Rutherford, Bill - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

My career aim is to understand the water oxidising enzyme Photosystem II in terms of its mechanism, its assembly and its evolutionary relationships with other photosynthetic reaction centres. This enzyme has become the focus of attention because cheap water splitting catalysts are urgently needed in the energy sector for solar fuel production, electrolysis of water and the reverse reaction in fuel cells. My research has made major contributions to understanding this enzyme before it was either popular or profitable. Now that it is finally becoming both of those, I hope to continue to do more of the same. Not just because it might contribute to solving aspects of the energy crisis but also because understanding the enzyme, which put the energy into the biosphere, the oxygen into the atmosphere and thence changed the planet, is one of the greatest challenges in biology and chemistry. It is also a fun enzyme to work on.

近期论文

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Brinkert K, De Causmaecker S, Krieger-Liszkay A, Fantuzzi A, Rutherford AWet al., 2016, Bicarbonate-induced redox tuning in Photosystem II for regulation and protection., Proc Natl Acad Sci U S A, Vol: 113, Pages: 12144-12149, ISSN: 0027-8424 Brinkert K, Le Formal F, Li X, Durrant J, Rutherford AW, Fantuzzi Aet al., 2016, Photocurrents from photosystem II in a metal oxide hybrid system: Electron transfer pathways, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1857, Pages: 1497-1505, ISSN: 0005-2728 Davis GA, Kanazawa A, Schöttler MA, Kohzuma K, Froehlich JE, Rutherford AW, Satoh-Cruz M, Minhas D, Tietz S, Dhingra A, Kramer DMet al., 2016, Limitations to photosynthesis by proton motive force-induced photosystem II photodamage., Elife, Vol: 5 MacKellar D, Lieber L, Norman JS, Bolger A, Tobin C, Murray JW, Oksaksin M, Chang RL, Ford TJ, Nguyen PQ, Woodward J, Permingeat HR, Joshi NS, Silver PA, Usadel B, Rutherford AW, Friesen ML, Prell Jet al., 2016, Streptomyces thermoautotrophicus does not fix nitrogen, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Ugur I, Rutherford AW, Kaila VRI, 2016, Redox-coupled substrate water reorganization in the active site of Photosystem II-The role of calcium in substrate water delivery, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1857, Pages: 740-748, ISSN: 0005-2728 Boussac A, Rutherford AW, Sugiura M, 2015, Electron transfer pathways from the S-2-states to the S-3-states either after a Ca2+/Sr2+ or a Cl-/I- exchange in Photosystem II from, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1847, Pages: 576-586, ISSN: 0005-2728 Cardona T, Murray JW, Rutherford AW, 2015, Origin and Evolution of Water Oxidation before the Last Common Ancestor of the Cyanobacteria, MOLECULAR BIOLOGY AND EVOLUTION, Vol: 32, Pages: 1310-1328, ISSN: 0737-4038 Cotton CA, Douglass JS, De Causmaecker S, Brinkert K, Cardona T, Fantuzzi A, Rutherford AW, Murray JWet al., 2015, Photosynthetic constraints on fuel from microbes., Front Bioeng Biotechnol, Vol: 3 Mersch D, Lee C-Y, Zhang JZ, Brinkert K, Fontecilla-Camps JC, Rutherford AW, Reisner Eet al., 2015, Wiring of Photosystem II to Hydrogenase for Photoelectrochemical Water Splitting, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 137, Pages: 8541-8549, ISSN: 0002-7863 Saito K, Rutherford AW, Ishikita H, 2015, Energetics of proton release on the first oxidation step in the water-oxidizing enzyme, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723 Sugiura M, Azami C, Koyama K, Rutherford AW, Rappaport F, Boussac Aet al., 2014, Modification of the pheophytin redox potential in Therrnosynechococcus elongatus Photosystem II with PsbA3 as D1, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1837, Pages: 139-148, ISSN: 0005-2728 Faunce T, Styring S, Wasielewski MR, Brudvig GW, Rutherford AW, Messinger J, Lee AF, Hill CL, deGroot H, Fontecave M, MacFarlane DR, Hankamer B, Nocera DG, Tiede DM, Dau H, Hillier W, Wang L, Amal Ret al., 2013, Artificial photosynthesis as a frontier technology for energy sustainability, ENERGY & ENVIRONMENTAL SCIENCE, Vol: 6, Pages: 1074-1076, ISSN: 1754-5692 Faunce TA, Lubitz W, Rutherford AWB, MacFarlane DR, Moore GF, Yang P, Nocera DG, Moore TA, Gregory DH, Fukuzumi S, Yoon KB, Armstrong FA, Wasielewski MR, Styring Set al., 2013, Energy and environment policy case for a global project on artificial photosynthesis, ENERGY & ENVIRONMENTAL SCIENCE, Vol: 6, Pages: 695-698, ISSN: 1754-5692 Kato M, Cardona T, Rutherford AW, Reisner Eet al., 2013, Covalent Immobilization of Oriented Photosystem II on a Nanostructured Electrode for Solar Water Oxidation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 135, Pages: 10610-10613, ISSN: 0002-7863 Saito K, Rutherford AW, Ishikita H, 2013, Mechanism of proton-coupled quinone reduction in Photosystem II, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 954-959, ISSN: 0027-8424 Saito K, Rutherford AW, Ishikita H, 2013, Mechanism of tyrosine D oxidation in Photosystem II, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 7690-7695, ISSN: 0027-8424 Thapper A, Styring S, Saracco G, Rutherford AW, Robert B, Magnuson A, Lubitz W, Llobet A, Kurz P, Holzwarth A, Fiechter S, De Groot H, Campagna S, Braun A, Bercegol H, Artero Vet al., 2013, Artificial photosynthesis for solar fuels - An evolving research field within AMPEA, a joint programme of the European energy research alliance, Green, Vol: 3, Pages: 43-57, ISSN: 1869-876X Zhao Z, Rutherford AW, Moser CC, Dutton PLet al., 2013, Photosynthetic Reaction Center Performance under Physiologically Relevant Energetic Changes, 57th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 489A-489A, ISSN: 0006-3495 Cardona T, Sedoud A, Cox N, Rutherford AWet al., 2012, Charge separation in Photosystem II: A comparative and evolutionary overview, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1817, Pages: 26-43, ISSN: 0005-2728 Dutton PL, Zhao Z, Rutherford AW, Moser CCet al., 2012, Electron tunneling in biological energetics, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1817, Pages: S3-S4, ISSN: 0005-2728