Haslam, Stuart - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

After obtaining my first degree and PhD from the University of Leeds, my postdoctoral research at Imperial College London on nematode parasite glycosylation laid the foundations of high sensitivity mass spectrometric analysis of complex mixtures of oligosaccharides which are now widely exploited in glycomic analysis. In recognition of this work I was awarded a Young Scientist Award by the organizing and program committees of the XIVth International Symposium on Glycoconjugates, Zurich, Switzerland. This was one of seven awarded at this biennial conference and the only one to a British scientist. My more recent research has encompassed the structural analysis of glycoconjugates from diverse biological origins ranging from bacteria to humans including the analysis of several cancer derived cell lines. I was appointed to a lectureship in 2002 at Imperial College London and that year I was invited by the International Steering Committee of the Consortium for Functional Glycomics (CFG) to serve as Director of its Analytical Glycotechnology Core when this facility was re-located from San Diego to Imperial College as recommended by the CFG’s International Advisory Board. The CFG is an NIH-funded large research initiative aiming to understand the role of carbohydrate-protein interactions in cell-cell communication. Seven scientific cores provide resources to the international scientific community. The Analytical Glycotechnology Core, which is the only core to be based outside the USA, is involved in glycomic profiling of mouse and human tissues and performing carbohydrate structure analysis on carbohydrate binding protein ligands and specific mouse and human cell lines. I am also a member of the Steering Committee of the EuroCarbDB consortium which is funded by the European Commission 6th Framework Programme. This consortium aims to develop and distribute web-based carbohydrate data bases and I lead the Imperial College component which is responsible for MS activities.

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Haslam SM, Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding, Scientific Reports, Vol: 6, ISSN: 2045-2322 Aoki-Kinoshita K, Agravat S, Aoki NP, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam SM, Kawasaki T, Matsubara M, Moreman KW, Okuda S, Pierce M, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia J, Narimatsu Het al., 2016, GlyTouCan 1.0-The international glycan structure repository, NUCLEIC ACIDS RESEARCH, Vol: 44, Pages: D1237-D1242, ISSN: 0305-1048 Chen Q, Pang P-C, Cohen ME, Longtine MS, Schust DJ, Haslam SM, Blois SM, Dell A, Clark GFet al., 2016, Evidence for Differential Glycosylation of Trophoblast Cell Types, MOLECULAR & CELLULAR PROTEOMICS, Vol: 15, Pages: 1857-1866, ISSN: 1535-9476 Giovannone N, Sweeney JG, Liang J, Antonopoulos A, Pochebit SM, Bhattacharyya N, Barthel SR, Haslam SM, Dimitroff CJet al., 2016, The alpha 2,3 sialyltransferase ST3Gall regulates galectin-3 binding to human B cells, JOURNAL OF IMMUNOLOGY, Vol: 196, ISSN: 0022-1767 Kudelka MR, Antonopoulos A, Wang Y, Duong DM, Song X, Seyfried NT, Dell A, Haslam SM, Cummings RD, Ju Tet al., 2016, Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells, NATURE METHODS, Vol: 13, Pages: 81-+, ISSN: 1548-7091 Lete C, Markine-Goriaynoff N, Machiels B, Pang P-C, Xiao X, Canis K, Suzuki M, Fukuda M, Dell A, Haslam SM, Vanderplasschen A, Gillet Let al., 2016, Bovine Herpesvirus 4 Modulates Its beta-1,6-N-Acetylglucosaminyltransferase Activity through Alternative Splicing, JOURNAL OF VIROLOGY, Vol: 90, Pages: 