Filloux, Alain - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

研究领域

Our research project aims to tackle the problem of persistence and chronic infection by Pseudomonas aeruginosa. P. aeruginosa is a gram-negative bacterium found in various environments including soil, water and vegetation. Importantly it is an opportunistic human pathogen, responsible for numerous nosocomial infections in immuno-compromised patients. These infections are fatal in cystic fibrosis patients. Our project follows several research lines, which deal with essential molecular mechanisms involved in biofilm formation and type VI protein secretion. These two key processes are co-regulated and highly relevant for P. aeruginosa pathogenesis. The regulatory control involves signalling pathways associated with two-component regulatory systems and the intracellular second messenger c-di-GMP. We address these questions using multi-disciplinary approaches in molecular microbiology, genetics, cellular microbiology, structural biology and biochemistry.

近期论文

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Bernal P, Civantos C, Filloux A, Llamas MAet al., Type VI secretion in the plant growth promoting rhizobacteria Pseudomonas putida, FEMS Microbiology Congress 2015 Filloux AAM, Bernal P, Allsopp LP, Llamas MAet al., The Pseudomonas putida T6SS is a plant warden against phytopathogens, The ISME Journal, ISSN: 1751-7362 Chambonnier G, Roux L, Redelberger D, Fadel F, Filloux A, Sivaneson M, de Bentzmann S, Bordi Cet al., 2016, The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa, PLOS GENETICS, Vol: 12, ISSN: 1553-7404 Filloux A, Freemont P, 2016, Baseplates in contractile machines, NATURE MICROBIOLOGY, Vol: 1 Filloux A, Whitfield C, 2016, Editorial: The many wonders of the bacterial cell surface, FEMS MICROBIOLOGY REVIEWS, Vol: 40, Pages: 161-163, ISSN: 0168-6445 Gill SK, Hui K, Farne H, Garnett JP, Baines DL, Moore LSP, Holmes AH, Filloux A, Tregoning JSet al., 2016, Increased airway glucose increases airway bacterial load in hyperglycaemia, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Hachani A, Wood TE, Filloux A, 2016, Type VI secretion and anti-host effectors, CURRENT OPINION IN MICROBIOLOGY, Vol: 29, Pages: 81-93, ISSN: 1369-5274 Larrouy-Maumus G, Clements A, Filloux A, McCarthy RR, Mostowy Set al., 2016, Direct detection of lipid A on intact Gram-negative bacteria by MALDI-TOF mass spectrometry, JOURNAL OF MICROBIOLOGICAL METHODS, Vol: 120, Pages: 68-71, ISSN: 0167-7012 Lund-Palau H, Turnbull AR, Bush A, Bardin E, Cameron L, Soren O, Wierre-Gore N, Alton EWFW, Bundy JG, Connett G, Faust SN, Filloux A, Freemont P, Jones A, Khoo V, Morales S, Murphy R, Pabary R, Simbo A, Schelenz S, Takats Z, Webb J, Williams HD, Davies JCet al., 2016, Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches, EXPERT REVIEW OF RESPIRATORY MEDICINE, Vol: 10, Pages: 685-697, ISSN: 1747-6348 Planamente S, Salih O, Manoli E, Albesa-Jove D, Freemont PS, Filloux Aet al., 2016, TssA forms a gp6-like ring attached to the type VI secretion sheath, EMBO JOURNAL, Vol: 35, Pages: 1613-1627, ISSN: 0261-4189 Rasheed M, Garnett J, Perez-Dorado I, Muhl D, Filloux A, Matthews Set al., 2016, Crystal structure of the CupB6 adhesive tip from the chaperone-usher family of pili from Pseudomonas aeruginosa, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Vol: 1864, Pages: 1500-1505, ISSN: 1570-9639 Valentini M, Filloux A, 2016, Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria, Journal of Biological Chemistry, Vol: 291, Pages: 12547-12555, ISSN: 1083-351X Valentini M, Laventie BJ, Moscoso J, Jenal U, Filloux Aet al., 2016, The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility., PLoS Genet, Vol: 12 Aragon IM, Pérez-Mendoza D, Moscoso JA, Faure E, Guery B, Gallegos M-T, Filloux A, Ramos Cet al., 2015, Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections, Environmental Microbiology, Vol: 17, Pages: 4332-4351, ISSN: 1462-2920 Bosi E, Fondi M, Maida I, Perrin E, de Pascale D, Tutino ML, Parrilli E, Lo Giudice A, Filloux A, Fani Ret al., 2015, Genome-scale phylogenetic and DNA composition analyses of Antarctic Pseudoalteromonas bacteria reveal inconsistencies in current taxonomic affiliation, HYDROBIOLOGIA, Vol: 761, Pages: 85-95, ISSN: 0018-8158 Bouffartigues E, Moscoso JA, Duchesne R, Rosay T, Fito-Boncompte L, Gicquel G, Maillot O, Benard M, Bazire A, Brenner-Weiss G, Lesouhaitier O, Lerouge P, Dufour A, Orange N, Feuilloley MGJ, Overhage J, Filloux A, Chevalier Set al., 2015, The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level, FRONTIERS IN MICROBIOLOGY, Vol: 6, ISSN: 1664-302X Filloux A, 2015, Untitled, FEMS MICROBIOLOGY REVIEWS, Vol: 39, Pages: 1-1, ISSN: 0168-6445 Garnett JA, Muhl D, Douse CH, Hui K, Busch A, Omisore A, Yang Y, Simpson P, Marchant J, Waksman G, Matthews S, Filloux Aet al., 2015, Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation, Protein Science, Vol: 24, Pages: 670-687, ISSN: 1469-896X Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, Secor PR, Tseng BS, Scian M, Filloux A, Wozniak DJ, Howell PL, Parsek MRet al., 2015, Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix, Proceedings of the National Academy of Sciences of the United States of America, Vol: 112, Pages: 11353-11358, ISSN: 1091-6490 Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves Set al., 2015, Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network., mBio, Vol: 6, ISSN: 2150-7511