Cota, Ernesto - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

The adhesion of microbial pathogens to their target host cells is a highly specific process and a prerequisite for infection. To perform this function, pathogens have evolved molecules that display an intimate surface complementarity to extracellular host cell proteins, either in the external membrane or the extracellular matrix. In many cases, these microbial adhesins are able to replace native interactions in the host and trigger signalling cascades that 'cement' their binding and/or promote their internalisation into particular cell types. Importantly, these proteins are also among the first to interact with the immune system. As such, they represent good candidates for immunisation therapies and targets for drug design. Our research is focused in determining the structures of these molecules, their complexes with host cell receptors and to investigate the events that occur during the establishment of the infection.

近期论文

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Hagiwara Y, Sieverling L, Hanif F, Anton J, Dickinson ER, Bui TTT, Andreeva A, Barran PE, Cota E, Nikolova PVet al., 2016, Consequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studies, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Hoyer LL, Cota E, 2016, Candida albicans Agglutinin-Like Sequence (AIs) Family Vignettes: A Review of AIs Protien Structure and Function, FRONTIERS IN MICROBIOLOGY, Vol: 7, ISSN: 1664-302X Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Hoefs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Foerster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Haeder A, Kurzai O, Luo T, Krueger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JRet al., 2016, Candidalysin is a fungal peptide toxin critical for mucosal infection, NATURE, Vol: 532, Pages: 64-+, ISSN: 0028-0836 Zhao W, Jamshidiha M, Lanyon-Hogg T, Recchi C, Cota E, Tate EWet al., 2016, Direct Targeting of the Ras GTPase Superfamily through Structure-Based Design., Curr Top Med Chem Cota E, Hoyer LL, 2015, The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis, FUTURE MICROBIOLOGY, Vol: 10, Pages: 1635-1648, ISSN: 1746-0913 Douse CH, Vrielink N, Zhang W, Cota E, Tate EWet al., 2015, Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex, CHEMMEDCHEM, Vol: 10, Pages: 134-143, ISSN: 1860-7179 Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AAet al., 2015, The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 12147-12164, ISSN: 0021-9258 Berry AA, Yang Y, Pakharukova N, Garnett JA, Lee W-C, Cota E, Marchant J, Roy S, Tuittila M, Liu B, Inman KG, Ruiz-Perez F, Mandomando I, Nataro JP, Zavialov AV, Matthews Set al., 2014, Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli, PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366 Douse CH, Maas SJ, Thomas JC, Garnett JA, Sun Y, Cota E, Tate EWet al., 2014, Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction, ACS CHEMICAL BIOLOGY, Vol: 9, Pages: 2204-2209, ISSN: 1554-8929 Hoyer LL, Oh S-H, Jones R, Cota Eet al., 2014, A proposed mechanism for the interaction between the Candida albicans Als3 adhesin and streptococcal cell wall proteins, FRONTIERS IN MICROBIOLOGY, Vol: 5, ISSN: 1664-302X Lin J, Oh S-H, Jones R, Garnett JA, Salgado PS, Rusnakova S, Matthews SJ, Hoyer LL, Cota Eet al., 2014, The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 18401-18412, ISSN: 0021-9258 Cota E, 2012, Candida albicans Als adhesins - New insights from recent structural and functional data, 11th ASM Conference on Candida and Candidiasis Douse CH, Green JL, Salgado PS, Simpson PJ, Thomas JC, Langsley G, Holder AA, Tate EW, Cota Eet al., 2012, Regulation of the Plasmodium Motor Complex PHOSPHORYLATION OF MYOSIN A TAIL-INTERACTING PROTEIN (MTIP) LOOSENS ITS GRIP ON MyoA, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, Pages: 36968-36977, ISSN: 0021-9258 Garnett JA, Martinez-Santos VI, Saldana Z, Pape T, Hawthorne W, Chan J, Simpson PJ, Cota E, Puente JL, Giron JA, Matthews Set al., 2012, Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 3950-3955, ISSN: 0027-8424 JA, Simpson PJ, Taylor J, Benjamin SV, Tagliaferri C, Cota E, Chen Y-YM, Wu H, Matthews Set al., 2012, Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm Garnett formation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 417, Pages: 421-426, ISSN: 0006-291X James E, Liu M, Sheppard C, Mekler V, Camara B, Liu B, Simpson P, Cota E, Severinov K, Matthews S, Wigneshweraraj Set al., 2012, Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2, MOLECULAR CELL, Vol: 47, Pages: 755-766, ISSN: 1097-2765 Liu B, Garnett JA, Lee W-C, Lin J, Salgado P, Taylor J, Xu Y, Lambert S, Cota E, Matthews Set al., 2012, Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 421, Pages: 208-213, ISSN: 0006-291X Moyes DL, Murciano C, Tang S, Bader O, Moran G, Cota E, Waechtler B, Wilson D, Hube B, Naglik JRet al., 2012, Epithelial responses to Candida albicans, MYCOSES, Vol: 55, Pages: 2-3, ISSN: 0933-7407 Salek-Ardakani S, Cota E, Bignell E, 2012, Host-fungal interactions: key players of antifungal immunity., Expert Rev Anti Infect Ther, Vol: 10, Pages: 149-151 Simpson PJ, Cota E, Bolanos-Garcia VM, 2012, H-1, C-13 and N-15 resonance assignments of the kinetochore localisation domain of BUBR1, a central component of the spindle assembly checkpoint, BIOMOLECULAR NMR ASSIGNMENTS, Vol: 6, Pages: 115-118, ISSN: 1874-2718