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研究领域

My central research interest is in understanding how general anaesthetics act. I have worked on this problem mainly at the molecular and cellular levels but more recently I have become interested in how anaesthetics act at the level of neuronal networks and have been pursuing the possibility that the sedative and hypnotic actions of general anaesthetics may be mediated through the same neuronal pathways that control natural sleep. I work closely with Bill Wisden and Stephen Brickley.

近期论文

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Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards ADet al., 2016, Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial, LANCET NEUROLOGY, Vol: 15, Pages: 145-153, ISSN: 1474-4422 Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk Get al., 2016, Activation and modulation of recombinant glycine and GABA(A) receptors by 4-halogenated analogues of propofol, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 173, Pages: 3110-3120, ISSN: 0007-1188 Campos-Pires R, Armstrong SP, Sebastiani A, Luh C, Gruss M, Radyushkin K, Hirnet T, Werner C, Engelhard K, Franks NP, Thal SC, Dickinson Ret al., 2015, Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury, CRITICAL CARE MEDICINE, Vol: 43, Pages: 149-158, ISSN: 0090-3493 Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk Get al., 2015, Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human beta 3 Homomeric GABA(A) Receptors, MOLECULAR PHARMACOLOGY, Vol: 88, Pages: 736-745, ISSN: 0026-895X Franks NP, 2015, Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors., Anesthesiology, Vol: 122, Pages: 787-794 MacKenzie G, Franks NP, Brickley SG, 2015, Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 467, Pages: 989-999, ISSN: 0031-6768 Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden Wet al., 2015, The role of K-2P channels in anaesthesia and sleep, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Vol: 467, Pages: 907-916, ISSN: 0031-6768 Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden Wet al., 2015, Wakefulness Is Governed by GABA and Histamine Cotransmission, NEURON, Vol: 87, Pages: 164-178, ISSN: 0896-6273 Zhang Z, Ferretti V, Guentan I, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NPet al., 2015, Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha(2) adrenergic agonists, NATURE NEUROSCIENCE, Vol: 18, Pages: 553-+, ISSN: 1097-6256 Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NPet al., 2014, Altered Activity in the Central Medial Thalamus Precedes Changes in the Neocortex during Transitions into Both Sleep and Propofol Anesthesia, JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 13326-13335, ISSN: 0270-6474 Bertaccini EJ, Dickinson R, Trudell JR, Franks NPet al., 2014, Molecular Modeling of a Tandem Two Pore Domain Potassium Channel Reveals a Putative Binding Site for General Anesthetics, ACS CHEMICAL NEUROSCIENCE, Vol: 5, Pages: 1246-1252, ISSN: 1948-7193 Franks NP, 2014, The unfolding story of how general anesthetics act, The Wondrous Story of Anesthesia, Pages: 597-608, ISBN: 9781461484417 Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DWU, Vyssotski AL, van Lith HA, Wisden W, Franks NPet al., 2014, Staying awake - a genetic region that hinders alpha(2) adrenergic receptor agonist-induced sleep, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 40, Pages: 2311-2319, ISSN: 0953-816X Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden Wet al., 2014, Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture, CURRENT BIOLOGY, Vol: 24, Pages: 2838-2844, ISSN: 0960-9822 Harris K, Armstrong SP, Campos-Pires R, Kiru L, Franks NP, Dickinson Ret al., 2013, Neuroprotection against Traumatic Brain Injury by Xenon, but Not Argon, Is Mediated by Inhibition at the N-Methyl-D-Aspartate Receptor Glycine Site, ANESTHESIOLOGY, Vol: 119, Pages: 1137-1148, ISSN: 0003-3022 Yip GMS, Chen Z-W, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NPet al., 2013, A propofol binding site on mammalian GABA(A) receptors identified by photolabeling, NATURE CHEMICAL BIOLOGY, Vol: 9, Pages: 715-+, ISSN: 1552-4450 Armstrong SP, Banks PJ, McKitrick TJW, Geldart CH, Edge CJ, Babla R, Simillis C, Franks NP, Dickinson Ret al., 2012, Identification of Two Mutations (F758W and F758Y) in the N-methyl-D-aspartate Receptor Glycine-binding Site that Selectively Prevent Competitive Inhibition by Xenon without Affecting Glycine Binding, ANESTHESIOLOGY, Vol: 117, Pages: 38-47, ISSN: 0003-3022 Houston CM, McGee TP, MacKenzie G, Troyano-Cuturi K, Rodriguez PM, Kutsarova E, Diamanti E, Hosie AM, Franks NP, Brickley SGet al., 2012, Are Extrasynaptic GABA(A) Receptors Important Targets for Sedative/Hypnotic Drugs?, JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 3887-3897, ISSN: 0270-6474 Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DSet al., 2012, Xenon Neuroprotection in Experimental Stroke Interactions with Hypothermia and Intracerebral Hemorrhage, ANESTHESIOLOGY, Vol: 117, Pages: 1262-1275, ISSN: 0003-3022 Zecharia AY, Yu X, Goetz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden Wet al., 2012, GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep-Wake Switch or Propofol-Induced Loss of Consciousness, JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 13062-U368, ISSN: 0270-6474

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