Murray, James - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

Photosystem II (PSII) is the membrane protein-pigment complex which uses visible light photons to drive the oxidation of water (H2O), to oxgyen (O2), protons and electrons. After other reactions, the electrons are used to drive the reduction of carbon dioxide to organic molecules. Photosystem II generates almost all of the oxygen in the atmosphere, and is ultimately responsible for the fixation of most of the biomass, and fossil fuels on the Earth. Without PSII, the Earth would be much less hospitable to life. Apart from its intrinsic biological interest, replicating artifically the reaction of Photosystem II is vital for developing "artificial photosynthesis", the use of sunlight to generate fuels. We are studying ways to mimic the catalytic activity of photosystem II by engineering other proteins to bind a cluster of metal atoms in a similar way to the natural system. We are also working on the structures of proteins related to the assembly and repair of the PSII reaction centre.

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Burgess SJ, Taha H, Yeoman JA, Iamshanova O, Chan KX, Boehm M, Behrends V, Bundy JG, Bialek W, Murray JW, Nixon PJet al., 2016, Identification of the Elusive Pyruvate Reductase of Chlamydomonas reinhardtii Chloroplasts, PLANT AND CELL PHYSIOLOGY, Vol: 57, ISSN: 0032-0781 MacDonald JT, Kabasakal BV, Godding D, Kraatz S, Henderson L, Barber J, Freemont PS, Murray JWet al., 2016, Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 10346-10351, ISSN: 0027-8424 MacKellar D, Lieber L, Norman JS, Bolger A, Tobin C, Murray JW, Oksaksin M, Chang RL, Ford TJ, Nguyen PQ, Woodward J, Permingeat HR, Joshi NS, Silver PA, Usadel B, Rutherford AW, Friesen ML, Prell Jet al., 2016, Streptomyces thermoautotrophicus does not fix nitrogen, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Cardona T, Murray JW, Rutherford AW, 2015, Origin and Evolution of Water Oxidation before the Last Common Ancestor of the Cyanobacteria, MOLECULAR BIOLOGY AND EVOLUTION, Vol: 32, Pages: 1310-1328, ISSN: 0737-4038 Cotton CA, Douglass JS, De Causmaecker S, Brinkert K, Cardona T, Fantuzzi A, Rutherford AW, Murray JWet al., 2015, Photosynthetic constraints on fuel from microbes., Front Bioeng Biotechnol, Vol: 3 Cotton CAR, Kabasakal BV, Miah NA, Murray JWet al., 2015, Structure of the dual-function fructose-1,6/sedoheptulose-1,7-bisphosphatase from Thermosynechococcus elongatus bound with sedoheptulose-7-phosphate, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 71, Pages: 1341-1345, ISSN: 2053-230X Hingorani K, Pace R, Whitney S, Murray JW, Smith P, Cheah MH, Wydrzynski T, Hillier Wet al., 2014, Photo-oxidation of tyrosine in a bio-engineered bacterioferritin 'reaction centre'-A protein model for artificial photosynthesis, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1837, Pages: 1821-1834, ISSN: 0005-2728 Michoux F, Boehm M, Bialek W, Takasaka K, Maghlaoui K, Barber J, Murray JW, Nixon PJet al., 2014, Crystal structure of CyanoQ from the thermophilic cyanobacterium Thermosynechococcus elongatus and detection in isolated photosystem II complexes, PHOTOSYNTHESIS RESEARCH, Vol: 122, Pages: 57-67, ISSN: 0166-8595 Murray JW, 2014, Protein design for artificial photosynthesis, 247th National Spring Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727 Bialek W, Wen S, Michoux F, Beckova M, Komenda J, Murray JW, Nixon PJet al., 2013, Crystal structure of the Psb28 accessory factor of Thermosynechococcus elongatus photosystem II at 2.3 angstrom, PHOTOSYNTHESIS RESEARCH, Vol: 117, Pages: 375-383, ISSN: 0166-8595 Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Ayinampudi V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock ANet al., 2013, Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases (vol 288, pg 7803, 2013), JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 28304-28304, ISSN: 0021-9258 Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock ANet al., 2013, Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 7803-7814, ISSN: 0021-9258 Moore BL, Kelley LA, Barber J, Murray JW, MacDonald JTet al., 2013, High-quality protein backbone reconstruction from alpha carbons using gaussian mixture models, JOURNAL OF COMPUTATIONAL CHEMISTRY, Vol: 34, Pages: 1881-1889, ISSN: 0192-8651 Murray JW, 2013, Light and Life Photosynthesis, Biochemist, Vol: 35, Pages: 4-7, ISSN: 0954-982X Simon AC, Simpson PJ, Goldstone RM, Krysztofinska EM, Murray JW, High S, Isaacson RLet al., 2013, Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 1327-1332, ISSN: 0027-8424 Michoux F, Takasaka K, Boehm M, Komenda J, Nixon PJ, Murray JWet al., 2012, Crystal structure of the Psb27 assembly factor at 1.6: implications for binding to Photosystem II, PHOTOSYNTHESIS RESEARCH, Vol: 110, Pages: 169-175, ISSN: 0166-8595 Murray J, 2012, Redox active protein maquettes: Multi-functional"green enzymes", RSC Energy and Environment Series, Vol: 2012, Pages: 408-425, ISSN: 2044-0774 Murray JW, 2012, Sequence variation at the oxygen-evolving centre of photosystem II: a new class of 'rogue' cyanobacterial D1 proteins, PHOTOSYNTHESIS RESEARCH, Vol: 110, Pages: 177-184, ISSN: 0166-8595 Murray JW, 2011, Molecular Solar Fuels, Molecular Solar Fuels, Editors: Wydrzynski, Hillier, Peter, Publisher: RSC, Pages: 408-425, ISBN: 9781849730341 Michoux F, Takasaka K, Boehm M, Nixon PJ, Murray JWet al., 2010, Structure of CyanoP at 2.8 angstrom: Implications for the Evolution and Function of the PsbP Subunit of Photosystem II, BIOCHEMISTRY, Vol: 49, Pages: 7411-7413, ISSN: 0006-2960