Christophides, George K. - Imperial College London - Department of Life Sciences, Biology, Ecology and Environmental Biology, Microbiology, Zoology

个人简介

I received my PhD in Molecular Biology from the University of Athens and continued my research career as a Marie Curie postdoctoral fellow at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. I moved to Imperial College London in 2005, where I am currently Professor and Chair of Infectious Disease and Immunity. I am also Adjunct Professor and Associate Dean at the Cyprus Institute, Cyprus. I am interested in the biology of infectious diseases, especially vector-borne, and how this may be affected by human interventions and the changing environment. Through my research, I wish to contribute to public health innovations and in improving human life. In addition to directing the VigiLab, I am convening a final year course at Imperial College on Advanced Topics in Infection and Immunity and lecturing in Immunology and in Advanced Topics in Parasitology and Vector Biology courses.

研究领域

Our research focuses on vector-borne diseases, including those caused by parasites and viruses. We are particularly interested on the interactions between the innate immune system of disease vectors and the pathogens. Our central focus is malaria, which threatens almost half of the global population and kills about 700,000 people every year, mostly children below 5 in sub-Saharan Africa. It is caused by the protozoan parasite, Plasmodium, which is transmitted to humans through Anopheles mosquitoes. For our research we use the full suite of tools available to modern biological research including genomics, functional genomics, population genetics, reverse genetics, molecular and cell biology, biochemistry and bioinformatics, integrated in a systems biology framework.

