fairweather, neil - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

We are interested in the mechanisms employed by pathogenic Clostridia to cause disease. We use molecular microbiology and other approaches to identify and characterise novel virulence factors, which may lead to their exploitation as targets for novel therapeutics. Currently the main focus of my lab is Clostridium difficile, which causes gastrointesinal infections of man and animals and which is particularly problematic in hospitals.

近期论文

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Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF, Douce GRet al., 2016, Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Serrano M, Crawshaw AD, Dembek M, Monteiro JM, Pereira FC, Pinho MG, Fairweather NF, Salgado PS, Henriques AOet al., 2016, The SpoIIQ-SpoIIIAH complex of Clostridium difficile controls forespore engulfment and late stages of gene expression and spore morphogenesis, MOLECULAR MICROBIOLOGY, Vol: 100, Pages: 204-228, ISSN: 0950-382X Charlton TM, Kovacs-Simon A, Michell SL, Fairweather NF, Tate EWet al., 2015, Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation, CHEMISTRY & BIOLOGY, Vol: 22, Pages: 1562-1573, ISSN: 1074-5521 Couchman EC, Browne HP, Dunn M, Lawley TD, Songer JG, Hall V, Petrovska L, Vidor C, Awad M, Lyras D, Fairweather NFet al., 2015, Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci, BMC GENOMICS, Vol: 16, ISSN: 1471-2164 Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF, Fagan RPet al., 2015, High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile, mBio, Vol: 6, ISSN: 2161-2129 Peltier J, Shaw HA, Couchman EC, Dawson LF, Yu L, Choudhary JS, Kaever V, Wren BW, Fairweather NFet al., 2015, Cyclic diGMP Regulates Production of Sortase Substrates of Clostridium difficile and Their Surface Exposure through Zmpl Protease-mediated Cleavage, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 24453-24469, ISSN: 0021-9258 Sekulovic O, Bedoya MO, Fivian-Hughes AS, Fairweather NF, Fortier L-Cet al., 2015, The Clostridium difficile cell wall protein CwpV confers phase-variable phage resistance, MOLECULAR MICROBIOLOGY, Vol: 98, Pages: 329-342, ISSN: 0950-382X Willing SE, Candela T, Shaw HA, Seager Z, Mesnage S, Fagan RP, Fairweather NFet al., 2015, Clostridium difficile surface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII, MOLECULAR MICROBIOLOGY, Vol: 96, Pages: 596-608, ISSN: 0950-382X Willing SE, Richards EJ, Sempere L, Dale AG, Cutting SM, Fairweather NFet al., 2015, Increased toxin expression in a Clostridium difficile mfd mutant, BMC MICROBIOLOGY, Vol: 15, ISSN: 1471-2180 Fagan RP, Fairweather NF, 2014, Biogenesis and functions of bacterial S-layers, NATURE REVIEWS MICROBIOLOGY, Vol: 12, Pages: 211-222, ISSN: 1740-1526 Phetcharaburanin J, Hong HA, Colenutt C, Bianconi I, Sempere L, Permpoonpattana P, Smith K, Dembek M, Tan S, Brisson M-C, Brisson AR, Fairweather NF, Cutting SMet al., 2014, The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile, MOLECULAR MICROBIOLOGY, Vol: 92, Pages: 1025-1038, ISSN: 0950-382X Chen K, d'Arc S, Setty N, Bamford K, Fairweather N, Tyrrell-Price Jet al., 2013, In Recurrent C. difficile, the CRP Response to the Primary C. difficile Infection Predicts Whether the Same Strain or a Different Strain will Cause a Second Infection, DIGESTIVE DISEASES AND SCIENCES, Vol: 58, Pages: 1683-1688, ISSN: 0163-2116 Dembek M, Stabler RA, Witney AA, Wren BW, Fairweather NFet al., 2013, Transcriptional Analysis of Temporal Gene Expression in Germinating Clostridium difficile 630 Endospores, PLOS ONE, Vol: 8, ISSN: 1932-6203 Permpoonpattana P, Phetcharaburanin J, Mikelsone A, Dembek M, Tan S, Brisson M-C, La Ragione R, Brisson AR, Fairweather N, Hong HA, Cutting SMet al., 2013, Functional Characterization of Clostridium difficile Spore Coat Proteins, JOURNAL OF BACTERIOLOGY, Vol: 195, Pages: 1492-1503, ISSN: 0021-9193 Tulli L, Marchi S, Petracca R, Shaw HA, Fairweather NF, Scarselli M, Soriani M, Leuzzi Ret al., 2013, CbpA: a novel surface exposed adhesin of Clostridium difficile targeting human collagen, CELLULAR MICROBIOLOGY, Vol: 15, Pages: 1674-1687, ISSN: 1462-5814 Dang THT, Fagan RP, Fairweather NF, Tate EWet al., 2012, Novel inhibitors of surface layer processing in Clostridium difficile, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 20, Pages: 614-621, ISSN: 0968-0896 Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G, Lawley TDet al., 2012, The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor, INFECTION AND IMMUNITY, Vol: 80, Pages: 2704-2711, ISSN: 0019-9567 Dembek M, Reynolds CB, Fairweather NF, 2012, Clostridium difficile Cell Wall Protein CwpV Undergoes Enzyme-independent Intramolecular Autoproteolysis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, Pages: 1538-1544, ISSN: 0021-9258 Tierney R, Nakai T, Parkins CJ, Caposio P, Fairweather NF, Sesardic D, Jarvis MAet al., 2012, A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice, VACCINE, Vol: 30, Pages: 3047-3052, ISSN: 0264-410X Fagan RP, Fairweather NF, 2011, Clostridium difficile Has Two Parallel and Essential Sec Secretion Systems, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 27483-27493, ISSN: 0021-9258