Endres, Robert - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

The research interests of my group are the quantitative understanding of sensing and signalling in biological cells based on physical principles. While chemical sensing by cell-surface receptors and their intracellular pathways are often well characterized, it is rather unexplored what the physical limitations of sensing are and how constraints from the physical environment affect the design of sensory systems and pathways. In addition to chemicals, cells also sense mechanical stimuli, including shear from fluid flow, forces from cell-cell and cell-substrate adhesion, as well as physical properties of bulky objects. These stimuli are important for embryonic development, tissue formation and repair, and our immune response. In general, very little is known about how these types of stimuli are sensed and encoded in the biochemical signalling pathways. To conduct our research, we use computational tools from statistical physics, in combination with explicit biological data from experimental collaborators.

近期论文

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Micali G, Endres RG, 2016, Bacterial chemotaxis: information processing, thermodynamics, and behavior, CURRENT OPINION IN MICROBIOLOGY, Vol: 30, Pages: 8-15, ISSN: 1369-5274 Richards DM, Endres RG, 2016, Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 6113-6118, ISSN: 0027-8424 Aquino G, Wingreen NS, Endres RG, 2015, Know the Single-Receptor Sensing Limit? Think Again., J Stat Phys, Vol: 162, Pages: 1353-1364, ISSN: 0022-4715 Eismann S, Endres RG, 2015, Protein Connectivity in Chemotaxis Receptor Complexes, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X Endres RG, 2015, Bistability: requirements on cell-volume, protein diffusion, and thermodynamics., PLoS One, Vol: 10 Micali G, Aquino G, Richards DM, Endres RGet al., 2015, Accurate Encoding and Decoding by Single Cells: Amplitude Versus Frequency Modulation, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X Aquino G, Tweedy L, Heinrich D, Endres RGet al., 2014, Memory improves precision of cell sensing in fluctuating environments, SCIENTIFIC REPORTS, Vol: 4, ISSN: 2045-2322 Clausznitzer D, Micali G, Neumann S, Sourjik V, Endres RGet al., 2014, Predicting Chemical Environments of Bacteria from Receptor Signaling, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X Fan S, Endres RG, 2014, A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides, INTERFACE FOCUS, Vol: 4, ISSN: 2042-8898 Ojkic N, Lopez-Garrido J, Pogliano K, Endres RGet al., 2014, Bistable Forespore Engulfment in Bacillus subtilis by a Zipper Mechanism in Absence of the Cell Wall, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X Richards DM, Endres RG, 2014, The Mechanism of Phagocytosis: Two Stages of Engulfment, BIOPHYSICAL JOURNAL, Vol: 107, Pages: 1542-1553, ISSN: 0006-3495 De Palo G, Endres RG, 2013, Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells, PLOS COMPUTATIONAL BIOLOGY, Vol: 9, ISSN: 1553-7358 Endres RG, 2013, Physical Principles in Sensing and Signaling, Publisher: OUP Oxford, ISBN: 9780199600632 Pageon SV, Aquino G, Lagrue K, Koehler K, Endres RG, Davis DMet al., 2013, Dynamics of Natural Killer Cell Receptor Revealed by Quantitative Analysis of Photoswitchable Protein, BIOPHYSICAL JOURNAL, Vol: 105, Pages: 1987-1996, ISSN: 0006-3495 Raymond B, Young JC, Pallett M, Endres RG, Clements A, Frankel Get al., 2013, Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors, TRENDS IN MICROBIOLOGY, Vol: 21, Pages: 430-439, ISSN: 0966-842X Tweedy L, Meier B, Stephan J, Heinrich D, Endres RGet al., 2013, Distinct cell shapes determine accurate chemotaxis, SCIENTIFIC REPORTS, Vol: 3, ISSN: 2045-2322 Dart AE, Tollis S, Bright MD, Frankel G, Endres RGet al., 2012, The motor protein myosin 1G functions in Fc gamma R-mediated phagocytosis, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 6020-6029, ISSN: 0021-9533 Endres RG, 2012, Intracellular chemical gradients: morphing principle in bacteria, BMC BIOPHYSICS, Vol: 5, ISSN: 2046-1682 Endres RG, 2012, Signaling Crosstalk: New Insights Require New Vocabulary, BIOPHYSICAL JOURNAL, Vol: 103, Pages: 2241-2242, ISSN: 0006-3495 Kalaji R, Wheeler AP, Erasmus JC, Lee SY, Endres RG, Cramer LP, Braga VMMet al., 2012, ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape, BIOLOGY OF THE CELL, Vol: 104, Pages: 435-451, ISSN: 0248-4900