近期论文

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Gendrin MEM, Christophides, Linenberg, Inbaret al., Larval diet affects mosquito development and permissiveness to Plasmodium infection, Scientific Reports, ISSN: 2045-2322 Gendrin MEM, Turlure F, Rodgers FH, Cohuet A, Morlais I, Christophides GKet al., The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium, Journal of Innate Immunity, ISSN: 1662-8128 Akorli J, Gendrin M, Pels NAP, Yeboah-Manu D, Christophides GK, Wilson MDet al., 2016, Seasonality and Locality Affect the Diversity of Anopheles gambiae and Anopheles coluzzii Midgut Microbiota from Ghana, PLOS ONE, Vol: 11, ISSN: 1932-6203 Erguler K, Smith-Unna SE, Waldock J, Proestos Y, Christophides GK, Lelieveld J, Parham PEet al., 2016, Large-Scale Modelling of the Environmentally-Driven Population Dynamics of Temperate Aedes albopictus (Skuse), PLOS ONE, Vol: 11, ISSN: 1932-6203 Gendrin M, Yerbanga RS, Ouedraogo JB, Lefèvre T, Cohuet A, Christophides GKet al., 2016, Differential Effects of Azithromycin, Doxycycline, and Cotrimoxazole in Ingested Blood on the Vectorial Capacity of Malaria Mosquitoes., Open Forum Infect Dis, Vol: 3 Habtewold T, Duchateau L, Christophides GK, 2016, Flow cytometry analysis of the microbiota associated with the midguts of vector mosquitoes, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305 Kohl A, Pondeville E, Schnettler E, Crisanti A, Supparo C, Christophides GK, Kersey PJ, Maslen GL, Takken W, Koenraadt CJM, Oliva CF, Busquets N, Abad FX, Failloux A-B, Levashina EA, Wilson AJ, Veronesi E, Pichard M, Marsh SA, Simard F, Vernick KDet al., 2016, Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements, PATHOGENS AND GLOBAL HEALTH, Vol: 110, ISSN: 2047-7724 Lombardo F, Christophides GK, 2016, Novel factors of Anopheles gambiae haemocyte immune response to Plasmodium berghei infection, PARASITES & VECTORS, Vol: 9, ISSN: 1756-3305 Povelones M, Osta MA, Christophides GK, 2016, The Complement System of Malaria Vector Mosquitoes, Editors: Raikhel, Publisher: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, Pages: 223-242 Abay SM, Dahiya N, Dembo E, Dori G, Christophides G, Esposito F, Lucantoni L, Lupidi G, Ogboi S, Ouedraogo R, Ouedraogo J-B, Sinisi A, Taglialatela-Scafati O, Yerbanga S, Habluetzel Aet al., 2015, Malaria transmission blocking activity of sesquiterpene lactones from Vernonia amygdalina, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 20, Pages: 150-151, ISSN: 1360-2276 Abay SM, Lucantoni L, Dahiya N, Dori G, Dembo EG, Esposito F, Lupidi G, Ogboi S, Ouedraogo RK, Sinisi A, Taglialatela-Scafati O, Yerbanga RS, Bramucci M, Quassinti L, Ouedraogo JB, Christophides G, Habluetzel Aet al., 2015, Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds, MALARIA JOURNAL, Vol: 14, ISSN: 1475-2875 Akinosoglou KA, Bushell ESC, Ukegbu CV, Schlegelmilch T, Cho J-S, Redmond S, Sala K, Christophides GK, Vlachou Det al., 2015, Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission, CELLULAR MICROBIOLOGY, Vol: 17, Pages: 254-268, ISSN: 1462-5814 Dahiya N, Tapanelli S, Chianese G, Abay SM, Taglialatela-Scafati O, Esposito F, Lupidi G, Christophides G, Lucantoni L, Yerbanga SR, Habluetzel Aet al., 2015, Transmission blocking effects of Azadirachta indica limonoids on early sporogonic development of Plasmodium: activity and bioavailability of seed fractions and isolated compounds, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 20, Pages: 178-179, ISSN: 1360-2276 Dembo EG, Abay SM, Dahiya N, Ogboi JS, Christophides GK, Lupidi G, Chianese G, Lucantoni L, Habluetzel Aet al., 2015, Impact of repeated NeemAzal (R)-treated blood meals on the fitness of Anopheles stephensi mosquitoes, Parasites & Vectors, Vol: 8, ISSN: 1756-3305 Gendrin M, Rodgers FH, Yerbanga RS, Ouedraogo JB, Basanez M-G, Cohuet A, Christophides GKet al., 2015, Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria, Nature Communications, Vol: 6, ISSN: 2041-1723 Giraldo-Calderon GI, Emrich SJ, MacCallum RM, Maslen G, Dialynas E, Topalis P, Ho N, Gesing S, Madey G, Collins FH, Lawson Det al., 2015, VectorBase: an updated bioinformatics resource for invertebrate vectors and other organisms related with human diseases, NUCLEIC ACIDS RESEARCH, Vol: 43, Pages: D707-D713, ISSN: 0305-1048 Habtewold T, Groom Z, Duchateau L, Christophides GKet al., 2015, Detection of viable plasmodium ookinetes in the midguts of anopheles coluzzi using PMA-qrtPCR, PARASITES & VECTORS, Vol: 8, ISSN: 1756-3305 Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J, Arca B, Arensburger P, Artemov G, Assour LA, Basseri H, Berlin A, Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A, Chan CS, Chauve C, Chiu JC, Christensen M, Costantini C, Davidson VLM, Deligianni E, Dottorini T, Dritsou V, Gabriel SB, Guelbeogo WM, Hall AB, Han MV, Hlaing T, Hughes DST, Jenkins AM, Jiang X, Jungreis I, Kakani EG, Kamali M, Kemppainen P, Kennedy RC, Kirmitzoglou IK, Koekemoer LL, Laban N, Langridge N, Lawniczak MKN, Lirakis M, Lobo NF, Lowy E, MacCallum RM, Mao C, Maslen G, Mbogo C, McCarthy J, Michel K, Mitchell SN, Moore W, Murphy KA, Naumenko AN, Nolan T, Novoa EM, O'Loughlin S, Oringanje C, Oshaghi MA, Pakpour N, Papathanos PA, Peery AN, Povelones M, Prakash A, Price DP, Rajaraman A, Reimer LJ, Rinker DC, Rokas A, Russell TL, Sagnon N, Sharakhova MV, Shea T, Simao FA, Simard F, Slotman MA, Somboon P, Stegniy V, Struchiner CJ, Thomas GWC, Tojo M, Topalis P, Tubio JMC, Unger MF, Vontas J, Walton C, Wilding CS, Willis JH, Wu Y-C, Yan G, Zdobnov EM, Zhou X, Catteruccia F, Christophides GK, Collins FH, Cornman RS, Crisanti A, Donnelly MJ, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Hansen IA, Howell PI, Kafatos FC, Kellis M, Lawson D, Louis C, Luckhart S, Muskavitch MAT, Ribeiro JM, Riehle MA, Sharakhov IV, Tu Z, Zwiebel LJ, Besansky NJet al., 2015, Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes, SCIENCE, Vol: 347, ISSN: 0036-8075 Parham PE, Waldock J, Christophides GK, Hemming D, Agusto F, Evans KJ, Fefferman N, Gaff H, Gumel A, LaDeau S, Lenhart S, Mickens RE, Naumova EN, Ostfeld RS, Ready PD, Thomas MB, Velasco-Hernandez J, Michael Eet al., 2015, Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436 Parham PE, Waldock J, Christophides GK, Michael Eet al., 2015, Climate change and vector-borne diseases of humans Preface, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436