Krishnan, - Imperial College London - Department of Chemical Engineering

个人简介

2006- Lecturer, Senior Lecturer in Chemical Engineering, Imperial College London 2001-2005 Associate Research Scientist, Dept. of Electrical Engineering, Johns Hopkins University 1994-2000 PhD, Chemical Engineering, Princeton University. Thesis Title: Patterns and their instabilities in CO oxidation on Pt(110). 1990-1994 B.Tech, Chemical Engineering, Indian Institute of Technology, Madras (Chennai).

研究领域

The unifying theme of the research in my group is the elucidation and manipulation of information processing in cells and tissues. This is achieved through a combination of (i) Mathematical modelling (ii) Theoretical work (iii) Systems approaches, including tool development and (iv) Collaboration with a range of experimentalists including cell biologists, biomedical scientists and engineers and synthetic biologists. Characteristic of this research area is the diversity of problems at different levels and scales, the broad potential for application and the rich confluence of the natural sciences (biology, physics, chemistry), mathematics and engineering, including systems engineering. There are also non-biological analogues and extensions of this work. This is discussed briefly below and in more detail in the research page. The regulation of most aspects of cellular life and functioning is accomplished by complex and sophisticated biochemical (signal transduction,metabolic) and gene regulatory networks. Understanding the functioning of and information processing through such networks at both the intracellular level as well as the intercellular level (accounting for cellular communication and interaction) is of importance from both basic and applied perspectives. This is because information processing through these networks is the key ingredient which allows us to understand how cells regulate different processes, respond to their environment, interact with one another and affords ways of controlling or manipulating them through synthetic and other means. The research in my group employs an interdisciplinary engineering approach in this context, and has two broad strands. (i) Mathematical and computational modelling in a selection of concrete problems of basic and applied interest, in collaboration with a range of experimentalists (cell biologists, biomedical scientists and engineers, synthetic biologists). (ii) Theoretical and systems work, including tool development towards the elucidation and systematic manipulation of information processing in cells and tissues.The research of each strand informs the other, and employing both approaches allows for a synergistic interplay between the two.

近期论文

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Menon G, Krishnan J, 2016, Bridging the gap between modules in isolation and as part of networks: A systems framework for elucidating interaction and regulation of signalling modules, JOURNAL OF CHEMICAL PHYSICS, Vol: 145, ISSN: 0021-9606 Seaton DD, Krishnan J, 2016, Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments, PLOS COMPUTATIONAL BIOLOGY, Vol: 12, ISSN: 1553-734X Zhao Y-B, Krishnan J, 2016, Probabilistic Boolean Network Modelling and Analysis Framework for mRNA Translation, IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, Vol: 13, Pages: 754-766, ISSN: 1545-5963 Alam-Nazki A, Krishnan J, 2015, Spatial Control of Biochemical Modification Cascades and Pathways, BIOPHYSICAL JOURNAL, Vol: 108, Pages: 2912-2924, ISSN: 0006-3495 Liu C, Krishnan J, Xu X-Y, 2015, Intrinsic and induced drug resistance mechanisms at the cellular and tissue scales, Integrative Biology, ISSN: 1757-9694 Liu C, Krishnan J, Xu XY, 2015, Intrinsic and induced drug resistance mechanisms: in silico investigations at the cellular and tissue scales, INTEGRATIVE BIOLOGY, Vol: 7, Pages: 1044-1060, ISSN: 1757-9694 Suwanmajo T, Krishnan J, 2015, Mixed mechanisms of multi-site phosphorylation, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689 Krishnan J, Liu C, 2014, An investigation of signal transduction and irreversible decision making through monostable and bistable switches, A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems, Pages: 219-243, ISBN: 9789401790475 Krishnan J, Mois K, Suwanmajo T, 2014, The behaviour of basic autocatalytic signalling modules in isolation and embedded in networks, JOURNAL OF CHEMICAL PHYSICS, Vol: 141, ISSN: 0021-9606 Liu C, Krishnan, Xu XY, 2014, Towards an integrated systems-based modelling framework for drug transport and its effect on tumour cells, JOURNAL OF BIOLOGICAL ENGINEERING, Vol: 8, ISSN: 1754-1611 Zhao Y-B, Krishnan J, 2014, mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach, BMC SYSTEMS BIOLOGY, Vol: 8, ISSN: 1752-0509 Alam-Nazki A, Krishnan J, 2013, Covalent Modification Cycles through the Spatial Prism, BIOPHYSICAL JOURNAL, Vol: 105, Pages: 1720-1731, ISSN: 0006-3495 Krishnan J, Alam-Nazki A, 2013, Elucidating design principles underlying attractive and repulsive gradient sensing in eukaryotic chemotaxis Liu C, Krishnan J, Xu XY, 2013, Investigating the effects of ABC transporter-based acquired drug resistance mechanisms at the cellular and tissue scale, INTEGRATIVE BIOLOGY, Vol: 5, Pages: 555-568, ISSN: 1757-9694 Suwanmajo T, Krishnan J, 2013, Biphasic responses in multi-site phosphorylation systems, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 10, ISSN: 1742-5689 Alam-Nazki A, Krishnan J, 2012, An investigation of spatial signal transduction in cellular networks, BMC SYSTEMS BIOLOGY, Vol: 6, ISSN: 1752-0509 Betney R, de Silva E, Mertens C, Knox Y, Krishnan J, Stansfield Iet al., 2012, Regulation of release factor expression using a translational negative feedback loop: A systems analysis, RNA-A PUBLICATION OF THE RNA SOCIETY, Vol: 18, Pages: 2320-2334, ISSN: 1355-8382 Liu C, Krishnan J, Xu XY, 2012, Investigation of the effect of drugs on solid tumours within a systems-based mathematical modelling framework, Pages: 131-135 Seaton DD, Krishnan J, 2012, Multispecific interactions in enzymatic signalling cascades, Pages: 67-73, ISSN: 0302-9743 Seaton DD, Krishnan J, 2012, Effects of multiple enzyme-substrate interactions in basic units of cellular signal processing, PHYSICAL BIOLOGY, Vol: 9, ISSN: 1478-3967