Clements, Abigail - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

个人简介

Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp). Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

研究领域

Shigella species are responsible for bacillary dysentery or shigellosis, a disease estimated to cause nearly 1 million deaths per year. Shigella species are closely related to the pathogenic E. coli, with Shigella and enteroinvasive E. coli being clinically indistinguishable. These pathogens utilise a common infection strategy whereby bacterial effector proteins are delivered directly into the host cell via a type 3 secretion system (T3SS), a strategy also shared by many other pathogenic bacteria (e.g. Salmonella, Yersinia and Vibrio spp). Research in my laboratory currently focuses on structure/function studies of effector proteins that are common between the extracellular pathogenic E. coli (enteropathogenic and enterohaemorrhagic E. coli) and the intracellular enteroinvasive E. coli and Shigella species. The signalling pathways targeted by effectors that are shared by intracellular and extracellular pathogens represent fundamental processes required for infection such as subversion of cellular trafficking and regulation of apoptosis.

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Furniss RCD, Slater S, Frankel G, Clements Aet al., 2016, Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection, JOURNAL OF MOLECULAR BIOLOGY, Vol: 428, Pages: 3399-3407, ISSN: 0022-2836 Larrouy-Maumus G, Clements A, Filloux A, McCarthy RR, Mostowy Set al., 2016, Direct detection of lipid A on intact Gram-negative bacteria by MALDI-TOF mass spectrometry, JOURNAL OF MICROBIOLOGICAL METHODS, Vol: 120, Pages: 68-71, ISSN: 0167-7012 Mavridou DA, Gonzalez D, Clements A, Foster KRet al., 2016, The pUltra plasmid series: A robust and flexible tool for fluorescent labeling of Enterobacteria., Plasmid Clements A, Stoneham CA, Furniss RCD, Frankel Get al., 2014, Enterohaemorrhagic Escherichia coli inhibits recycling endosome function and trafficking of surface receptors, CELLULAR MICROBIOLOGY, Vol: 16, Pages: 1693-1705, ISSN: 1462-5814 Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel Get al., 2014, The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation, NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723 Clements A, Berger CN, Lomma M, Frankel Get al., 2013, Type 3 secretion effectors, Escherichia coliPathotypes and Principles of Pathogenesis, Editors: Donnenberg, ISBN: 978-0-12-397048-0 Raymond B, Young JC, Pallett M, Endres RG, Clements A, Frankel Get al., 2013, Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors, TRENDS IN MICROBIOLOGY, Vol: 21, Pages: 430-439, ISSN: 0966-842X Velkov T, Soon RL, Chong PL, Huang JX, Cooper MA, Azad MAK, Baker MA, Thompson PE, Roberts K, Nation RL, Clements A, Strugnell RA, Li Jet al., 2013, Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A, INNATE IMMUNITY, Vol: 19, Pages: 265-277, ISSN: 1753-4259 Clements A, Young JC, Constantinou N, Frankel Get al., 2012, Infection strategies of enteric pathogenic Escherichia coli., Gut Microbes, Vol: 3, Pages: 71-87 Wong ARC, Clements A, Raymond B, Crepin VF, Frankel Get al., 2012, The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH, MBIO, Vol: 3, ISSN: 2150-7511 Clements A, Smollett K, Lee SF, Hartland EL, Lowe M, Frankel Get al., 2011, EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function, CELLULAR MICROBIOLOGY, Vol: 13, Pages: 1429-1439, ISSN: 1462-5814 Robinson KS, Clements A, Williams AC, Berger CN, Frankel Get al., 2011, Bax Inhibitor 1 in apoptosis and disease, ONCOGENE, Vol: 30, Pages: 2391-2400, ISSN: 0950-9232 Wilksch JJ, Yang J, Clements A, Gabbe JL, Short KR, Cao H, Cavaliere R, James CE, Whitchurch CB, Schembri MA, Chuah MLC, Liang Z-X, Wijburg OL, Jenney AW, Lithgow T, Strugnell RAet al., 2011, MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression, PLOS PATHOGENS, Vol: 7, ISSN: 1553-7366 Alcock F, Clements A, Webb C, Lithgow Tet al., 2010, Tinkering Inside the Organelle, SCIENCE, Vol: 327, Pages: 649-650, ISSN: 0036-8075 Clements A, Bursac D, Gatsos X, Perry AJ, Civciristov S, Celik N, Likic VA, Poggio S, Jacobs-Wagner C, Strugnell RA, Lithgow Tet al., 2009, The reducible complexity of a mitochondrial molecular machine, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 15791-15795, ISSN: 0027-8424 Clements A, Gaboriaud F, Duval JFL, Farn JL, Jenney AW, Lithgow T, Wijburg OLC, Hartland EL, Strugnell RAet al., 2008, The Major Surface-Associated Saccharides of Klebsiella pneumoniae Contribute to Host Cell Association, PLOS ONE, Vol: 3, ISSN: 1932-6203 Clements A, Jenney AW, Farn JL, Brown LE, Deliyannis G, Hartland EL, Pearse MJ, Maloney MB, Wesselingh SL, Wijburg OL, Strugnell RAet al., 2008, Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections, VACCINE, Vol: 26, Pages: 5649-5653, ISSN: 0264-410X Clements A, Tull D, Jenney AW, Farn JL, Kim S-H, Bishop RE, McPhee JB, Hancock REW, Hartland EL, Pearse MJ, Wijburg OLC, Jackson DC, McConville MJ, Strugnell RAet al., 2007, Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 15569-15577, ISSN: 0021-9258 Carter DM, Miousse IR, Gagnon J-N, Martinez E, Clements A, Lee J, Hancock MA, Gagnon H, Pawelek PD, Coulton JWet al., 2006, Interactions between TonB from Escherichia coli and the Periplasmic Protein FhuD, Journal of Biological Chemistry, Vol: 281, Pages: 35413-35424, ISSN: 0021-9258