, Hanelt B, Ardila-Garcia A, Fast NM, Schiffer PM, Kraus C, Taylor MJ, Koutsovoulos G, Blaxter ML, Miska EAet al., 2015, Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages, PLOS BIOLOGY, Vol: 13, ISSN: 1545-7885 Rashidi NM, Scott MK, Scherf N, Krinner A, Kalchschmidt JS, Gounaris K, Selkirk ME, Roeder I, Lo Celso Cet al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, BLOOD, Vol: 124, Pages: 79-83, ISSN: 0006-4971 Afferson HC, Eleftheriou E, Selkirk ME, Gounaris Ket al., 2012, Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1, INFECTION AND IMMUNITY, Vol: 80, Pages: 3761-3767, ISSN: 0019-9567 Pezzementi L, Krejci E, Chatonnet A, Selkirk ME, Matthews JBet al., 2012, A tetrameric acetylcholinesterase from the parasitic nematode Dictyocaulus viviparus associates with the vertebrate tail proteins PRiMA and ColQ, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 181, Pages: 40-48, ISSN: 0166-6851 Selkirk ME, Huang SC, Knox DP, Britton Cet al., 2012, The development of RNA interference (RNAi) in gastrointestinal nematodes, PARASITOLOGY, Vol: 139, Pages: 605-612, ISSN: 0031-1820 White RR, Miyata S, Papa E, Spooner E, Gounaris K, Selkirk ME, Artavanis-Tsakonas Ket al., 2011, Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner, PLOS NEGLECTED TROPICAL DISEASES, Vol: 5, ISSN: 1935-2727 Huang SC-C, Chan DTY, Smyth DJ, Ball G, Gounaris K, Selkirk MEet al., 2010, Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 40, Pages: 1619-1628, ISSN: 0020-7519 Rees-Roberts D, Mullen LM, Gounaris K, Selkirk MEet al., 2010, Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 40, Pages: 527-532, ISSN: 0020-7519 Guiliano DB, Oksov Y, Lustigman S, Gounaris K, Selkirk MEet al., 2009, Characterisation of novel protein families secreted by muscle stage larvae of Trichinella spiralis, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 515-524, ISSN: 0020-7519 Ball G, Selkirk ME, Knox DP, 2007, The effect of vaccination with a recombinant Nippostrongylus brasiliensis acetylcholinesterase on infection outcome in the rat, VACCINE, Vol: 25, Pages: 3365-3372, ISSN: 0264-410X Bruce AF, Gares MP, Selkirk ME, Gounaris Ket al., 2006, Functional characterisation of a nematode secreted GM2-activator protein, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 147, Pages: 224-229, ISSN: 0166-6851 Furze RC, Culley FJ, Selkirk ME, 2006, Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis, MICROBES AND INFECTION, Vol: 8, Pages: 2803-2810, ISSN: 1286-4579 Furze RC, Hussell T, Selkirk ME, 2006, Amelioration of influenza-induced pathology in mice by coinfection with Trichinella spiralis, INFECTION AND IMMUNITY, Vol: 74, Pages: 1924-1932, ISSN: 0019-9567 Lazari O, Kipar A, Johnson DR, Selkirk ME, Matthews JBet al., 2006, Up-regulated expression of the alpha 7 nicotinic acetylcholine receptor subunit on inflammatory infiltrates during Dictyocaulus viviparus infection, PARASITE IMMUNOLOGY, Vol: 28, Pages: 429-437, ISSN: 0141-9838 Matthews JB, Lazari O, Davidson AJ, Warren S, Selkirk MEet al., 2006, A tryptophan amphiphilic tetramerization domain-containing acetylcholinesterase from the bovine lungworm, Dictyocaulus viviparus, PARASITOLOGY, Vol: 133, Pages: 381-387, ISSN: 0031-1820