Xu, Xiao Yun - Imperial College London - Department of Chemical Engineering

个人简介

2011-2015 Director of Postgraduate Studies, Department of Chemical Engineering, Imperial College London 2009- Professor of Biofluid Mechanics, Department of Chemical Engineering, Imperial College London 2005-2009 Reader in Biofluid Mechanics, Department of Chemical Engineering, Imperial College London 2003-2005 Senior Lecturer, Department of Chemical Engineering, Imperial College London 1998-2003 Lecturer, Department of Chemical Engineering, Imperial College London 1992 PhD in Mechanical Engineering , City University, London, UK, Thesis Title: “Numerical Analysis of Blood Flow in 3-D Arterial Bifurcations” 1987 MSc in Thermo-Fluids Engineering , Dalian University of Technology, Dalian, China.

研究领域

My research interests include biomedical engineering and bioprocessing, with a special focus on transport processes in biological and physiological systems. My current research covers the following topics: image-based analysis of cardiovascular fluid mechanics and mass transport, multi-scale modelling of drug delivery to solid tumour, nanoparticle-mediated drug delivery in cancer and thrombolytic therapies, rheological behaviour of biomass suspensions and solid-liquid mixing in bioreactors for the production of fuels from energy crops.

近期论文

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Carallo C, Tripolino C, De Franceschi MS, Irace C, Xu XY, Gnasso Aet al., 2016, Carotid endothelial shear stress reduction with aging is associated with plaque development in twelve years, ATHEROSCLEROSIS, Vol: 251, Pages: 63-69, ISSN: 0021-9150 Cheng Z, Kidher E, Jarral OA, O'Regan DP, Wood NB, Athanasiou T, Xu XYet al., 2016, Assessment of Hemodynamic Conditions in the Aorta Following Root Replacement with Composite Valve-Conduit Graft, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 44, Pages: 1392-1404, ISSN: 0090-6964 Kandail H, Hamady M, Xu XY, 2016, Effect of a Flared Renal Stent on the Performance of Fenestrated Stent-Grafts at Rest and Exercise Conditions, JOURNAL OF ENDOVASCULAR THERAPY, Vol: 23, Pages: 809-820, ISSN: 1526-6028 Kandail HS, Hamady M, Xu XY, 2016, Hemodynamic Functions of Fenestrated Stent Graft under Resting, Hypertension, and Exercise Conditions., Front Surg, Vol: 3 Menichini C, Cheng Z, Gibbs RG, Xu XYet al., 2016, Predicting false lumen thrombosis in patient-specific models of aortic dissection., J R Soc Interface, Vol: 13 Menichini C, Xu XY, 2016, Mathematical modeling of thrombus formation in idealized models of aortic dissection: initial findings and potential applications, JOURNAL OF MATHEMATICAL BIOLOGY, Vol: 73, Pages: 1205-1226, ISSN: 0303-6812 Singh SD, Xu XY, Pepper JR, Izgi C, Treasure T, Mohiaddin RHet al., 2016, Effects of aortic root motion on wall stress in the Marfan aorta before and after personalised aortic root support (PEARS) surgery, JOURNAL OF BIOMECHANICS, Vol: 49, Pages: 2076-2084, ISSN: 0021-9290 Singh SD, Xu XY, Wood NB, Pepper JR, Izgi C, Treasure T, Mohiaddin RHet al., 2016, Aortic flow patterns before and after personalised external aortic root support implantation in Marfan patients, JOURNAL OF BIOMECHANICS, Vol: 49, Pages: 100-111, ISSN: 0021-9290 Su J, Huang C, Gu Z, Chen C, Xu Xet al., 2016, An Efficient RIGID Algorithm and Its Application to the Simulation of Particle Transport in Porous Medium, TRANSPORT IN POROUS MEDIA, Vol: 114, Pages: 99-131, ISSN: 0169-3913 Cheng Z, Wood NB, Gibbs RGJ, Xu XYet al., 2015, Geometric and Flow Features of Type B Aortic Dissection: Initial Findings and Comparison of Medically Treated and Stented Cases, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 43, Pages: 177-189, ISSN: 0090-6964 Kandail H, Hamady M, Xu XY, 2015, Comparison of blood flow in branched and fenestrated stent-grafts for endovascular repair of abdominal aortic aneurysms., Journal of Endovascular Therapy, Vol: 22, Pages: 578-590, ISSN: 1545-1550 Li Z-Y, Tan FPP, Soloperto G, Wood NB, Xu XY, Gillard JHet al., 2015, Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, Vol: 18, Pages: 1099-1107, ISSN: 1025-5842 Liu C, Krishnan J, Xu X-Y, 2015, Intrinsic and induced drug resistance mechanisms at the cellular and tissue scales, Integrative Biology, ISSN: 1757-9694 Liu C, Krishnan J, Xu XY, 2015, Intrinsic and induced drug resistance mechanisms: in silico investigations at the cellular and tissue scales, INTEGRATIVE BIOLOGY, Vol: 7, Pages: 1044-1060, ISSN: 1757-9694 Liu C, Xu XY, 2015, A systematic study of temperature sensitive liposomal delivery of doxorubicin using a mathematical model, Computers in Biology and Medicine, Vol: 60, Pages: 107-116, ISSN: 0010-4825 Malkawi A, Pirianov G, Torsney E, Chetter I, Sakalihasan N, Loftus IM, Nordon I, Huggins C, Charolidi N, Thompson M, Xu XY, Cockerill GWet al., 2015, Increased Expression of Lamin A/C Correlate with Regions of High Wall Stress in Abdominal Aortic Aneurysms., Aorta (Stamford), Vol: 3, Pages: 152-166 Piebalgs A, Xu XY, 2015, Towards a multi-physics modelling framework for thrombolysis under the influence of blood flow, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689 Singh SD, Xu XY, Pepper JR, Treasure T, Mohiaddin RHet al., 2015, Biomechanical properties of the Marfan's aortic root and ascending aorta before and after personalised external aortic root support surgery, MEDICAL ENGINEERING & PHYSICS, Vol: 37, Pages: 759-766, ISSN: 1350-4533 Su J, Gu Z, Chen C, Xu XYet al., 2015, A two-layer mesh method for discrete element simulation of gas-particle systems with arbitrarily polyhedral mesh, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Vol: 103, Pages: 759-780, ISSN: 0029-5981 Wang Z, Wood NB, Xu XY, 2015, A viscoelastic fluid-structure interaction model for carotid arteries under pulsatile flow, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, Vol: 31, ISSN: 2040-7939