Baldwin, Geoffrey - Imperial College London - Department of Life Sciences, Biochemistry and Biotechnology

研究领域

Research work in the Baldwin lab focuses on the development of synthetic biology approaches to facilitate the engineering of new biological systems for real-world applications. To this end we have developed foundational tools, like our BASIC DNA assembly method, that transform our ability to rapidly prototype new biological designs. We are also developing enhanced methods for accurate metrology to better understand and model the relationship between input design and phenotypic response. These fundamental developments are being applied across a broad range of projects that address gene circuit design; RNA feedback control; in vivo directed evolution for the generation of new protein specificity and functionality; engineering protein nanocages as vectors for targeted drug delivery.

近期论文

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Webb AJ, Kelwick R, Doenhoff MJ, Kylilis N, MacDonald JT, Wen KY, McKeown C, Baldwin G, Ellis T, Jensen K, Freemont PSet al., 2016, A protease-based biosensor for the detection of schistosome cercariae, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Casini A, Storch M, Baldwin GS, Ellis Tet al., 2015, Bricks and blueprints: methods and standards for DNA assembly, NATURE REVIEWS MOLECULAR CELL BIOLOGY, Vol: 16, Pages: 568-576, ISSN: 1471-0072 Storch M, Casini A, Mackrow B, Fleming T, Trewhitt H, Ellis T, Baldwin GSet al., 2015, BASIC: A New Biopart Assembly Standard for Idempotent Cloning Provides Accurate, Single-Tier DNA Assembly for Synthetic Biology, ACS SYNTHETIC BIOLOGY, Vol: 4, Pages: 781-787, ISSN: 2161-5063 Casini A, Christodoulou G, Freemont PS, Baldwin GS, Ellis T, MacDonald JTet al., 2014, R2oDNA Designer: Computational Design of Biologically Neutral Synthetic DNA Sequences, ACS SYNTHETIC BIOLOGY, Vol: 3, Pages: 525-528, ISSN: 2161-5063 Casini A, MacDonald JT, De Jonghe J, Christodoulou G, Freemont PS, Baldwin GS, Ellis Tet al., 2014, One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy, NUCLEIC ACIDS RESEARCH, Vol: 42, ISSN: 0305-1048 Robinson T, Valluri P, Kennedy G, Sardini A, Dunsby C, Neil MAA, Baldwin GS, French PMW, de Mello AJet al., 2014, Analysis of DNA Binding and Nucleotide Flipping Kinetics Using Two-Color Two-Photon Fluorescence Lifetime Imaging Microscopy, ANALYTICAL CHEMISTRY, Vol: 86, Pages: 10732-10740, ISSN: 0003-2700 Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic Vet al., 2013, Specific DNA recognition mediated by a type IV pilin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 3065-3070, ISSN: 0027-8424 Lu D, Silhan J, MacDonald JT, Carpenter EP, Jensen K, Tang CM, Baldwin GS, Freemont PSet al., 2012, Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 16852-16857, ISSN: 0027-8424 Nagorska K, Silhan J, Li Y, Pelicic V, Freemont PS, Baldwin GS, Tang CMet al., 2012, A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis, MOLECULAR MICROBIOLOGY, Vol: 83, Pages: 1064-1079, ISSN: 0950-382X Silhan J, Nagorska K, Zhao Q, Jensen K, Freemont PS, Tang CM, Baldwin GSet al., 2012, Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis, NUCLEIC ACIDS RESEARCH, Vol: 40, Pages: 2065-2075, ISSN: 0305-1048 Ellis T, Adie T, Baldwin GS, 2011, DNA assembly for synthetic biology: from parts to pathways and beyond, INTEGRATIVE BIOLOGY, Vol: 3, Pages: 109-118, ISSN: 1757-9694 Grippon S, Zhao Q, Robinson T, Marshall JJT, O'Neill RJ, Manning H, Kennedy G, Dunsby C, Neil M, Halford SE, French PMW, Baldwin GSet al., 2011, Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway, NUCLEIC ACIDS RESEARCH, Vol: 39, Pages: 2593-2603, ISSN: 0305-1048 Ivanov AP, Instuli E, McGilvery CM, Baldwin G, McComb DW, Albrecht T, Edel JBet al., 2011, DNA Tunneling Detector Embedded in a Nanopore, NANO LETTERS, Vol: 11, Pages: 279-285, ISSN: 1530-6984 Sheppard C, Camara B, Shadrin A, Akulenko N, Lu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al., 2011, Inhibition of Escherichia coli RNAp by T7 Gp2 Protein: Role of Negatively Charged Strip of Amino Acid Residues in Gp2, JOURNAL OF MOLECULAR BIOLOGY, Vol: 407, Pages: 623-632, ISSN: 0022-2836 Ayub M, Ivanov A, Instuli E, Cecchini M, Chansin G, McGilvery C, Hong J, Baldwin G, McComb D, Edel JB, Albrecht Tet al., 2010, Nanopore/electrode structures for single-molecule biosensing, ELECTROCHIMICA ACTA, Vol: 55, Pages: 8237-8243, ISSN: 0013-4686 Robinson T, Manning HB, Dunsby C, Neil MAA, Baldwin GS, de Mello AJ, French PMWet al., 2010, Investigating fast enzyme-DNA kinetics using multidimensional fluorescence imaging and microfluidics, Conference on Microfluidics, BioMEMS, and Medical Microsystems VIII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X Baldwin GS, Brooks NJ, Robson RE, Wynveen A, Goldar A, Leikin S, Seddon JM, Kornyshev AAet al., 2009, DNA Double Helices Recognize Mutual Sequence Homology in a Protein Free Environment, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Vol: 26, Pages: 880-880, ISSN: 0739-1102 Robinson T, Schaerli Y, Wootton R, Hollfelder F, Dunsby C, Baldwin G, Neil M, French P, deMello Aet al., 2009, Removal of background signals from fluorescence thermometry measurements in PDMS microchannels using fluorescence lifetime imaging, LAB ON A CHIP, Vol: 9, Pages: 3437-3441, ISSN: 1473-0197 Baldwin GS, Brooks NJ, Robson RE, Wynveen A, Goldar A, Leikin S, Seddon JM, Kornyshev AAet al., 2008, DNA double helices recognize mutual sequence homology in a protein free environment, JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 112, Pages: 1060-1064, ISSN: 1520-6106 Briggs LC, Baldwin GS, Miyata N, Kondo H, Zhang X, Freemont PSet al., 2008, Analysis of nucleotide binding to p97 reveals the properties of a tandem AAA hexameric ATPase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 13745-13752, ISSN: 0021-9258