DiMaggio, Peter - Imperial College London - Department of Chemical Engineering

个人简介

2015- Senior Lecturer, Department of Chemical Engineering, Imperial College London 2012-2015 Lecturer, Department of Chemical Engineering, Imperial College London 2010-2012 NIH/NRSA Postdoctoral Fellow, Department of Molecular Biology, Princeton University 2004-2010 PhD in Chemical Engineering, Department of Chemical Engineering, Princeton University

研究领域

The DiMaggio Lab is interested in the development and application of innovative experimental and computational platforms for characterizing chromatin-associated proteins and how their interactions and post-translational modifications cooperatively regulate nuclear processes, such as gene expression. At the center of our research program is liquid chromatography tandem mass spectrometry (LC-MS/MS), and our work contributes to this field on two fronts: 1. The application of fundamental chemical engineering principles towards the design, modeling and optimization of separation processes and analyte detection. 2. The development of optimization-based computational tools for robustly interpretting novel sources of LC-MS/MS data.

近期论文

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Chen PB, Ding S, Zanghi G, Soulard V, DiMaggio PA, Fuchter MJ, Mecheri S, Mazier D, Scherf A, Malmquist NAet al., 2016, Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Brownstein NC, Guan X, Mao Y, Zhang Q, DiMaggio PA, Xia Q, Zhang L, Marshall AG, Young NLet al., 2015, Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 29, Pages: 659-666, ISSN: 0951-4198 Dattani R, Gibson KF, Few S, Borg AJ, DiMaggio PA, Nelson J, Kazarian SG, Cabral JTet al., 2015, Fullerene oxidation and clustering in solution induced by light, JOURNAL OF COLLOID AND INTERFACE SCIENCE, Vol: 446, Pages: 24-30, ISSN: 0021-9797 Horejs C-M, Serio A, Purvis A, Gormley AJ, Bertazzo S, Poliniewicz A, Wang AJ, DiMaggio P, Hohenester E, Stevens MMet al., 2014, Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 5908-5913, ISSN: 0027-8424 O'Connor CM, DiMaggio PA, Shenk T, Garcia BAet al., 2014, Quantitative Proteomic Discovery of Dynamic Epigenome Changes that Control Human Cytomegalovirus (HCMV) Infection, MOLECULAR & CELLULAR PROTEOMICS, Vol: 13, Pages: 2399-2410, ISSN: 1535-9476 Bartke T, Borgel J, DiMaggio PA, 2013, Proteomics in epigenetics: new perspectives for cancer research, BRIEFINGS IN FUNCTIONAL GENOMICS, Vol: 12, Pages: 205-218, ISSN: 2041-2649 Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJet al., 2013, On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 56, Pages: 8616-8625, ISSN: 0022-2623 Evertts AG, Zee BM, DiMaggio PA, Gonzales-Cope M, Coller HA, Garcia BAet al., 2013, Quantitative Dynamics of the Link between Cellular Metabolism and Histone Acetylation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 288, Pages: 12142-12151, ISSN: 0021-9258 LeRoy G, DiMaggio PA, Chan EY, Zee BM, Blanco MA, Bryant B, Flaniken IZ, Liu S, Kang Y, Trojer P, Garcia BAet al., 2013, A quantitative atlas of histone modification signatures from human cancer cells, EPIGENETICS & CHROMATIN, Vol: 6, ISSN: 1756-8935 Wu Y, DiMaggio PA, Perlman DH, Zakian VA, Garcia BAet al., 2013, Novel Phosphorylation Sites in the S. cerevisiae Cdc13 Protein Reveal New Targets for Telomere Length Regulation, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 316-327, ISSN: 1535-3893 Baliban RC, DiMaggio PA, Plazas-Mayorca MD, Garcia BA, Floudas CAet al., 2012, PILOT_PROTEIN: Identification of Unmodified and Modified Proteins via High-Resolution Mass Spectrometry and Mixed-Integer Linear Optimization, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 4615-4629, ISSN: 1535-3893 Baliban RC, Sakellari D, Li Z, DiMaggio PA, Garcia BA, Floudas CAet al., 2012, Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples, JOURNAL OF CLINICAL PERIODONTOLOGY, Vol: 39, Pages: 203-212, ISSN: 0303-6979 DiMaggio PA, Subramani A, Floudas CA, 2012, Novel biclustering methods for re-ordering data matrices, Fields Institute Communications, Vol: 63, Pages: 1-39, ISSN: 1069-5265 LeRoy G, Chepelev I, DiMaggio PA, Blanco MA, Zee BM, Zhao K, Garcia BAet al., 2012, Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins, GENOME BIOLOGY, Vol: 13, ISSN: 1474-7596 Yu Y, Song C, Zhang Q, DiMaggio PA, Garcia BA, York A, Carey MF, Grunstein Met al., 2012, Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA, MOLECULAR CELL, Vol: 46, Pages: 7-17, ISSN: 1097-2765 Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, DiMaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang S-C, Chen X, Chau I, Mangano TJ, Huang X-P, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin Jet al., 2011, A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells, NATURE CHEMICAL BIOLOGY, Vol: 7, Pages: 566-574, ISSN: 1552-4450 Baliban RC, DiMaggio PA, Plazas-Mayorca MD, Young NL, Garcia BA, Floudas CAet al., 2010, A Novel Approach for Untargeted Post-translational Modification Identification Using Integer Linear Optimization and Tandem Mass Spectrometry, MOLECULAR & CELLULAR PROTEOMICS, Vol: 9, Pages: 764-779, ISSN: 1535-9476 DiMaggio PA, Garcia BA, 2010, Mass Spectrometry Based Proteomics for Interrogating the Histone Code, CURRENT PROTEOMICS, Vol: 7, Pages: 177-187, ISSN: 1570-1646 DiMaggio PA, McAllister SR, Floudas CA, Feng X-J, Li G, Rabinowitz JD, Rabitz HAet al., 2010, Enhancing Molecular Discovery Using Descriptor-Free Rearrangement Clustering Techniques for Sparse Data Sets, AICHE JOURNAL, Vol: 56, Pages: 405-418, ISSN: 0001-1541 DiMaggio PA, McAllister SR, Floudas CA, Feng X-J, Rabinowitz JD, Rabitz HAet al., 2010, A network flow model for biclustering via optimal re-ordering of data matrices, 2nd International Conference on Complementarity, Duality and Global Optimization in Science and Engineering, Publisher: SPRINGER, Pages: 343-354, ISSN: 0925-5001