Xiong, Yue - The University of North Carolina at Chapel Hill - Department of Biochemistry and Biophysics

研究领域

The major goal of the laboratory is to combine genetics, cellular, biochemical and proteomic approaches to determine the mechanisms controlling the cell cycle in normal human cells, in both stem and somatic cells, and how this control is altered during tumorigenesis. Three major areas of our current research are: 1) Cancer and stem cell cycle control by CDK inhibitors 2) Control of p53 ubiquitylation and 3) Cullin-Ring family E3 ubiquitin ligases.

近期论文

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Han, X.-R., Sasaki, N. Jackson, S.C., Wang, P. Li, Z. Smith, M.D., Xie, L., Chen, X., Zhang, Y., Marzluff, W.F., Xiong, Y. (2020) CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. Science Advances, Vol. 6, no. 51. Chen, L-L. Smith, M.D., Lv, L., Nakagawa, T. Li, Z. Sun, S-C., Brown, N.G., Xiong, Y., Xu, Y-P. (2020) USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. Science Advances, Vol. 6, no. 38. Cheng, M., Yu, X., Lu, K., Xie, L., Wang, L., Meng, F., Han, X., Chen, X., Liu, J., Xiong, Y., Jin, J. (2020) Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-molecule Degraders. J Med Chem.n doi: 10.1021/acs.jmedchem.9b01566 Wang, P., Yan, F., Li, Z., Yu, Y., Parnell, S.E., Xiong, Y. (2019) Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Journal of Clinical Investigation doi: 10.1172/JCI129107 Xu, Y-P., Lv, L., Liu, Y., Smith, M.D., Li, W-C., Tan, X-M., Cheng, M., Li, Z., Bovino, M., Aubé, J., Xiong, Y. (2019) Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. Journal of Clinical Investigation 130. pii: 129317. doi: 10.1172/JCI129317 Lv, L., Wang, Q., Xu, Y-P., Tsao, L-C., Nakagawa, T., Guo, H-T., Su, L-S., and Xiong, Y. (2018) Vpr targets TET2 for degradation by CRL4VprBP E3 ligase to sustain IL-6 expression and enhance HIV-1 replication. Mol Cell. 70(5):961-970. Zhang, C., Han, X.-R., Yang, X., Jiang, B., Liu, J., Xiong, Y., Jin, J. (2018) Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). Eur J Med Chem. 151:304-314. Liu, M.X., Jin, L., Sun, S.J., Liu, P., Feng, X., Cheng Z.L., Liu, W.R., Guan, K.-L., Shi, Y.H. Yuan H.X., Xiong Y. (2018) Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 37(12):1637-1653. Li, Z. and Xiong, Y. (2017) Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene 36(36):5212-5218. Lin, R., Mo, Y., Zha, H-H., Qu, Z-P., Xie, P-C., Zhu, Z-J., Xu, Y., Xiong, Y., and Guan, K-L. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell 68:198-209 Lin, H.P., Cheng, Z.L., He, R.Y., Song, L., Tian, M.X., Zhou, L.S., Groh, B.S., Liu, W.R., Ji, M.B., Ding, C., Shi, Y.H., Guan, K.L., Ye, D., Xiong, Y. (2016) Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Research 76(23):6924-6936. Lyons, S.M., Cunningham, C.H., Welch, J.D., Groh, B., Guo, A.Y., Wei, B., Whitfield. M.L., Xiong, Y,, Marzluff, W.F. (2016) A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues. Nucleic Acids Res. 44(19):9190-9205. Murphy, C.M., Xu, Y., Li, F., Nio, K., Reszka-Blanco, N., Li, X., Wu, Y., Yu, Y., Xiong, Y., Su, L. (2016) Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication. Cell Rep. 16(11):2846-54. Groh, B.S., Yan F., Smith, M.D., Yu, Y., Chen, X., Xiong, Y. (2016) The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. EMBO Rep 17(5):638-47. Han, X-R., Zha, Z-Y., Yuan, H-X., Feng, X., Xia, Y-K., Lei, Q-Y., Guan, K-G. and Xiong, Y. (2016) KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene 35(32):4179-90. Wang, P., Wu, J., Ma, S-H., Yao, J., Hoadley, K. A., Wilkerson, M. D., Perou, C. M., Guan, K-G., Ye, D. and Xiong, Y. (2015) Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH-mutated cells to alkylating agents. Cell Rep 13:2353-2361. Zha, Z., Han, X., Smith, M.D., Liu, Y., Giguère, P.M., Kopanja, D., Raychaudhuri, P., Siderovski, D.P., Guan, K-L., Lei, Q.Y., and Xiong, Y. (2015) A Non-Canonical Function of Gß as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Molecular Cell 58(5):794-803. Yang, H., Zhou, L., Shi, Q., Zhao, Y., Lin, H., Zhang, M., Zhao, S., Yang, Y., Ling, Z.Q., Guan, K-L., Xiong, Y., and Ye, D. (2015) SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J 34(8):1110-25. Wang, Y., Xiao, M., Chen, X., Chen, L., Xu, Y., Lv, L., Wang, P., Yang, H., Ma, S., Lin, H., Jiao, B., Ren, R., Ye, D., Guan, K-L., and Xiong, Y. (2015) WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Molecular Cell 57(4):662-73. Nakagawa, T., Lv, L., Nakagawa, M., Yu, Y., Yu, C., D’Alessio, A.C., Nakayama, K., Fan, H.Y., Chen, X., and Xiong, Y. (2015) CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Molecular Cell 57(2):247-60.