Sevov, Christo - The Ohio State University - Department of Chemistry & Biochemistry

个人简介

Christo was born in Sofia, Bulgaria and moved to the US at the age of four. He spent his formative years in South Bend, IN and received his B.S. in 2009 from the University of Notre Dame. There, Christo worked with Prof. Olaf Wiest on photocatalyzed cycloaddition reactions with selectivities that complement those of traditional Diels-Alder processes. Christo earned his Ph.D. in 2014 after beginning his studies at the University of Illinois Urbana-Champaign with Prof. John Hartwig and later moving with the group to the University of California Berkeley. His research involved the development of methods and mechanistic study of metal-catalyzed additions of C–H, N–H, and O–H bonds across alkenes. Following his doctoral studies, Christo conducted his postdoctoral work with Prof. Melanie Sanford at the University of Michigan. Applying an organic chemist’s approach to energy storage, Christo designed new organic and organometallic compounds that could serve as redox liquids for large-scale flow batteries. Christo joined the faculty of The Ohio State University in the summer of 2017 as an assistant professor in the Department of Chemistry and Biochemistry where he is merging his love of catalysis and electrochemistry for both synthesis and energy storage.

研究领域

The Sevov lab develops strategies at the interface of homogeneous catalysis and electrochemistry for the sustainable utilization of electricity that is generated from renewable sources. By treating electrical energy as a reagent, our group aims to demonstrate that toxic, explosive, or expensive reagents, which drive traditional synthetic organic processes, can be replaced with inexpensive and benign additives. This will enable organic synthesis to be performed in a safe, sustainable, and scalable manner. In addition to the application of electrical energy to synthesis, we seek to design large scale energy storage systems that can assist with the integration of intermittent electrical loads from renewable sources into the electrical grid. Sevov lab members addressing these challenges will be trained and exposed to the multidisciplinary fields of organic and organometallic synthesis, catalyst design, mechanistic study, materials development, and electroanalytical evaluation. Electrically-Driven Homogeneous Catalysis The development of metal-catalyzed reactions has revolutionized synthetic organic chemistry. Because many of these catalytic processes necessitate changes to the oxidation state of the metal, catalysts are generally of noble metals with vetted ligands that facilitate the redox events. To render these transformations favorable, high energy additives are added or substrates are prefunctionalized. Our lab is interested in utilizing electrochemistry in combination with homogeneous catalysis to drive chemical reactions by modulating the input of electrical energy, which allows electrons to be treated like inexpensive reagents. In doing so, our lab will develop methods for complex organic synthesis that (i) utilize earth-abundant metal catalysts, (ii) convert stoichiometric reagents into catalysts, and (iii) access high-energy intermediates under mild conditions to accelerate turnover-limiting processes. Large-Scale Energy Storage Integration of electrical energy that is harnessed by wind turbines or photovoltaics into the electrical grid requires large-scale energy storage systems that can modulate the variable and intermittent nature of these energy sources. However, the immense scale of this challenge precludes the use of most established battery technologies due to their cost. Our group will pursue an interdisciplinary approach of organic synthesis, polymers and materials development, and electroanalytical chemistry to invent scalable energy storage devices that utilize inexpensive liquid anode and cathode materials for shuttling and storing energy.

