Okuse, Kenji - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

Research in our laboratory focuses on the molecular mechanism of pain pathways. We employ primary cultures of sensory neurons and macrophages, live cell imaging, and molecular biology. 1. Roles of neuropeptide VGF and its receptor in neuropathic pain. 2. Roles of macrophages in hyper-excitation of sensory neurons. 3. The mechanism of hypersensitisation of sensory neurons in chronic pain conditions.

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Rizaner N, Onkal R, Fraser SP, Pristera A, Okuse K, Djamgoz MBAet al., 2016, Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol: 45, Pages: 735-748, ISSN: 0175-7571 Moss PJ, Huang W, Dawes J, Okuse K, McMahon SB, Rice ASCet al., 2015, Macrophage-sensory neuronal interaction in HIV-1 gp120-induced neurotoxicity, BRITISH JOURNAL OF ANAESTHESIA, Vol: 114, Pages: 499-508, ISSN: 0007-0912 Chen Y-C, Pristera A, Ayub M, Swanwick RS, Karu K, Hamada Y, Rice ASC, Okuse Ket al., 2013, Identification of a Receptor for Neuropeptide VGF and Its Role in Neuropathic Pain, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 34638-34646, ISSN: 0021-9258 Huang W, Calvo M, Karu K, Olausen HR, Bathgate G, Okuse K, Bennett DLH, Rice ASCet al., 2013, A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy, PAIN, Vol: 154, Pages: 560-575, ISSN: 0304-3959 Okuse K, Ayub M, Swanwick R, Chen Yet al., 2013, New receptor identified for neuropathic pain Pristerà A, Baker MD, Okuse K, 2013, Correction: Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability., PLoS One, Vol: 8 Pristera A, Baker MD, Okuse K, 2012, Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability, PLOS ONE, Vol: 7, ISSN: 1932-6203 Pristera A, Okuse K, 2012, Building Excitable Membranes: Lipid Rafts and Multiple Controls on Trafficking of Electrogenic Molecules, NEUROSCIENTIST, Vol: 18, Pages: 70-81, ISSN: 1073-8584 Baker MD, Chen Y-C, Shah SU, Okuse Ket al., 2011, In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons, MOLECULAR AND CELLULAR NEUROSCIENCE, Vol: 48, Pages: 258-265, ISSN: 1044-7431 Okuse K, Finn A, Pristera A, 2011, Clustering of voltage-gated sodium channel Na(V)1.8 in lipid rafts is essential for action potential propagation in nociceptive unmyelinated axons, 8th EBSA European Biophysics Congress, Publisher: SPRINGER, Pages: 189-189, ISSN: 0175-7571 Ayub M, Chen Y-C, Nagy I, Rice AS, Okuse Ket al., 2010, EFFECTS OF VGF-DERIVED PEPTIDES ON PRIMARY SENSORY NEURONS AND MICROGLIA, 13th World Congress on Pain Moss PJ, Okuse K, Rice AS, 2010, HIV-1 GP120-MEDIATED EFFECTS ON NEURITE OUTGROWTH IN CULTURED PRIMARY SENSORY NEURONS, 13th World Congress on Pain Okuse K, 2010, Clustering of NaV1.8 in lipid rafts on nociceptive unmyelinated axons, 30th European Winter Conference on Brain Research Okuse K, Malik-Hall M, Poon W-YL, Baker MD, Wood JNet al., 2010, Sodium channels - Assays and modulators, novel clones, U.K. patent Filing number: 0211833.9 Swanwick RS, Pristera A, Okuse K, 2010, The trafficking of Na(V)1.8, NEUROSCIENCE LETTERS, Vol: 486, Pages: 78-83, ISSN: 0304-3940 Tsang SW, Shao D, Cheah KSE, Okuse K, Leung PS, Yao K-Met al., 2010, Increased basal insulin secretion in Pdzd2-deficient mice, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 315, Pages: 263-270, ISSN: 0303-7207 Maratou K, Wallace VCJ, Hasnie FS, Okuse K, Hosseini R, Jina N, Blackbeard J, Pheby T, Orengo C, Dickenson AH, McMahon SB, Rice ASCet al., 2009, Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain, EUROPEAN JOURNAL OF PAIN, Vol: 13, Pages: 387-398, ISSN: 1090-3801 Okuse K, 2009, Action potential propagation in unmyelinated axons of rat sensory neurons requires clustering of Nav1.8 channels in the lipid rafts, FASEB summer research conference Pristera A, Okuse K, 2009, Action potential propagation in unmyelinated axons of rat sensory neurons requires association of Nav1.8 channels with the lipid rafts, Society for Neuroscience Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon W-YL, Cheah KSE, Yao K-M, Wood JN, Okuse Ket al., 2009, A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8, MOLECULAR AND CELLULAR NEUROSCIENCE, Vol: 42, Pages: 219-225, ISSN: 1044-7431