Iwata, So - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

Prof. Iwata was awarded a Ph.D. at University of Tokyo in 1991. After postdoctoral research experience at Photon Factory, Japan (1991-2) and at the Max-Planck-Institute for Biophysics, Germany (1992-6), he became a lecturer at Uppsala University, Sweden in 1996. He joined Imperial College London in 2000 as the Chair of Membrane Protein Crystallography and became Director of Centre for Structural Biology in January 2005. He also holds positions as a Diamond Fellow at Diamond Light Source and the Research Director of ERATO IWATA Human Receptor Crystallography project. In December 2005, he was given the title of David Blow Chair of Biophysics. He has solved various membrane protein structures, which are essential for the cell functions, including cytochrome c oxidase, lactose permease and photosystem II. His current main interest is to establish the structural determination method of human membrane proteins including G-protein coupled receptors, which are major drug targets.

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Choudhury HG, Tong Z, Mathavan I, Li Y, Iwata S, Zirah S, Rebuffat S, van Veen HW, Beis Ket al., 2014, Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 9145-9150, ISSN: 0027-8424 Gallat F-X, Matsugaki N, Coussens NP, Yagi KJ, Boudes M, Higashi T, Tsuji D, Tatano Y, Suzuki M, Mizohata E, Tono K, Joti Y, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Nango E, Itoh K, Coulibaly F, Tobe S, Ramaswamy S, Stay B, Iwata S, Chavas LMGet al., 2014, In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436 Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MSP, Iwata S, Fishwick CWG, Johnson AP, Cameron AD, Henderson PJFet al., 2014, Molecular mechanism of ligand recognition by membrane transport protein, Mhp1, EMBO JOURNAL, Vol: 33, Pages: 1831-1844, ISSN: 0261-4189 Song C, Tono K, Park J, Ebisu T, Kim S, Shimada H, Kim S, Gallagher-Jones M, Nam D, Sato T, Togashi T, Ogawa K, Joti Y, Kameshima T, Ono S, Hatsui T, Iwata S, Yabashi M, Ishikawa Tet al., 2014, Multiple application X-ray imaging chamber for single-shot diffraction experiments with femtosecond X-ray laser pulses, JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol: 47, Pages: 188-197, ISSN: 0021-8898 Alam MJ, Arai S, Saijo S, Suzuki K, Mizutani K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Kakinuma Y, Yamato I, Murata Tet al., 2013, Loose Binding of the DF Axis with the A(3)B(3) Complex Stimulates the Initial Activity of Enterococcus hirae V-1-ATPase, PLOS ONE, Vol: 8, ISSN: 1932-6203 Alam MJ, Yamato I, Arai S, Saijo S, Mizutani K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Kakinuma Y, Murata Tet al., 2013, Mutant LV476-7 AA of A-subunit of Enterococcus hirae V-1-ATPase: High affinity of A(3)B(3) complex to DF axis and low ATPase activity, SPRINGERPLUS, Vol: 2, ISSN: 2193-1801 Arai S, Saijo S, Suzuki K, Mizutani K, Kakinuma Y, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Yamato I, Murata Tet al., 2013, Rotation mechanism of Enterococcus hirae V-1-ATPase based on asymmetric crystal structures, NATURE, Vol: 493, Pages: 703-+, ISSN: 0028-0836 Beckstein O, Drew D, Lee C, Yashiro S, Sansom MSP, Iwata S, Cameron ADet al., 2013, A Sodium-Sensitive Salt Bridge in the Na+/H+ Antiporter NhaA, 57th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 200A-200A, ISSN: 0006-3495 Foadi J, Aller P, Alguel Y, Cameron A, Axford D, Owen RL, Armour W, Waterman DG, Iwata S, Evans Get al., 2013, Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Vol: 69, Pages: 1617-1632, ISSN: 0907-4449 Hino T, Iwata S, Murata T, 2013, Generation of functional antibodies for mammalian membrane protein crystallography, CURRENT OPINION IN STRUCTURAL BIOLOGY, Vol: 23, Pages: 563-568, ISSN: 0959-440X Lee C, Kang HJ, von Ballmoos C, Newstead S, Uzdavinys P, Dotson DL, Iwata S, Beckstein O, Cameron AD, Drew Det al., 2013, A two-domain elevator mechanism for sodium/proton antiport, NATURE, Vol: 501, Pages: 573-+, ISSN: 0028-0836 Manolaridis I, Kulkarni K, Dodd RB, Ogasawara S, Zhang Z, Bineva G, O'Reilly N, Hanrahan SJ, Thompson AJ, Cronin N, Iwata S, Barford Det al., 2013, Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1, NATURE, Vol: 504, Pages: 301-+, ISSN: 0028-0836 Rahman S, Yamato I, Saijo S, Mizutani K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Iwata S, Murata Tet al., 2013, Biochemical and Biophysical Properties of Interactions between Subunits of the Peripheral Stalk Region of Human V-ATPase, PLOS ONE, Vol: 8, ISSN: 1932-6203 Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata Tet al., 2012, G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody, NATURE, Vol: 482, Pages: 237-U130, ISSN: 0028-0836 Iwata M, Lee Y, Yamashita T, Yagi T, Iwata S, Cameron AD, Maher MJet al., 2012, The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 15247-15252, ISSN: 0027-8424 Sasaki H, Kubota K, Lee WC, Ohtsuka J, Kojima M, Iwata S, Nakagawa A, Takahashi K, Tanokura Met al., 2012, The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis, JOURNAL OF BIOCHEMISTRY, Vol: 152, Pages: 45-52, ISSN: 0021-924X Shiroishi M, Tsujimoto H, Makyio H, Asada H, Yurugi-Kobayashi T, Shimamura T, Murata T, Nomura N, Haga T, Iwata S, Kobayashi Tet al., 2012, Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae, MICROBIAL CELL FACTORIES, Vol: 11, ISSN: 1475-2859 Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S, Newstead Set al., 2012, Alternating access mechanism in the POT family of oligopeptide transporters, EMBO JOURNAL, Vol: 31, Pages: 3411-3421, ISSN: 0261-4189 Asada H, Uemura T, Yurugi-Kobayashi T, Shiroishi M, Shimamura T, Tsujimoto H, Ito K, Sugawara T, Nakane T, Nomura N, Murata T, Haga T, Iwata S, Kobayashi Tet al., 2011, Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis, MICROBIAL CELL FACTORIES, Vol: 10, ISSN: 1475-2859 Bill RM, Henderson PJF, Iwata S, Kunji ERS, Michel H, Neutze R, Newstead S, Poolman B, Tate CG, Vogel Het al., 2011, Overcoming barriers to membrane protein structure determination, NATURE BIOTECHNOLOGY, Vol: 29, Pages: 335-340, ISSN: 1087-0156