Hartley, David - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

I am a lecturer and researcher in the Division of Cell & Molecular Biology. I've been here since 1990 and previously worked for five years at Yale University as a Research Fellow. My Research Interests concern the molecular mechanisms which determine cell behaviours during the development of the Central Nervous System. Currently, we are investigating the molecular anatomy of transcriptional repression complexes which regulate cell fate choices during development. Also, I'm interested in the role axonal guidance cues play in regulating neuronal survival. We make use of the model organism Drosophila in our studies due to the ease with which it can be genetically manipulated. I have a strong commitment to teaching and have been involved with maintaining course standards both within College and nationally. From 1998 - 2000 I was a Quality Assurance Agency Subject Specialist Reviewer and from 1999 - 2004 Director of Undergraduate Studies for Biochemistry. Currently I look after a number of courses within the Biochemistry degree programme, including fourth year MSci students.

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Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AMet al., 2000, dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, Vol: 44, Pages: 749-756, ISSN: 0214-6282 Hartley D, 1996, Drosophila inherit diseases, NATURE GENETICS, Vol: 13, Pages: 133-134, ISSN: 1061-4036 TATA F, HARTLEY DA, 1995, INHIBITION OF CELL FATE IN DROSOPHILA BY ENHANCER OF SPLIT GENES, MECHANISMS OF DEVELOPMENT, Vol: 51, Pages: 305-315, ISSN: 0925-4773 BROWN NH, HARTLEY DA, 1994, DROSOPHILA DEVELOPMENT - EXPLORING SIGNALING PATHWAYS, NATURE, Vol: 370, Pages: 414-415, ISSN: 0028-0836 TATA F, HARTLEY DA, 1993, THE ROLE OF THE ENHANCER OF SPLIT COMPLEX DURING CELL FATE DETERMINATION IN DROSOPHILA, DEVELOPMENT, Pages: 139-148, ISSN: 0950-1991 DELIDAKIS C, PREISS A, HARTLEY DA, ARTAVANISTSAKONAS Set al., 1991, 2 GENETICALLY AND MOLECULARLY DISTINCT FUNCTIONS INVOLVED IN EARLY NEUROGENESIS RESIDE WITHIN THE ENHANCER OF SPLIT LOCUS OF DROSOPHILA-MELANOGASTER, GENETICS, Vol: 129, Pages: 803-823, ISSN: 0016-6731 PREISS A, HARTLEY D, DELIDAKIS C, 1991, TOWARDS AN UNDERSTANDING OF E(SPL) NEUROGENIC FUNCTION, JOURNAL OF NEUROGENETICS, Vol: 7, Pages: 141-141, ISSN: 0167-7063 Artavanis-Tsakonas S, Delidakis C, Fehon R, Hartley D, Herndon V, Johansen K, Markopoulou K, Preiss A, Rebay I, Scottgale Net al., 1990, Notch and the molecular genetics of neuroblast segregation in Drosophila., Mol Reprod Dev, Vol: 27, Pages: 23-27, ISSN: 1040-452X HARTLEY D, WHITE R, 1990, DROSOPHILA IN CRETE - A FLYING VISIT, TRENDS IN GENETICS, Vol: 6, Pages: 199-201, ISSN: 0168-9525 Hartley DA, 1990, Early neurogenesis., Semin Cell Biol, Vol: 1, Pages: 185-196, ISSN: 1043-4682 Hartley DA, Preiss A, Artavanis-Tsakonas S, 1988, A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit., Cell, Vol: 55, Pages: 785-795, ISSN: 0092-8674 Preiss A, Hartley DA, Artavanis-Tsakonas S, 1988, The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila., EMBO J, Vol: 7, Pages: 3917-3927, ISSN: 0261-4189 Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas Set al., 1988, slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system., Cell, Vol: 55, Pages: 1047-1059, ISSN: 0092-8674 Hartley DA, Xu T, Artavanis-Tsakonas S, 1987, The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein, EMBO Journal, Vol: 7, Pages: 3917-3927 Hartley DA, Xu TA, Artavanis-Tsakonas S, 1987, The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein., EMBO J, Vol: 6, Pages: 3407-3417, ISSN: 0261-4189 NALBANTOGLU J, HARTLEY D, PHEAR G, TEAR G, MEUTH Met al., 1986, SPONTANEOUS DELETION FORMATION AT THE APRT LOCUS OF HAMSTER-CELLS - THE PRESENCE OF SHORT SEQUENCE HOMOLOGIES AND DYAD SYMMETRIES AT DELETION TERMINI, EMBO JOURNAL, Vol: 5, Pages: 1199-1204, ISSN: 0261-4189 Drayna D, Davies KE, Hartley D, Mandel JL, Camerino G, Williamson R, White Ret al., 1984, Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms, Proceedings of the National Academy of Sciences, Vol: 81, Pages: 2836-2839 Harper K, Winter RW, Pembrey ME, Hartley D, Davies KE, Tuddenham EGDet al., 1984, A clinically useful DNA probe closely linked to haemophilia, Lancet, Vol: ii, Pages: 6-8 Hartley DA, Davies KE, Drayna D, White RL, Williamson Ret al., 1984, A cytological map of the human X chromosome - evidence for non-random recombination, Nucleic Acids Research, Vol: 12, Pages: 5277-5285 Britton P, Boronat A, Hartley DA, Jones-Mortimer MC, Kornberg HL, Parra Fet al., 1983, Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: Location of the gsr (tgs) and iex (crr) genes by specialized transduction., Journal of General Microbiology, Vol: 129, Pages: 349-358