Celso, CristinaLo - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

Adult haematopoietic stem cells (HSC) maintain all peripheral blood and immune system lineages during steady-state and in response to injuries. Their function depends on a tight balance between quiescence, self-renewal and differentiation, regulated by both cell intrinsic and extrinsic mechanisms. About three decades ago it was postulated that the stem cell microenvironment (or niche) contributes to maintaining their quiescence and regulates their number. Leukaemia develops from defects in such balance and overtakes normal haematopoiesis.While the interaction between HSC and the bone marrow microenvironment, or niche, has been proven key for correct haematopoiesis, little is known about the interrelationship between normal HSC, leukaemia cells and the bone marrow microenvironment.

近期论文

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Khorshed RA, Lo Celso C, 2016, MACHINE LEARNING CLASSIFICATION OF COMPLEX VASCULATURE STRUCTURES FROM IN-VIVO BONE MARROW 3D DATA, IEEE 13th International Symposium on Biomedical Imaging (ISBI), Publisher: IEEE, Pages: 1217-1220, ISSN: 1945-7928 Khorshed RA, Lo Celso C, 2016, Automated identification and measurement of Hematopoietic Stem Cells in 3D Intravital Microscopy Data, Microscopy and Analysis, Editors: Stanciu, Publisher: InTech, ISBN: 978-953-51-2578-5 MacLean AL, Lo Celso C, Stumpf MP, 2016, Concise Review: Stem Cell Population Biology: Insights from Hematopoiesis., Stem Cells Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DTet al., 2016, Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators., Cell Stem Cell, Vol: 19, Pages: 530-543 Vainieri ML, Blagborough AM, MacLean AL, Haltalli ML, Ruivo N, Fletcher HA, Stumpf MP, Sinden RE, Celso CLet al., 2016, Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points., Open Biol, Vol: 6 Khorshed RA, Hawkins ED, Duarte D, Scott MK, Akinduro OA, Rashidi NM, Spitaler M, Lo Celso Cet al., 2015, Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data, STEM CELL REPORTS, Vol: 5, Pages: 139-153, ISSN: 2213-6711 Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O, Lo Celso C, Hagemann T, Hodivala-Dilke Ket al., 2014, Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis., Nat Commun, Vol: 5 Rashidi NM, Scott MK, Scherf N, Krinner A, Kalchschmidt JS, Gounaris K, Selkirk ME, Roeder I, Lo Celso Cet al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, BLOOD, Vol: 124, Pages: 79-83, ISSN: 0006-4971 Scott MK, Akinduro O, Lo Celso C, 2014, In vivo 4-dimensional tracking of hematopoietic stem and progenitor cells in adult mouse calvarial bone marrow., J Vis Exp Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Spencer JA, Celso CL, Scadden DT, Strom TB, Lin CPet al., 2013, Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label., PLoS One, Vol: 8 Fink J, Kent D, Li J, Hawkins E, Lo Celso C, Green Aet al., 2013, HOMOZYGOUS JAK2V617F DRIVES RAPID HEMATOPOIETIC STEM CELL PROLIFERATION AND DIFFERENTIATION AT THE EXPENSE OF SELF-RENEWAL, 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S15-S15, ISSN: 0301-472X Hawkins ED, Lo Celso C, 2013, Subdivision of bone marrow microenvironments: purpose built homes for haematopoietic stem cells, EMBO JOURNAL, Vol: 32, Pages: 176-177, ISSN: 0261-4189 Joseph C, Quach JM, Walkley CR, Lane SW, Lo Celso C, Purton LEet al., 2013, Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies., Cell Stem Cell, Vol: 13, Pages: 520-533 Lo Celso C, 2013, IN VIVO IMAGING OF QUIESCENT AND PHYSIOLOGICALLY ACTIVATED HAEMATOPOIETIC STEM CELLS, 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S4-S4, ISSN: 0301-472X MacLean AL, Lo Celso C, Stumpf MPH, 2013, Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 10, ISSN: 1742-5689 Progatzky F, Dallman MJ, Lo Celso C, 2013, From seeing to believing: labelling strategies for in vivo cell-tracking experiments, INTERFACE FOCUS, Vol: 3, ISSN: 2042-8898 Roeder I, Krinner A, Scherf N, Scott M, Rashidi N, Pompe T, Lo Celso Cet al., 2013, QUANTIFICATION OF STEM CELL/NICHE INTERACTIONS BY COUPLING IN VIVO IMAGING AND IN SILICO SIMULATION, 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S31-S31, ISSN: 0301-472X Barrett O, Sottocornola R, Lo Celso C, 2012, In vivo imaging of hematopoietic stem cells in the bone marrow niche., Methods Mol Biol, Vol: 916, Pages: 231-242 Sottocornola R, Lo Celso C, 2012, Dormancy in the stem cell niche, STEM CELL RESEARCH & THERAPY, Vol: 3, ISSN: 1757-6512 Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher Tet al., 2011, Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification., Blood, Vol: 118, Pages: 1264-1273