Gu, Zi - University of New South Wales - School of Chemical Engineering

个人简介

Dr Zi (Sophia) Gu is a Senior Lecturer, Principle Investigator, and Head of NanoBiotechnology Research Laboratory at School of Chemical Engineering of UNSW. After PhD training at The University of Queensland and Cornell University (US), she was engaged in a commercialisation project of drug-delivered nanotechnologies which led to 5 successful Clinical Trials. She was awarded a NHMRC Peter Doherty Biomedical Early Career Fellowship in 2014, prior to joining UNSW in 2016. She was promoted to Senior Lecturer in 2019. Currently, she leads a NanoBiotechnology Research Group working on multidisciplinary research projects that combine the knowledge and skills across material chemistry, biomedical engineering and nanotechnology, and developed several nanoparticle platforms for disease diagnosis and treatment. She has published >60 research papers and filed a provisional patent. Most of these publications are in top tier journals in the fields of Material Science (Advanced Materials, Advanced Functional Materials, Materials Horizons), Nanotechnology (Advanced Science, Small, Small Methods), Chemistry (Chemistry of Materials), Biomaterials (Biomaterials), and Pharmaceutical Science (Journal of Controlled Release, Pharmaceutics). She has been awarded several grants and awards and has several academic leadership roles such as international conference chair, and an Associate Editor for Journal of Nanobiotechnology (Springer Nature).

研究领域

Nanotechnology has emerged as a promising approach for precision diagnosis and treatment of life-threatening diseases. Towards the aim of developing safe and efficacious nanoparticle systems, my group utilises interdisciplinary approaches that bring together material chemistry, biomedical engineering and nanotechnology to synthesise functional nanoparticles, optimise their biomedical properties, and develope smart nanoparticles and advanced delivery strategies. There are three major interests of our research: Research interest 1: Targeted, controlled and selective drug delivery system. Developing advanced drug delivery systems where nanoparticles are able to target the specific biological site, and function as both drug carriers and drug precursors, which not only transport the loaded drug molecules to the targeted biological site, but also ensure that the nanoparticles do not damage normal tissues until reaching the target, thereby minimizing the toxicity to normal tissues and maximizing the therapeutic efficacy. Research interest 2: Bioimaging probe/contrast agent design. Developing smart nanoparticles to detect and monitor pathological processes in the disease environment. Research interest 3: Multifunctional bioactive nanoparticles. Developing inorganic nanoparticles with multiple and state-of-the-art therapeutic and diagnostic modalities.

