Hellyer, Peter - Imperial College London - Department of Bioengineering

研究领域

Peter's research uses a combination of structural and functional magnetic resonance imaging (fMRI and DTI) to study the relationship between the dynamic functional activity of the brain, neural structure and cognition. Using tractography based on Diffusion Tensor Imaging to map the strucutral connectivity of the healthy brain, he uses novel computational modeling constrained by the white matter structure of the brain combined with Machine Learning (MVPA) and data compression approaches such as Independent Component Analysis (ICA), to decompose and predict the dynamical properties the human brain. White Matter Network Mapping White Matter Connectivity of the Brain In particular, Peter is interested in the interaction between white matter disconnection, global measures of neural dynamics, and cognitive outcome following traumatic brain injury (TBI). Peter studied for his PhD under the supervision of Dr. Robert Leech, Prof. Richard Wise and Prof. David Sharp at Imperial College London. In addition, Peter has a BSc. (Hons) in Neuroscience from Kings College London and an MRes in Experimental Neuroscience from Imperial College London Beyond Neuroscience, Peter is also interested in the development and application of High Performance Computing (HPC) for research and is responsible for provision and support of C3NL HPC services.

近期论文

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Braga RM, Hellyer PJ, Wise RJ, Leech Ret al., 2016, Auditory and visual connectivity gradients in frontoparietal cortex., Hum Brain Mapp Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, Tagliazucchi E, Schenberg EE, Nest T, Orban C, Leech R, Williams LT, Williams TM, Bolstridge M, Sessa B, McGonigle J, Sereno MI, Nichols D, Hellyer PJ, Hobden P, Evans J, Singh KD, Wise RG, Curran HV, Feilding A, Nutt DJet al., 2016, Neural correlates of the LSD experience revealed by multimodal neuroimaging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 4853-4858, ISSN: 0027-8424 Hampshire A, Hellyer PJ, Parkin B, Hiebert N, MacDonald P, Owen AM, Leech R, Rowe Jet al., 2016, Network mechanisms of intentional learning, NEUROIMAGE, Vol: 127, Pages: 123-134, ISSN: 1053-8119 Hellyer PJ, Jachs B, Clopath C, Leech Ret al., 2016, Local inhibitory plasticity tunes macroscopic brain dynamics and allows the emergence of functional brain networks, NEUROIMAGE, Vol: 124, Pages: 85-95, ISSN: 1053-8119 Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJet al., 2016, Amyloid pathology and axonal injury after brain trauma, NEUROLOGY, Vol: 86, Pages: 821-828, ISSN: 0028-3878 Fagerholm ED, Hellyer PJ, Scott G, Leech R, Sharp DJet al., 2015, Disconnection of network hubs and cognitive impairment after traumatic brain injury, BRAIN, Vol: 138, Pages: 1696-1709, ISSN: 0006-8950 Fagerholm ED, Lorenz R, Scott G, Dinov M, Hellyer PJ, Mirzaei N, Leeson C, Carmichael DW, Sharp DJ, Shew WL, Leech Ret al., 2015, Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 4626-4634, ISSN: 0270-6474 Hellyer PJ, Scott G, Shanahan M, Sharp DJ, Leech Ret al., 2015, Cognitive Flexibility through Metastable Neural Dynamics Is Disrupted by Damage to the Structural Connectome, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 9050-9063, ISSN: 0270-6474 Nigmatullina Y, Hellyer PJ, Nachev P, Sharp DJ, Seemungal BMet al., 2015, The Neuroanatomical Correlates of Training-Related Perceptuo-Reflex Uncoupling in Dancers, CEREBRAL CORTEX, Vol: 25, Pages: 554-562, ISSN: 1047-3211 Parkin BL, Hellyer PJ, Leech R, Hampshire Aet al., 2015, Dynamic Network Mechanisms of Relational Integration, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 7660-7673, ISSN: 0270-6474 Scott G, Hellyer PJ, Hampshire A, Leech Ret al., 2015, Exploring Spatiotemporal Network Transitions in Task Functional MRI, HUMAN BRAIN MAPPING, Vol: 36, Pages: 1348-1364, ISSN: 1065-9471 Scott G, Hellyer PJ, Ramlackhansingh AF, Brooks DJ, Matthews PM, Sharp DJet al., 2015, Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage, JOURNAL OF NEUROINFLAMMATION, Vol: 12, ISSN: 1742-2094 Vasa F, Shanahan M, Hellyer PJ, Scott G, Cabral J, Leech Ret al., 2015, Effects of lesions on synchrony and metastability in cortical networks, NEUROIMAGE, Vol: 118, Pages: 456-467, ISSN: 1053-8119 Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, Chialvo DR, Nutt Det al., 2014, The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 8, ISSN: 1662-5161 Ham TE, Bonnelle V, Hellyer P, Jilka S, Robertson IH, Leech R, Sharp DJet al., 2014, The neural basis of impaired self-awareness after traumatic brain injury, BRAIN, Vol: 137, Pages: 586-597, ISSN: 0006-8950 Hellyer PJ, Shanahan M, Scott G, Wise RJS, Sharp DJ, Leech Ret al., 2014, The Control of Global Brain Dynamics: Opposing Actions of Frontoparietal Control and Default Mode Networks on Attention, JOURNAL OF NEUROSCIENCE, Vol: 34, Pages: 451-461, ISSN: 0270-6474 Kwok H-T, Baxter D, DeFelice J, Hellyer P, Kirkman E, Watts S, Midwinter M, Gentleman S, Sharp Det al., 2014, The neuropathology of blast traumatic brain injury in a porcine polytrauma model, BRAIN INJURY, Vol: 28, Pages: 779-780, ISSN: 0269-9052 Monti RP, Hellyer P, Sharp D, Leech R, Anagnostopoulos C, Montana Get al., 2014, Estimating time-varying brain connectivity networks from functional MRI time series, NEUROIMAGE, Vol: 103, Pages: 427-443, ISSN: 1053-8119 Nigmatullina Y, Hellyer PM, Nachev P, Sharp D, Seemungal BMet al., 2014, The neuroanatomical correlates of vestibular adaptation in ballet dancers, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 278-278, ISSN: 1351-5101 Nigmatullina Y, Hellyer PM, Nachev P, Sharp D, Seemungal BMet al., 2014, The neuroanatomical correlates of vestibular adaptation in ballet dancers, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S190-S191, ISSN: 0340-5354