近期论文

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Controlling Ni Redox States by Dynamic Ligand Exchange for Electroreductive Csp3-Csp2 Coupling. Hamby, T. B.; LaLama, M. J.; Sevov, C. S., Science, 2022, 376, 410. Catalyst-Controlled Functionalization of Carboxylic Acids by Electrooxidation of Self-Assembled Carboxyl Monolayers. Hintz, H. A.; Sevov, C. S., Nature Commun. 2022, 13, 1319. Synergistic Catalyst–Mediator Pairings for Electroreductive Cross-Electrophile Coupling Reactions. Zackasee, J. L. S.; Al Zubaydi, S.; Truesdell, B. L.; Sevov, C. S., ACS Catal. 2022, 12, 1161. Mediator-Enabled Electrocatalysis with Ligandless Copper for Anaerobic Chan-Lam Coupling Reactions. Walker, B. R.; Manabe, S.; Brusoe, A. T.; Sevov, C. S., J. Am. Chem. Soc. 2021, 143, 6257. All-Organic Storage Solids and Redox Shuttles for Redox-Targeting Flow Batteries. Wong, C. M.; Sevov, C. S., ACS Energy Lett. 2021, 6, 1271. General C(sp2)-C(sp3) Cross-Electrophile Coupling Reactions Enabled by Overcharge Protection of Homogeneous Electrocatalysts. Truesdell, B. L.; Hamby, T. B.; Sevov, C. S., J. Am. Chem. Soc. 2020, 142, 5884. Direct and Scalable Electroreduction of Triphenylphosphine Oxide to Triphenylphosphine. Manabe, S.; Wong, C. M.; Sevov, C. S., J. Am. Chem. Soc. 2020, 142, 3024. An Electrochemically-Promoted, Nickel-Catalyzed, Mizoroki-Heck Reaction. Walker, B. R.; Sevov, C. S., ACS Catal. 2019, 9, 7197. Effect of the Backbone Tether on the Electrochemical Properties of Soluble Cyclopropenium Redox-Active Polymers. Montoto, E. C.; Cao, Y.; Hernández-Burgos, K.; Sevov, C. S.; Braten, M. N.; Helms, B. A.; Moore, J. S.; Rodríguez-López, J., Macromolecules 2018, 10, 3539. High-Performance Oligomeric Catholytes for Effective Macromolecular Separation in Nonaqueous Redox Flow Batteries. Hendriks, K. H.; Robinson, S. G.; Braten, M. N.; Sevov, C. S.; Helms, B. A.; Sigman, M. S.; Minteer, S. D.; Sanford, M. S. ACS Cent. Sci. 2018, 4, 189. Low-Potential Pyridinium Anolyte for Aqueous Redox Flow Batteries. Sevov, C. S.; Hendriks, K. H.; Sanford, M. S. J. Phys. Chem. C 2017, 121, 24376. Multielectron Cycling of a Low-Potential Anolyte in Alkali Metal Electrolytes for Nonaqueous Redox Flow Batteries. ‡Hendriks, K. H.; ‡Sevov, C. S.; Cook, M. E.; Sanford, M. S. ACS Energy Lett. 2017, 2, 2430. (‡Equal Contribution) Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications. Sevov, C. S.; Hickey, D. P.; Cook, M. E.; Robinson, S. G.; Barnett, S.; Minteer, S. D.; Sigman, M. S.; Sanford, M. S. J. Am. Chem. Soc. 2017, 139, 2924. Macromolecular Design Strategies for Preventing Active-Material Crossover in Non-Aqueous All-Organic Redox-Flow Batteries. Doris, S. E.; Ward, A. L.; Baskin, A.; Frischmann, P. D.; Gavvalapalli, N.; Chénard, E.; Sevov, C. S.; Prendergast, D.; Moore, J. S.; Helms, B. A. Angew. Chem. Int. Ed. 2017, 56, 1595. Cyclopropenium Salts as Cyclable, High-Potential Catholytes in Nonaqueous Media. Sevov, C. S.; Samaroo, S. K.; Sanford, M. S. Adv. Energy Mater. 2016, 1602027. Mechanism-Based Development of a Low-Potential, Soluble, and Cyclable Multielectron Anolyte for Nonaqueous Redox Flow Batteries. ‡Sevov, C. S.; ‡Fisher, S. L.; Thompson, L. T.; Sanford, M. S. J Am Chem Soc 2016, 138, 15378. (‡Equal Contribution) Evolutionary Design of Low Molecular Weight Organic Anolyte Materials for Applications in Nonaqueous Redox Flow Batteries. Sevov, C. S.; Brooner, R. E. M.; Chénard, E.; Assary, R. S.; Moore, J. S.; Rodríguez-López, J.; Sanford, M. S. J. Am. Chem. Soc. 2015, 137, 14465. Iridium-Catalyzed Oxidative Olefination of Furans with Unactivated Alkenes. Sevov, C. S.; Hartwig, J. F. J. Am. Chem. Soc. 2014, 136, 10625. Iridium-Catalyzed, Intermolecular Hydroamination of Unactivated Alkenes with Indoles. Sevov, C. S.; Zhou, J.; Hartwig, J. F. J. Am. Chem. Soc. 2014, 136, 3200. Iridium-Catalyzed, Intermolecular Hydroetherification of Unactivated Aliphatic Alkenes with Phenols. Sevov, C. S.; Hartwig, J. F. J. Am. Chem. Soc. 2013, 135, 9303. Iridium-Catalyzed Intermolecular Asymmetric Hydroheteroarylation of Bicycloalkenes. Sevov, C. S.; Hartwig, J. F. J. Am. Chem. Soc. 2013, 135, 2116.