近期论文

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Liu R; Yang C; Huang Z; French R; Gu Z; Cheng J; Guo K; Xu J, 2022, 'Unraveling Sequence Effect on Glass Transition Temperatures of Discrete Unconjugated Oligomers', Macromolecular Rapid Communications, vol. 43, Yao C; Qi H; Jia X; Xu Y; Tong Z; Gu Z; Yang D, 2022, 'A DNA Nanocomplex Containing Cascade DNAzymes and Promoter-Like Zn-Mn-Ferrite for Combined Gene/Chemo-dynamic Therapy', Angewandte Chemie - International Edition, vol. 61, Zhang Q; Zhou D; Fang G; Lu H; Zeng J; Gu Z, 2022, 'Cell-Derived Biomimetic 2D Nanoparticles to Improve Cell-Specific Targeting and Tissue Penetration for Enhanced Magnetic Resonance Imaging', Advanced Materials Interfaces, vol. 9, Zhang H; Zhang Q; Guo Z; Liang K; Boyer C; Liu J; Zheng Z; Amal R; Yun SLJ; Gu Z, 2022, 'Disulfiram-loaded metal organic framework for precision cancer treatment via ultrasensitive tumor microenvironment-responsive copper chelation and radical generation', Journal of Colloid and Interface Science, vol. 615, pp. 517 - 526, Wang X; Yan M; Zhou J; Song W; Xiao Y; Cui C; Gao W; Ke F; Zhu J; Gu Z; Hou R, 2021, 'Delivery of acetamiprid to tea leaves enabled by porous silica nanoparticles: efficiency, distribution and metabolism of acetamiprid in tea plants', BMC Plant Biology, vol. 21, Wang X; Hu C; Gu Z; Dai L, 2021, 'Understanding of catalytic ROS generation from defect-rich graphene quantum-dots for therapeutic effects in tumor microenvironment', Journal of Nanobiotechnology, vol. 19, pp. 340, Han J; Cui Y; Gu Z; Yang D, 2021, 'Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells', Biomaterials, vol. 273, pp. 120846, Li F; Yu W; Zhang J; Dong Y; Ding X; Ruan X; Gu Z; Yang D, 2021, 'Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery', Nature Communications, vol. 12, pp. 1138, Han J; Cui Y; Li F; Gu Z; Yang D, 2021, 'Responsive disassembly of nucleic acid nanocomplex in cells for precision medicine', Nano Today, vol. 39, Guo Z; Xie W; Lu J; Guo X; Chi Y; Wang D; Takuya N; Xu W; Ye J; Liu X; Gu Z; Xu B; Wu H; Zhao L, 2021, 'Ferrous ions doped layered double hydroxide: Smart 2D nanotheranostic platform with imaging-guided synergistic chemo/photothermal therapy for breast cancer', Biomaterials Science, vol. 9, pp. 5928 - 5938, Peguda HK; Mahbub SB; Sherpa TD; Subedi D; Habibalahi A; Anwer AG; Gu Z; Willcox MDP; Goldys EM; Carnt NA, 2021, 'The autofluorescence patterns of acanthamoeba castellanii, pseudomonas aeruginosa and staphylococcus aureus: Effects of antibiotics and tetracaine', Pathogens, vol. 10, Zhao H; Li T; Yao C; Gu Z; Liu C; Li J; Yang D, 2021, 'Dual Roles of Metal-Organic Frameworks as Nanocarriers for miRNA Delivery and Adjuvants for Chemodynamic Therapy', ACS Applied Materials and Interfaces, vol. 13, pp. 6034 - 6042, Zhao H; Lv J; Li F; Zhang Z; Zhang C; Gu Z; Yang D, 2021, 'Enzymatical biomineralization of DNA nanoflowers mediated by manganese ions for tumor site activated magnetic resonance imaging', Biomaterials, vol. 268, Cao Z; Zhang L; Liu J; Wang D; Liang K; Chen Y; Gu Z, 2021, 'A dual enzyme-mimicking radical generator for enhanced photodynamic therapy: Via series-parallel catalysis', Nanoscale, vol. 13, pp. 17386 - 17395, Guo Z; Liu J; Li Y; McDonald JA; Bin Zulkifli MY; Khan SJ; Xie L; Gu Z; Kong B; Liang K, 2020, 'Biocatalytic metal-organic framework nanomotors for active water decontamination', Chemical Communications, vol. 56, pp. 14837 - 14840, Zhang Q; Liang J; Yun SLJ; Liang K; Yang D; Gu Z, 2020, 'Recent advances in improving tumor-targeted delivery of imaging nanoprobes', Biomaterials Science, vol. 8, pp. 4108 - 4125, Guo X; Li F; Liu C; Zhu Y; Xiao N; Gu Z; Luo D; Jiang J; Yang D, 2020, 'Construction of Organelle-Like Architecture by Dynamic DNA Assembly in Living Cells', Angewandte Chemie - International Edition, vol. 59, pp. 20651 - 20658, Li B; Hao G; Sun B; Gu Z; Xu ZP, 2020, 'Engineering a Therapy-Induced “Immunogenic Cancer Cell Death” Amplifier to Boost Systemic Tumor Elimination', Advanced Functional Materials, vol. 30, Cao Z; Li B; Sun L; Li L; Xu ZP; Gu Z, 2020, '2D Layered Double Hydroxide Nanoparticles: Recent Progress toward Preclinical/Clinical Nanomedicine', Small Methods, vol. 4, Zhang H; Cao Z; Zhang Q; Xu J; Yun SLJ; Liang K; Gu Z, 2020, 'Chemotaxis-Driven 2D Nanosheet for Directional Drug Delivery toward the Tumor Microenvironment', Small, vol. 16, pp. e2002732,