Gounaris, Kleoniki - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

Our research interests are in mechanisms employed by nematode parasites to modulate host immune responses. We recently discovered a panel of enzymes secreted by these pathogens which metabolise extracellular nucleotides, important triggers of innate immunity. Current projects are aimed at dissecting the role of these enzymes in regulation of purinergic signalling and mucosal inflammation.

近期论文

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Vaux R, Schnoeller C, Berkachy R, Roberts LB, Hagen J, Gounaris K, Selkirk MEet al., 2016, Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi., PLoS Pathog, Vol: 12 Rashidi NM, Scott MK, Scherf N, Krinner A, Kalchschmidt JS, Gounaris K, Selkirk ME, Roeder I, Lo Celso Cet al., 2014, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells, BLOOD, Vol: 124, Pages: 79-83, ISSN: 0006-4971 Afferson HC, Eleftheriou E, Selkirk ME, Gounaris Ket al., 2012, Trichinella spiralis Secreted Enzymes Regulate Nucleotide-Induced Mast Cell Activation and Release of Mouse Mast Cell Protease 1, INFECTION AND IMMUNITY, Vol: 80, Pages: 3761-3767, ISSN: 0019-9567 White RR, Miyata S, Papa E, Spooner E, Gounaris K, Selkirk ME, Artavanis-Tsakonas Ket al., 2011, Characterisation of the Trichinella spiralis Deubiquitinating Enzyme, TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner, PLOS NEGLECTED TROPICAL DISEASES, Vol: 5, ISSN: 1935-2727 Huang SC-C, Chan DTY, Smyth DJ, Ball G, Gounaris K, Selkirk MEet al., 2010, Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 40, Pages: 1619-1628, ISSN: 0020-7519 Rees-Roberts D, Mullen LM, Gounaris K, Selkirk MEet al., 2010, Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 40, Pages: 527-532, ISSN: 0020-7519 Guiliano DB, Oksov Y, Lustigman S, Gounaris K, Selkirk MEet al., 2009, Characterisation of novel protein families secreted by muscle stage larvae of Trichinella spiralis, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 515-524, ISSN: 0020-7519 Bruce AF, Gares MP, Selkirk ME, Gounaris Ket al., 2006, Functional characterisation of a nematode secreted GM2-activator protein, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 147, Pages: 224-229, ISSN: 0166-6851 Bruce AF, Gounaris K, 2006, Characterisation of a secreted N-acetyl-beta-hexosaminidase from Trichinella spiralis, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 145, Pages: 84-93, ISSN: 0166-6851 Selkirk ME, Gounaris K, 2006, Analysis of helminth immunomodulatory molecules by RNA interference, PARASITE IMMUNOLOGY, Vol: 28, Pages: 263-263, ISSN: 0141-9838 Gounaris K, Selkirk ME, 2005, Parasite nucleotide-metabolizing enzymes and host purinergic signalling, TRENDS IN PARASITOLOGY, Vol: 21, Pages: 17-21, ISSN: 1471-4922 Guiliano DB, Gounaris K, Selkirk ME, 2005, Identification of potential mediators of nurse cell transformation from Trichinella Spiralis, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 73, Pages: 336-337, ISSN: 0002-9637 Kock S, Gounaris K, 2005, Proteins secreted by Trichinella Spiralis alter nucleotide-induced migration of dendritic cells, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 73, Pages: 336-336, ISSN: 0002-9637 Gounaris K, Selkirk ME, Sadeghi SJ, 2004, A nucleotidase with unique catalytic properties is secreted by Trichinella spiralis, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 136, Pages: 257-264, ISSN: 0166-6851 Selkirk ME, Gounaris K, 2004, Adaptations of parasitic nematodes to mammalian host immunity, 4th International Nematology Congress, Publisher: BRILL, Pages: 589-600, ISSN: 1573-5869 Selkirk ME, Hussein AS, Chambers AE, Goulding D, Gares MP, Vasquez-Lopez C, Garate T, Parkhouse RME, Gounaris Ket al., 2004, Trichinella spiralis secretes a homologue of prosaposin, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 135, Pages: 49-56, ISSN: 0166-6851 Gounaris K, 2002, Nucleotidase cascades are catalyzed by secreted proteins of the parasitic nematode Trichinella spiralis, INFECTION AND IMMUNITY, Vol: 70, Pages: 4917-4924, ISSN: 0019-9567 Gounaris K, Thomas S, Najarro P, Selkirk MEet al., 2001, Secreted variant of nucleoside diphosphate kinase from the intracellular parasitic nematode Trichinella spiralis, INFECTION AND IMMUNITY, Vol: 69, Pages: 3658-3662, ISSN: 0019-9567 Smith VP, Selkirk ME, Gounaris K, 2000, A reversible protein phosphorylation system is present at the surface of infective larvae of the parasitic nematode Trichinella spiralis, FEBS LETTERS, Vol: 483, Pages: 104-108, ISSN: 0014-5793 Selkirk ME, Smith VP, Thomas GR, Gounaris Ket al., 1998, Resistance of filarial nematode parasites to oxidative stress, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 28, Pages: 1315-1332, ISSN: 0020-7519