Williams, Daryl - Imperial College London - Department of Chemical Engineering

个人简介

2012- Reader in Particle Science 2012- Director of Development -Discovery Space 2008-2011 Director of Pilot Plant Project 2003-2007 Director of External Relations 1994- EPSRC Advanced Fellow, Chemical Engineering Department, Imperial College London. 1991-1994 Research Fellow, Chemical Engineering Department, Imperial College London. 1986-1990 PhD Chemical Engineering Department, Imperial College London - Thesis Title " Interfacial Phenomena in Aramid Composites". 1983-1985 Experimental; Officer, MRL, Australia 1982-1983 MSc.(Polymer Science) Lehigh University, USA 1981-1982 Experimental, Officer, MRL, Australia 1977-1980 B.Sc.(Hons.) Physical Chemistry, University of Melbourne

研究领域

My current research interests focus on the particulate materials and material surfaces and their role in product manufacture including both biological and non-biological materials. I have developed a number of novel and leading edge methods for determining a range of surface and bulk physicochemical properties of powders and particulate materials including mechanical, topographical, chromatographic and surface properties. Recent studies have included studies of protein aggregation, protein crystallisation and freeze drying. The group has world leading expertise in gravimetric charactisation methods as well as inverse chromatographic methods, having pioneered many of these approaches. For example, the water sorption characterisation of many classes of materials, especially pharmaceuticals, biomataterials and biopharmaceutical is an area of significant interest. Current and new project areas include: Protein crystallisation using nanotemplates Surface energy mapping of complex organic powders Micromechanics of agglomerates and cellular entities Physical stability of bioformulations Second virial coefficents and protein-protein aggregation behaviour Freeze drying of therapeutics Surfaces and Particle Engineering Laboratory SMS - UK Surface Measurement Systems

近期论文

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Campbell KLS, Zhao Y, Hall JJ, Williams DRet al., 2016, The effect of CO2-loaded amine solvents on the corrosion of a carbon steel stripper, INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL, Vol: 47, Pages: 376-385, ISSN: 1750-5836 Hedberg SHM, Heng JYY, Williams DR, Liddell JMet al., 2016, Micro scale self-interaction chromatography of proteins: A mAb case-study, JOURNAL OF CHROMATOGRAPHY A, Vol: 1434, Pages: 57-63, ISSN: 0021-9673 Quigley A, Williams DR, 2016, Similar interaction chromatography of proteins: A cross interaction chromatographic approach to estimate the osmotic second virial coefficient, JOURNAL OF CHROMATOGRAPHY A, Vol: 1459, Pages: 47-56, ISSN: 0021-9673 Yu LCY, Campbell KLS, Williams DR, 2016, Using carbon steel in the stripper and reboiler for post-Combustion CO2 capture with aqueous amine blends, INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL, Vol: 51, Pages: 380-393, ISSN: 1750-5836 Campbell KLS, Lapidot T, Williams DR, 2015, Foaming of CO2-Loaded Amine Solvents Degraded Thermally under Stripper Conditions, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 54, Pages: 7751-7755, ISSN: 0888-5885 Cheung PCW, Williams DR, 2015, Separation of transition metals and chelated complexes in wastewaters, Environmental Progress & Sustainable Energy, Vol: 34, Pages: 761-783, ISSN: 1944-7442 Hedberg S, Heng JYY, Williams DR, Liddell Jet al., 2015, Chromatographic tools to predict the stability of mAbs for faster identification of therapeutic candidates, Pages: 1150-1151 Hedberg SHM, Heng JYY, Williams DR, Liddell JMet al., 2015, Self-Interaction Chromatography of mAbs: Accurate Measurement of Dead Volumes, PHARMACEUTICAL RESEARCH, Vol: 32, Pages: 3975-3985, ISSN: 0724-8741 Quigley A, Williams DR, 2015, The second virial coefficient as a predictor of protein aggregation propensity: A self-interaction chromatography study, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 96, Pages: 282-290, ISSN: 0939-6411 Shah UV, Parambil JV, Williams DR, Hinder SJ, Heng JYYet al., 2015, Preparation and characterisation of 3D nanotemplates for protein crystallisation, POWDER TECHNOLOGY, Vol: 282, Pages: 10-18, ISSN: 0032-5910 Williams DR, 2015, Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations, CURRENT PHARMACEUTICAL DESIGN, Vol: 21, Pages: 2677-2694, ISSN: 1381-6128 Devi S, Williams DR, 2014, Density dependent mechanical properties and structures of a freeze dried biopharmaceutical excipient - Sucrose, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 88, Pages: 492-501, ISSN: 0939-6411 Hedberg S, Quigley A, Heng JYY, Williams DR, Liddell Jet al., 2014, Self-interaction chromatography (SIC) of mabs: New methods for estimating the dead volume in SIC and using sic to predict mab stability, Pages: 897-907 Smith RR, Williams DR, Burnett DJ, Heng JYYet al., 2014, A New Method To Determine Dispersive Surface Energy Site Distributions by Inverse Gas Chromatography, LANGMUIR, Vol: 30, Pages: 8029-8035, ISSN: 0743-7463 Delmas T, Shah UV, Roberts MM, Williams DR, Heng JYYet al., 2013, Crystallisation of the orthorhombic form of acetaminophen: Combined effect of surface topography and chemistry, POWDER TECHNOLOGY, Vol: 236, Pages: 24-29, ISSN: 0032-5910 Devi S, Williams D, 2013, Morphological and Compressional Mechanical Properties of Freeze-Dried Mannitol, Sucrose, and Trehalose Cakes, JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 102, Pages: 4246-4255, ISSN: 0022-3549 Khoo JY, Shah UV, Schaepertoens M, Williams DR, Heng JYYet al., 2013, Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates, POWDER TECHNOLOGY, Vol: 236, Pages: 114-121, ISSN: 0032-5910 Quigley A, Heng JYY, Liddell JM, Williams DRet al., 2013, The accurate measurement of second virial coefficients using self-interaction chromatography: Experimental considerations, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Vol: 85, Pages: 1103-1111, ISSN: 0939-6411 Wang GD, Heng JYY, Williams DR, 2013, Dilatometry of powder compacts - Characterizing amorphous-crystalline transformations, POWDER TECHNOLOGY, Vol: 236, Pages: 12-16, ISSN: 0032-5910 Ho R, Naderi M, Heng JYY, Williams DR, Thielmann F, Bouza P, Keith AR, Thiele G, Burnett DJet al., 2012, Effect of Milling on Particle Shape and Surface Energy Heterogeneity of Needle-Shaped Crystals, PHARMACEUTICAL RESEARCH, Vol: 29, Pages: 2806-2816, ISSN: 0724-8741