Frankel, Gad - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

Successful control of bacterial infections is without a doubt one of the most important achievements of modern medicine. However, the rapid spread of antibiotic resistance, return of old pathogens and emergence of new opportunistic infections, in part due to the HIV pandemic, fuel an unrelenting need to develop new antimicrobial treatments and vaccines. These endpoints rely heavily on a better understanding of the mechanisms of virulence. journals In our laboratory we use a wide variety of biochemical, molecular and cellular biology approaches together with advanced imaging techniques to study the molecular pathogenesis of Gram-negative pathogens such as enterohaemorrhagic Escherichia coli (EHEC), that causes haemorrhagic colitis and haemolytic uraemic syndrome, enteropathogenic E. coli (EPEC), which causes paediatric diarrhoea, for which we pioneered the murine Citrobacter rodentium (aka mouse EPEC) model of EPEC and EHEC infection and Salmonella enterica serovars, including S. Typhi, which caused typhoid fever. More recently we launched a complementary project aimed at studying infection with Legionella pneumophila, an intracellular pathogen that causes an acute form of pneumonia known as Legionnaires’ disease. In recent decades promotion of healthier lifestyles has led to increased demand for fresh produce in many industrialized nations; their consumption is encouraged to protect against a range of illnesses such as cancers and cardiovascular diseases. Coincided with this trend is the emergence of fresh produce as a major vehicle for transmission of enteric pathogens that were traditionally classified as zoonotic. In our laboratory we study the association enteric human pathogens (particularly E. coli pathotypes and Salmonella enterica) with fresh produce, including salad leaves and tomatoes.

研究领域

Our group is supported by the BBSRC, MRC and the Wellcome Trust. In our laboratory we use a wide variety of biochemical, molecular and cellular biology approaches combined with advanced imaging techniques to study the molecular pathogenesis and dissemination of Gram-negative pathogens.

近期论文

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Crepin VF, Collins JW, Habibzay M, Frankel Get al., 2016, Citrobacter rodentium mouse model of bacterial infection., Nat Protoc, Vol: 11, Pages: 1851-1876 Furniss RCD, Slater S, Frankel G, Clements Aet al., 2016, Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 3399-3407, ISSN: 0022-2836 Pallett MA, Crepin VF, Serafini N, Habibzay M, Kotik O, Sanchez-Garrido J, Di Santo JP, Shenoy AR, Berger CN, Frankel Get al., 2016, Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells., Mucosal Immunol Pollard DJ, Young JC, Covarelli V, Herrera-León S, Connor TR, Fookes M, Walker D, Echeita A, Thomson NR, Berger CN, Frankel Get al., 2016, The type III secretion system effector SeoC of Salmonella enterica subspecies salamae and arizonae ADP-ribosylates Src and inhibits opsono-phagocytosis., Infect Immun So EC, Schroeder GN, Carson D, Mattheis C, Mousnier A, Broncel M, Tate EW, Frankel Get al., 2016, The Rab-binding Profiles of Bacterial Virulence Factors during Infection, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 291, Pages: 5832-5843, ISSN: 0021-9258 Crepin VF, Habibzay M, Glegola-Madejska I, Guenot M, Collins JW, Frankel Get al., 2015, Tir Triggers Expression of CXCL1 in Enterocytes and Neutrophil Recruitment during Citrobacter rodentium Infection, INFECTION AND IMMUNITY, Vol: 83, Pages: 3342-3354, ISSN: 0019-9567 Hunter PJ, Shaw RK, Berger CN, Frankel G, Pink D, Hand Pet al., 2015, Older leaves of lettuce (Lactuca spp.) support higher levels of Salmonella enterica ser. Senftenberg attachment and show greater variation between plant accessions than do younger leaves, FEMS MICROBIOLOGY LETTERS, Vol: 362, ISSN: 0378-1097 Messens W, Bolton D, Frankel G, Liebana E, McLauchlin J, Morabito S, Oswald E, Threlfall EJet al., 2015, Defining pathogenic verocytotoxin-producing Escherichia coli (VTEC) from cases of human infection in the European Union, 2007-2010, EPIDEMIOLOGY AND INFECTION, Vol: 143, Pages: 1652-1661, ISSN: 0950-2688 Schreiber F, Kay S, Frankel G, Clare S, Goulding D, van de Vosse E, van Dissel JT, Strugnell R, Thwaites G, Kingsley RA, Dougan G, Baker Set al., 2015, The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322 Schroeder GN, Aurass P, Oates CV, Tate EW, Hartland EL, Flieger A, Frankel Get al., 2015, Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor, INFECTION AND IMMUNITY, Vol: 83, Pages: 3989-4002, ISSN: 0019-9567 So EC, Mattheis C, Tate EW, Frankel G, Schroeder GNet al., 2015, Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors, CANADIAN JOURNAL OF MICROBIOLOGY, Vol: 61, Pages: 617-635, ISSN: 0008-4166 Witcomb LA, Collins JW, McCarthy AJ, Frankel G, Taylor PWet al., 2015, Bioluminescent Imaging Reveals Novel Patterns of Colonization and Invasion in Systemic Escherichia coli K1 Experimental Infection in the Neonatal Rat, INFECTION AND IMMUNITY, Vol: 83, Pages: 4528-4540, ISSN: 0019-9567 Clements A, Stoneham CA, Furniss RCD, Frankel Get al., 2014, Enterohaemorrhagic Escherichia coli inhibits recycling endosome function and trafficking of surface receptors, CELLULAR MICROBIOLOGY, Vol: 16, Pages: 1693-1705, ISSN: 1462-5814 Collins JW, Chervaux C, Raymond B, Derrien M, Brazeilles R, Kosta A, Chambaud I, Crepin VF, Frankel Get al., 2014, Fermented Dairy Products Modulate Citrobacter rodentium-Induced Colonic Hyperplasia, JOURNAL OF INFECTIOUS DISEASES, Vol: 210, Pages: 1029-1041, ISSN: 0022-1899 Collins JW, Keeney KM, Crepin VE, Rathinam VAK, Fitzgerald KA, Finlay BB, Frankel Get al., 2014, Citrobacter rodentium: infection, inflammation and the microbiota, NATURE REVIEWS MICROBIOLOGY, Vol: 12, Pages: 612-623, ISSN: 1740-1526 Mousnier A, Schroeder GN, Stoneham CA, So EC, Garnett JA, Yu L, Matthews SJ, Choudhary JS, Hartland EL, Frankel Get al., 2014, A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases, MBIO, Vol: 5, ISSN: 2150-7511 Pallett MA, Berger CN, Pearson JS, Hartland EL, Frankel Get al., 2014, The Type III Secretion Effector NleF of Enteropathogenic Escherichia coli Activates NF-kappa B Early during Infection, INFECTION AND IMMUNITY, Vol: 82, Pages: 4878-4888, ISSN: 0019-9567 Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld J-C, Frankel G, Di Santo JPet al., 2014, The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells, IMMUNITY, Vol: 41, Pages: 776-788, ISSN: 1074-7613 Song-Zhao GX, Srinivasan N, Pott J, Baban D, Frankel G, Maloy KJet al., 2014, Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen, MUCOSAL IMMUNOLOGY, Vol: 7, Pages: 763-774, ISSN: 1933-0219 Stevens MP, Frankel GM, 2014, The Locus of Enterocyte Effacement and Associated Virulence Factors of Enterohemorrhagic Escherichia coli., Microbiol Spectr, Vol: 2