Matthews, Steve - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

Our research vision focuses on unravelling the structural mechanisms by which pathogenic species attack their eukaryotic hosts. Diseases caused by bacteria, viruses, fungi and protozoa represent major challenges to humanity and its activities, impacting on quality of life, economic performance and food/water security. The long coexistence between microorganisms and higher eukaryotes has fine tuned their relationships. Cells sense and respond to their environment through molecular interactions that are often controlled by secreted proteins and complexes. These interactions are extremely complex and dynamic, but they are fundamental to disease progression, asymptomatic carriage and eventual elimination. It therefore comes as no surprise that these organisms have developed remarkable armouries of molecular systems for the trafficking of molecules across the outer-membrane and exchanging signals with their host. These processes are initiated by the specific recognition of host components by elaborate surface receptors, while secreted molecules enable the manipulation of cellular pathways from either outside or inside host cells. The molecular details of the transport, assembly and interactions of these pathogenic factors and the subsequent unravelling of disease processes are only just emerging. The follow research questions will be addressed:

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Hawthorne W, Rouse S, Sewell L, Matthews SJet al., Structural insights into functional amyloid inhibition in Gram –ve bacteria, Biochemical Society Transactions, ISSN: 1470-8752 Taylor JD, Matthews SJ, New insight into the molecular control of bacterial functional amyloids., Frontiers in Cellular and Infection Microbiology, Vol: 5, ISSN: 2235-2988 Berry J-L, Xu Y, Ward PN, Lea SM, Matthews SJ, Pelicic Vet al., 2016, A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding, STRUCTURE, Vol: 24, Pages: 926-934, ISSN: 0969-2126 Brown DR, Sheppard CM, Burchell L, Matthews S, Wigneshweraraj Set al., 2016, The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism., J Mol Biol, Vol: 428, Pages: 3911-3919 Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KWet al., 2016, PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2), NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723 Lee WC, Matthews S, Garnett JA, 2016, Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein., Protein Sci, Vol: 25, Pages: 1898-1905 Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry Set al., 2016, A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation., PLOS Pathogens, Vol: 12, ISSN: 1553-7366 Liang X, Liu B, Zhu F, Scannapieco FA, Haase EM, Matthews S, Wu Het al., 2016, A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property, Scientific Reports, Vol: 6, ISSN: 2045-2322 Miliara X, Matthews S, 2016, Structural comparison of yeast and human intra-mitochondrial lipid transport systems, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 44, Pages: 479-485, ISSN: 0300-5127 Rasheed M, Garnett J, Perez-Dorado I, Muhl D, Filloux A, Matthews Set al., 2016, Crystal structure of the CupB6 adhesive tip from the chaperone-usher family of pili from Pseudomonas aeruginosa, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Vol: 1864, Pages: 1500-1505, ISSN: 1570-9639 Taglialegna A, Navarro S, Ventura S, Garnett JA, Matthews S, Penades JR, Lasa I, Valle Jet al., 2016, Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals, PLOS PATHOGENS, Vol: 12, ISSN: 1553-7366 Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TPJ, Matthews SJet al., 2016, Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Taylor JD, Taylor G, Hare SA, Matthews SJet al., 2016, Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 554-560, ISSN: 0022-2836 Benjamin S, Williams F, Kerry L, Matthews Set al., 2015, NMR assignment of the immune mapped protein 1 (IMP1) homologue from Plasmodium falciparum, BIOMOLECULAR NMR ASSIGNMENTS, Vol: 9, Pages: 393-395, ISSN: 1874-2718 Curry S, Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IGet al., 2015, A conserved interaction between a C-terminal motif in Norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation, Publisher: bioRxiv Evans ML, Chorell E, Taylor JD, Aden J, Gotheson A, Li F, Koch M, Sefer L, Matthews SJ, Wittung-Stafshede P, Almqvist F, Chapman MRet al., 2015, The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation, MOLECULAR CELL, Vol: 57, Pages: 445-455, ISSN: 1097-2765 Garnett JA, Diallo M, Matthews SJ, 2015, Purification, crystallization and preliminary X-ray diffraction analysis of the Escherichia coli common pilus chaperone EcpB, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Vol: 71, Pages: 676-679, ISSN: 2053-230X Garnett JA, Muhl D, Douse CH, Hui K, Busch A, Omisore A, Yang Y, Simpson P, Marchant J, Waksman G, Matthews S, Filloux Aet al., 2015, Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation, PROTEIN SCIENCE, Vol: 24, Pages: 670-687, ISSN: 0961-8368 Huynh M-H, Liu B, Henry M, Liew L, Matthews SJ, Carruthers VBet al., 2015, Structural Basis of Toxoplasma gondii MIC2-associated Protein Interaction with MIC2, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 1432-1441, ISSN: 0021-9258 Liu B, Zhu F, Wu H, Matthews Set al., 2015, NMR assignment of the amylase-binding protein A from Streptococcus parasanguinis, BIOMOLECULAR NMR ASSIGNMENTS, Vol: 9, Pages: 173-175, ISSN: 1874-2718