Rudenko, Gloria - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

My research group studies African trypanosomes, which cause African Sleeping Sickness in sub-Saharan Africa. African trypanosomes are single-celled organisms which multiply extracellularly in the bloodstream of the infected mammalian host. Trypanosomes are very adept at changing their Variant Surface Glycoprotein (VSG) surface coat, allowing them to continuously escape from antibody attack during the course of a chronic infection. This continuous switching of the VSG surface coat is referred to as antigenic variation. We are studying the molecular mechanisms mediating antigenic variation in African trypanosomes. We are interested in how this protective VSG coat is synthesised, and how VSG protein is monitored during the trypanosome cell cycle. In addition, we are interested in how the transcription of VSG is regulated. Individual trypanosomes have many hundreds of VSG genes, of which only one VSG variant is expressed at a time. We are currently investigating how this stringent transcriptional control is mediated. I am a Wellcome Senior Research Fellow/ Professor in Molecular Microbiology. I have an M.Sc in Biochemistry from the University of Leiden, the Netherlands and a Ph.D in Molecular Biology from the University of Amsterdam on the basis of research performed in the Department of Genetics, Columbia University, New York, NY. I did postdoctoral research on antigenic variation in African trypanosomes in the laboratory of Prof. Piet Borst at the Netherlands Cancer Institute, Amsterdam. I came to the UK as a Wellcome Senior Fellow in the Basic Biomedical Sciences at the University of Oxford, where I set up a research group in the Peter Medawar Building for Pathogen Research with an academic affiliation with the Department of Biochemistry.

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Stanne T, Narayanan MS, Ridewood S, Ling A, Witmer K, Kushwaha M, Wiesler S, Wickstead B, Wood J, Rudenko Get al., 2015, Identification of the ISWI chromatin remodeling complex of the early branching eukaryote Trypanosoma brucei, Journal of Biological Chemistry, Vol: 290, Pages: 26954-26967, ISSN: 0021-9258 Stanne TM, Narayanan MS, Ridewood S, Ling A, Witmer K, Kushwaha M, Wiesler S, Wickstead B, Wood J, Rudenko Get al., 2015, Identification of the ISWI chromatin remodeling complex of the early branching eukaryote Trypanosoma brucei., J Biol Chem, Vol: 290 Denninger V, Fullbrook A, Bessat M, Ersfeld K, Rudenko Get al., 2014, The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma brucei, MOLECULAR MICROBIOLOGY, Vol: 92, Pages: 901-901, ISSN: 0950-382X Denninger V, Rudenko G, 2014, FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei, MOLECULAR MICROBIOLOGY, Vol: 94, Pages: 945-962, ISSN: 0950-382X Ooi C-P, Rudenko G, 2014, Do trypanosome turncoats wait before they commit?, ELIFE, Vol: 3, ISSN: 2050-084X Narayanan MS, Rudenko G, 2013, TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes, NUCLEIC ACIDS RESEARCH, Vol: 41, Pages: 2981-2992, ISSN: 0305-1048 Povelones ML, Gluenz E, Dembek M, Gull K, Rudenko Get al., 2012, Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei, PLOS PATHOGENS, Vol: 8, ISSN: 1553-7374 Rudenko G, 2012, High-throughput whole genome analysis provides insight into how the major drugs against African sleeping sickness operate, PATHOGENS AND GLOBAL HEALTH, Vol: 106, Pages: 79-79, ISSN: 2047-7724 Vink C, Rudenko G, Seifert HS, 2012, Microbial antigenic variation mediated by homologous DNA recombination, FEMS MICROBIOLOGY REVIEWS, Vol: 36, Pages: 917-948, ISSN: 0168-6445 Narayanan MS, Kushwaha M, Ersfeld K, Fullbrook A, Stanne TM, Rudenko Get al., 2011, NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei, NUCLEIC ACIDS RESEARCH, Vol: 39, Pages: 2018-2031, ISSN: 0305-1048 Rudenko G, 2011, African trypanosomes: the genome and adaptations for immune evasion, ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY, Vol: 51, Pages: 47-62, ISSN: 0071-1365 Stanne TM, Kushwaha M, Wand M, Taylor JE, Rudenko Get al., 2011, TbISWI Regulates Multiple Polymerase I (Pol I)-Transcribed Loci and Is Present at Pol II Transcription Boundaries in Trypanosoma brucei, EUKARYOTIC CELL, Vol: 10, Pages: 964-976, ISSN: 1535-9778 Denninger V, Fullbrook A, Bessat M, Ersfeld K, Rudenko Get al., 2010, The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma brucei, MOLECULAR MICROBIOLOGY, Vol: 78, Pages: 459-474, ISSN: 0950-382X Rudenko G, 2010, Epigenetics and transcriptional control in African trypanosomes, ESSAYS IN BIOCHEMISTRY: EPIGENETICS, DISEASE AND BEHAVIOUR, Vol: 48, Pages: 201-219, ISSN: 0071-1365 Stanne TM, Rudenko G, 2010, Active VSG Expression Sites in Trypanosoma brucei Are Depleted of Nucleosomes, EUKARYOTIC CELL, Vol: 9, Pages: 136-147, ISSN: 1535-9778 Smith TK, Vasileva N, Gluenz E, Terry S, Portman N, Kramer S, Carrington M, Michaeli S, Gull K, Rudenko Get al., 2009, Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation, PLOS ONE, Vol: 4, ISSN: 1932-6203 Hertz-Fowler C, Figueiredo LM, Quail MA, Becker M, Jackson A, Bason N, Brooks K, Churcher C, Fahkro S, Goodhead I, Heath P, Kartvelishvili M, Mungall K, Harris D, Hauser H, Sanders M, Saunders D, Seeger K, Sharp S, Taylor JE, Walker D, White B, Young R, Cross GAM, Rudenko G, Barry JD, Louis EJ, Berriman Met al., 2008, Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei, PLOS ONE, Vol: 3, ISSN: 1932-6203 Young R, Taylor JE, Kurioka A, Becker M, Louis EJ, Rudenko Get al., 2008, Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum, BMC GENOMICS, Vol: 9, ISSN: 1471-2164 Hughes K, Wand M, Foulston L, Young R, Harley K, Terry S, Ersfeld K, Rudenko Get al., 2007, A novel ISWI is involved in VSG expression site downregulation in African trypanosomes, EMBO JOURNAL, Vol: 26, Pages: 2400-2410, ISSN: 0261-4189 Taylor JE, Rudenko G, 2006, Switching trypanosome coats: what's in the wardrobe?, TRENDS IN GENETICS, Vol: 22, Pages: 614-620, ISSN: 0168-9525