个人简介
2005年博士毕业于南开大学，2015年, 2018年访问美国宾夕法尼亚大学; 2008，2012年访问加拿大阿尔伯塔大学。主要从事结构生物信息学、单细胞RNA测序分析，深度学习在生物信息中的应用等方向的研究工作。主持并完成国家自然科学基金青年项目1项，已发表SCI学术论文16篇，其中第一作者或通讯作者6篇。
近期论文
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Propensity score matching enables batch-effect-corrected imputation in single-cell RNA-seq analysis
Briefings in Bioinformatics
2022-07-18 | Journal article
DOI: 10.1093/bib/bbac275
Contributors: Xinyi Xu; Xiaokang Yu; Gang Hu; Kui Wang; Jingxiao Zhang; Xiangjie Li
A joint deep learning model enables simultaneous batch effect correction, denoising and clustering in single-cell transcriptomics
Justin Lakkis, David Wang, Yuanchao Zhang, Gang Hu, Kui Wang, Huize Pan, Lyle Ungar, Muredach Reilly, Xiangjie Li, Mingyao Li.
Genome Research, 2021, gr. 271874.120
Lyu, Y., Zauhar, R., Dana, N. et al. Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profiling. Sci Rep 11, 15612 (2021). https://doi.org/10.1038/s41598-021-95122-3
Hu G#, Katuwawala A#, Wang K#, Wu Z, Ghadermarzi S, Gao J., Kurgan L*, flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions. Nat Commun 12, 4438 (2021).
Nguyen AT#, Wang K#, Hu G#, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M*, Lee EB*. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathol. 2020 Aug 25. doi: 10.1007/s00401-020-02200-3.
Li X, Wang K, Lyu Y, Pan H, Zhang J, Stambolian D, Susztak K, Reilly MP, Hu G, Li M. Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis. Nature Communications. 2020 May 11;11(1):1-4.
Gao J, Wu Z, Hu G, Wang K, Song J, Joachimiak A, Kurgan L. Survey of predictors of propensity for protein production and crystallization with application to predict resolution of crystal structures. Current Protein and Peptide Science. 2018 Feb 1;19(2):200-10.
Hu Y, Lin J, Hu J, Hu G, Wang K, Zhang H, Reilly MP, Li M. PennDiff: detecting differential alternative splicing and transcription by RNA sequencing. Bioinformatics. 2018 Jul 15;34(14):2384-91.
Hu G#, Wang K#, Song J, Uversky VN, Kurgan L. Taxonomic landscape of the dark proteomes: Whole‐proteome scale interplay between structural darkness, intrinsic disorder, and crystallization propensity. Proteomics. 2018 Nov;18(21-22):1800243.
Wu Z, Hu G, Wang K, et al. What are the structural features that drive partitioning of proteins in aqueous two-phase systems?[J]. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2017, 1865(1): 113-120.
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