Hare, Stephen - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

MRC research fellow since September 2011, studying the structural biology of Neisserial pathogenesis and iron uptake. Pathogenic Neisseria species cause life threatening illness (N. meningitidis - meningitis and septicaemia) and sexually transmitted disease (N. gonorrhoea - gonorrhoea). For survival in their human host, Neisseria must aquire iron. However, almost all iron inside the host is complexed to proteins such as haemoglobin, leaving very little bioavailable iron in the blood and other bodily fluids for pathogens. To overcome this Neisseria sp. express outer membrane proteins (called TonB dependent transporters) that are able to extract iron directly from host proteins, including haemoglobin. We are currently studying the structural basis of haem iron extraction from haemoglobin by the HpuAB system.

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Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine Set al., 2016, A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA, MOLECULAR CELL, Vol: 63, Pages: 86-96, ISSN: 1097-2765 Grabe GJ, Zhang Y, Przydacz M, Rolhion N, Yang Y, Pruneda JN, Komander D, Holden DW, Hare SAet al., 2016, The Salmonella Effector SpvD is a Cysteine Hydrolase with a Serovar-Specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses and Bacterial Virulence., J Biol Chem Taylor JD, Taylor G, Hare SA, Matthews SJet al., 2016, Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 554-560, ISSN: 0022-2836 Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov Pet al., 2015, Structural basis for retroviral integration into nucleosomes, NATURE, Vol: 523, Pages: 366-+, ISSN: 0028-0836 Wong CT, Xu Y, Gupta A, Garnett JA, Matthews SJ, Hare SAet al., 2015, Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723 Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Oeztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov Pet al., 2014, Structural basis for nuclear import of splicing factors by human Transportin 3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 2728-2733, ISSN: 0027-8424 Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman Aet al., 2014, Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses., Mol Ther Methods Clin Dev, Vol: 1 Metifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR, Hughes SH, Cherepanov P, Pommier Yet al., 2013, Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 lntegrase, ACS CHEMICAL BIOLOGY, Vol: 8, Pages: 209-217, ISSN: 1554-8929 Hare S, Maertens GN, Cherepanov P, 2012, 3 '-Processing and strand transfer catalysed by retroviral integrase in crystallo, EMBO JOURNAL, Vol: 31, Pages: 3020-3028, ISSN: 0261-4189 Cherepanov P, Maertens GN, Hare S, 2011, Structural insights into the retroviral DNA integration apparatus, CURRENT OPINION IN STRUCTURAL BIOLOGY, Vol: 21, Pages: 249-256, ISSN: 0959-440X Hare S, Smith SJ, Metifiot M, Jaxa-Chamiec A, Pommier Y, Hughes SH, Cherepanov Pet al., 2011, Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572), MOLECULAR PHARMACOLOGY, Vol: 80, Pages: 565-572, ISSN: 0026-895X Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov Pet al., 2010, Retroviral intasome assembly and inhibition of DNA strand transfer, NATURE, Vol: 464, Pages: 232-U108, ISSN: 0028-0836 Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov Pet al., 2010, Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 20057-20062, ISSN: 0027-8424 Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman Aet al., 2010, Structure-based modeling of the functional HIV-1 intasome and its inhibition, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 15910-15915, ISSN: 0027-8424 Maertens GN, Hare S, Cherepanov P, 2010, The mechanism of retroviral integration from X-ray structures of its key intermediates, NATURE, Vol: 468, Pages: 326-U217, ISSN: 0028-0836 Hare S, Cherepanov P, 2009, The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights, VIRUSES-BASEL, Vol: 1, Pages: 780-801, ISSN: 1999-4915 Hare S, Cherepanov P, Wang J, 2009, Application of general formulas for the correction of a lattice-translocation defect in crystals of a lentiviral integrase in complex with LEDGF, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Vol: 65, Pages: 966-973, ISSN: 0907-4449 Hare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov Pet al., 2009, Structural Basis for Functional Tetramerization of Lentiviral Integrase, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366 Hare S, Shun M-C, Gupta SS, Valkov E, Engelman A, Cherepanov Pet al., 2009, A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75, PLOS PATHOGENS, Vol: 5, ISSN: 1553-7366 Valkov E, Gupta SS, Hare S, Helander A, Roversi P, McClure M, Cherepanov Pet al., 2009, Functional and structural characterization of the integrase from the prototype foamy virus, NUCLEIC ACIDS RESEARCH, Vol: 37, Pages: 243-255, ISSN: 0305-1048