2039-2051, ISSN: 0022-538X Mkhikian H, Mortales C-L, Zhou RW, Khachikyan K, Wu G, Haslam SM, Kavarian P, Dell A, Demetriou Met al., 2016, Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis, ELIFE, Vol: 5, ISSN: 2050-084X Mondal N, Stolfa G, Antonopoulos A, Zhu Y, Wang S-S, Buffone A, Atilla-Gokcumen GE, Haslam SM, Dell A, Neelamegham Set al., 2016, Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin-Dependent Rolling in the Multistep Leukocyte Adhesion Cascade, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 36, Pages: 718-727, ISSN: 1079-5642 Nita-Lazar M, Mancini J, Feng C, Gonzalez-Montalban N, Ravindran C, Jackson S, de las Heras-Sanchez A, Giomarelli B, Ahmed H, Haslam SM, Wu G, Dell A, Ammayappan A, Vakharia VN, Vasta GRet al., 2016, The zebrafish galectins Drgal1-L2 and Drgal3-L1 bind in vitro to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and reduce viral adhesion to fish epithelial cells, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Vol: 55, Pages: 241-252, ISSN: 0145-305X Pang P-C, Haslam SM, Dell A, Clark GFet al., 2016, The human fetoembryonic defense system hypothesis: Twenty years on, MOLECULAR ASPECTS OF MEDICINE, Vol: 51, Pages: 71-88, ISSN: 0098-2997 Panico M, Bouche L, Binet D, O'Connor M-J, Rahman D, Pang P-C, Canis K, North SJ, Desrosiers RC, Chertova E, Keele BF, Bess JW, Lifson JD, Haslam SM, Dell A, Morris HRet al., 2016, Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner Cet al., 2016, The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets., Glycobiology, Vol: 26, Pages: 907-910, ISSN: 0959-6658 Sweeney JG, Liang J, Giovannone N, Schaffer L, Head SR, Antonopoulos A, Haslam SM, Widlund HR, Dimitroff CJet al., 2016, "I"-branched Carbohydrates Negatively Regulate Galectin-3-binding and Melanoma Malignancy, JOURNAL OF IMMUNOLOGY, Vol: 196, ISSN: 0022-1767 Verissimo CM, Morassutti AL, von Itzstein M, Sutov G, Hartley-Tassell L, McAtamney S, Dell A, Haslam SM, Graeff-Teixeira Cet al., 2016, Characterization of the N-glycans of female Angiostrongylus cantonensis worms, EXPERIMENTAL PARASITOLOGY, Vol: 166, Pages: 137-143, ISSN: 0014-4894 Wu G, Hitchen PG, Panico M, North SJ, Barbouche M-R, Binet D, Morris HR, Dell A, Haslam SMet al., 2016, Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation, GLYCOCONJUGATE JOURNAL, Vol: 33, Pages: 447-456, ISSN: 0282-0080 Zhang H, Zhou M, Yang T, Haslam SM, Dell A, Wu Het al., 2016, New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein., J Biol Chem, Vol: 291, Pages: 22106-22117 Aoki NP, Aoki-Kinoshita K, Agravat S, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam S, Kawasaki T, Matsubara M, Moreman KW, Narimatsu H, Okuda S, Pierce JM, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia Jet al., 2015, The Official Release of the International Glycan Structure Repository, Annual Meeting of the Society-for-Glycobiology on Glycobiology - Accelerating Impact across the Biomedical Sciences, Publisher: OXFORD UNIV PRESS INC, Pages: 1279-1280, ISSN: 0959-6658 Chen Q, Müller JS, Pang PC, Laval SH, Haslam SM, Lochmüller H, Dell Aet al., 2015, Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)., Biomolecules, Vol: 5, Pages: 2758-2781 Czajkowsky DM, Andersen JT, Fuchs A, Wilson TJ, Mekhaiel D, Colonna M, He J, Shao Z, Mitchell DA, Wu G, Dell A, Haslam S, Lloyd KA, Moore SC, Sandlie I, Blundell PA, Pleass RJet al., 2015, Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322 Damerell D, Ceroni A, Maass K, Ranzinger R, Dell A, Haslam SMet al., 2015, Annotation of glycomics MS and MS/MS spectra using the GlycoWorkbench software tool., Methods Mol Biol, Vol: 1273, Pages: 3-15