Curry, Stephen - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

I am a structural biologist in the Faculty of Natural Sciences. My group works on a variety of fascinating problems related to different aspects of the replication of RNA viruses such as foot-and-mouth disease virus and the dreaded norovirus (the winter vomiting bug). We mainly use X-ray crystallography to determine the structures of proteins molecules, to shed new light on how they work. Our current projects include structural analysis of host-virus protein interactions that are crucial to initiate translation of the viral RNA, the process by which new viral proteins are synthesised in infected cells. We are also interested in the viral enzymes produced once translation gets going. Most recently we have been the NS6 protease from the mouse norovirus (wich is very similar to its human counterpart) and the role of an unusual norovirus protein, VPg, in translation initiation. From 2011-15 I was Director of Undergraduate Studies in the Department of Life Sciences. Although currently on sabbatical, my main teaching activities are usually in the undergraduate degree program in Biochemistry. I am also involved in postgraduate teaching on Masters courses (e.g. MRes in Structural Biology) and PhD student supervision. My research and teaching interests are combined with a strong interest in exploring the wider role of science in society using a variety of media. I have made and presented a number of science videos. I also write regularly about science and the scientific life in the Guardian and on my Reciprocal Space blog

研究领域

My group is interested in structural biology, primarily applying protein crystallography to tackle a range of fundamental problems in biology and biochemistry, though some of them have potentially interesting applications. Our work is mainly devoted to the investigation aspects of viral translation initiation and protein-drug interactions. We aim to reveal the structural bases of these processes in order to elucidate their molecular mechanisms. Current projects include: Protein-RNA and protein-protein interactions involved in picornaviral translation initiation Viral protease structure and mechanism

近期论文

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Hosmillo M, Sweeney TR, Chaudhry Y, Leen E, Curry S, Goodfellow I, Cho K-Oet al., 2016, The RNA Helicase eIF4A Is Required for Sapovirus Translation, JOURNAL OF VIROLOGY, Vol: 90, Pages: 5200-5204, ISSN: 0022-538X Lariviere V, Kiermer V, MacCallum CJ, McNutt M, Patterson M, Pulverer B, Swaminathan S, Curry Set al., 2016, A simple proposal for the publication of journal citation distributions, Publisher: bioRxiv Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry Set al., 2016, A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation, PLOS PATHOGENS, Vol: 12, ISSN: 1553-7366 Yang J, Leen EN, Maree FF, Curry Set al., 2016, Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus, Publisher: PeerJ Preprints Yang J, Leen EN, Maree FF, Curry Set al., 2016, Crystal structure of the 3C protease from Southern African Territories type foot-and-mouth disease virus 2, PEERJ, Vol: 4, ISSN: 2167-8359 Curry S, 2015, Structural biology: A century-long journey into an unseen world, Interdisciplinary Science Reviews, Vol: 40, Pages: 308-328, ISSN: 0308-0188 Curry S, Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IGet al., 2015, A conserved interaction between a C-terminal motif in Norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation, Publisher: bioRxiv Fernandes H, Leen EN, Cromwell H, Pfeil M-P, Curry Set al., 2015, Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease-substrate interactions, PEERJ, Vol: 3, ISSN: 2167-8359 Chung L, Bailey D, Leen EN, Emmott EP, Chaudhry Y, Roberts LO, Curry S, Locker N, Goodfellow IGet al., 2014, Norovirus Translation Requires an Interaction between the C Terminus of the Genome-linked Viral Protein VPg and Eukaryotic Translation Initiation Factor 4G, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 21738-21750, ISSN: 0021-9258 Curry S, 2014, Open access--reasons to be cheerful: a reply to Agrawal., Trends Plant Sci, Vol: 19, Pages: 196-197 Joshi A, Esteve V, Buckroyd AN, Blatter M, Allain FH-T, Curry Set al., 2014, Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB), PEERJ, Vol: 2, ISSN: 2167-8359 Mickleburgh I, Kafasla P, Cherny D, Llorian M, Curry S, Jackson RJ, Smith CWJet al., 2014, The organization of RNA contacts by PTB for regulation of FAS splicing, NUCLEIC ACIDS RESEARCH, Vol: 42, Pages: 8605-8620, ISSN: 0305-1048 Rosell NRR, Mokhlesi L, Milton NE, Sweeney TR, Zunszain PA, Curry S, Leatherbarrow RJet al., 2014, Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 24, Pages: 490-494, ISSN: 0960-894X Curry S, 2013, Open access: Brave new world requires bravery, Insights, Vol: 26, Pages: 22-27 Leen EN, Kwok KYR, Birtley JR, Simpson PJ, Subba-Reddy CV, Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, Young JC, Chung LMW, Marchant J, Roberts LO, Kao CC, Matthews S, Goodfellow IG, Curry Set al., 2013, Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins, JOURNAL OF VIROLOGY, Vol: 87, Pages: 5318-5330, ISSN: 0022-538X Porta C, Xu X, Loureiro S, Paramasivam S, Ren J, Al-Khalil T, Burman A, Jackson T, Belsham GJ, Curry S, Lomonossoff GP, Parida S, Paton D, Li Y, Wilsden G, Ferris N, Owens R, Kotecha A, Fry E, Stuart DI, Charleston B, Jones IMet al., 2013, Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity, JOURNAL OF VIROLOGICAL METHODS, Vol: 187, Pages: 406-412, ISSN: 0166-0934 Zhou Z, Mogensen MM, Powell PP, Curry S, Wileman Tet al., 2013, Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport, JOURNAL OF VIROLOGY, Vol: 87, Pages: 11721-11729, ISSN: 0022-538X Kafasla P, Mickleburgh I, Llorian M, Coelho M, Gooding C, Cherny D, Joshi A, Kotik-Kogan O, Curry S, Eperon IC, Jackson RJ, Smith CWJet al., 2012, Defining the roles and interactions of PTB, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 40, Pages: 815-820, ISSN: 0300-5127 Leen EN, Baeza G, Curry S, 2012, Structure of a Murine Norovirus NS6 Protease-Product Complex Revealed by Adventitious Crystallisation, PLOS ONE, Vol: 7, ISSN: 1932-6203 Martino L, Pennell S, Kelly G, Bui TTT, Kotik-Kogan O, Smerdon SJ, Drake AF, Curry S, Conte MRet al., 2012, Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein, NUCLEIC ACIDS RESEARCH, Vol: 40, Pages: 1381-1394, ISSN: 0305-1048