Kontoravdi, Cleo - Imperial College London - Department of Chemical Engineering

个人简介

2007- Lecturer in Chemical Engineering (Lonza/RCUK Academic Fellowship) 2006-2007 Research and Development Scientist, Lonza Biologics 2007 PhD in Chemical Engineering, Imperial College London. An Integrated Modelling/Experimental Framework for Protein-producing Animal Cell Cultures. 2002 MEng in Chemical Engineering, Imperial College London

研究领域

My interests lie in the area of biotechnology, with particular focus on the application of systems engineering principles to bioprocessing. My research involves the systematic integration of model-based tools, such as sensitivity analysis, design of experiments and optimisation, with experimentation on mammalian cell culture systems. Topics of interest include optimisation of culture media and conditions productivity, protein glycosylation, metabolic flux analysis and multiscale modelling.

近期论文

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Klymenko OV, Shah N, Kontoravdi C, Royle KE, Polizzi KMet al., 2016, Designing an Artificial Golgi Reactor to Achieve Targeted Glycosylation of Monoclonal Antibodies, AICHE JOURNAL, Vol: 62, Pages: 2959-2973, ISSN: 0001-1541 Niu H, Shah N, Kontoravdi C, 2016, Modelling of amorphous cellulose depolymerisation by cellulases, parametric studies and optimisation, BIOCHEMICAL ENGINEERING JOURNAL, Vol: 105, Pages: 455-472, ISSN: 1369-703X del Val IJ, Polizzi KM, Kontoravdi C, 2016, A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Fan Y, Del Val IJ, Mueller C, Sen JW, Rasmussen SK, Kontoravdi C, Weilguny D, Andersen MRet al., 2015, Amino Acid and Glucose Metabolism in Fed-Batch CHO Cell Culture Affects Antibody Production and Glycosylation, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 112, Pages: 521-535, ISSN: 0006-3592 Fan Y, Del Val IJ, Muller C, Lund AM, Sen JW, Rasmussen SK, Kontoravdi C, Baycin-Hizal D, Betenbaugh MJ, Weilguny D, Andersen MRet al., 2015, A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 112, Pages: 2172-2184, ISSN: 0006-3592 Niv H, Leak D, Shah N, Kontoravdi Cet al., 2015, Metabolic characterization and modeling of fermentation process of an engineered Geobacillus thermoglucosidasius strain for bioethanol production with gas stripping, CHEMICAL ENGINEERING SCIENCE, Vol: 122, Pages: 138-149, ISSN: 0009-2509 Oliveira PH, Mairhofer J, Alves PM, Lara AR, Kontoravdi Cet al., 2015, Advances in the Development of Biotherapeutics, BioMed Research International, Vol: 2015, ISSN: 2314-6133 Polizzi KM, Kontoravdi C, 2015, Genetically-encoded biosensors for monitoring cellular stress in bioprocessing, CURRENT OPINION IN BIOTECHNOLOGY, Vol: 31, Pages: 50-56, ISSN: 0958-1669 Sou SN, Sellick C, Lee K, Mason A, Kyriakopoulos S, Polizzi KM, Kontoravdi Cet al., 2015, How does mild hypothermia affect monoclonal antibody glycosylation?, Biotechnology and Bioengineering, Vol: 112, Pages: 1165-1176, ISSN: 1097-0290 Behjousiar A, Constantinou A, Polizzi KM, Kontoravdi Cet al., 2014, FIBS-enabled Noninvasive Metabolic Profiling, Jove-Journal of Visualized Experiments, ISSN: 1940-087X Jedrzejewski PM, del Val IJ, Constantinou A, Dell A, Haslam SM, Polizzi KM, Kontoravdi Cet al., 2014, Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 15, Pages: 4492-4522, ISSN: 1422-0067 Kyriakopoulos S, Kontoravdi C, 2014, A Framework for the Systematic Design of Fed-Batch Strategies in Mammalian Cell Culture, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 111, Pages: 2466-2476, ISSN: 0006-3592 Kyriakopoulos S, Kontoravdi C, 2014, Insights on biomarkers from Chinese hamster ovary ‘omics’ studies, Pharmaceutical Bioprocessing, Vol: 2, Pages: 389-401, ISSN: 2048-9145 Todri E, Amenaghawon AN, del Val IJ, Leak DJ, Kontoravdi C, Kucherenko S, Shah Net al., 2014, Global sensitivity analysis and meta-modeling of an ethanol production process, CHEMICAL ENGINEERING SCIENCE, Vol: 114, Pages: 114-127, ISSN: 0009-2509 Chen N, Bennett MH, Kontoravdi C, 2013, Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach, Cytotechnology, Vol: Online First Jedrzejewski PM, Jimenez del Val I, Polizzi KM, Kontoravdi Cet al., 2013, Applying quality by design to glycoprotein therapeutics: experimental and computational efforts of process control, Pharmaceutical Bioprocessing, Vol: 1, Pages: 51-69 Jimenez Del Val I, Constantinou A, Dell A, Haslam S, Jedrzejewski P, Polizzi KM, Kontoravdi Cet al., 2013, An integrated mechanistic model for nucleotide sugar metabolism and monoclonal antibody glycosylation, Pages: 658-659 Jimenez del Val I, Constantinou A, Dell A, Haslam S, Polizzi KM, Kontoravdi Cet al., 2013, A quantitative and mechanistic model for monoclonal antibody glycosylation as a function of nutrient availability during cell culture, 23rd European Society for Animal Cell Technology (ESACT) Meeting: Better Cells for Better Health Kontoravdi C, 2013, Systematic methodology for the development of mathematical models for biological processes., Methods Mol Biol, Vol: 1073, Pages: 177-190 Kontoravdi C, Samsatli NJ, Shah N, 2013, Development and design of bio-pharmaceutical processes, CURRENT OPINION IN CHEMICAL ENGINEERING, Vol: 2, Pages: 435-441, ISSN: 2211-3398