Foust, Amanda - Imperial College London - Department of Bioengineering

个人简介

The ability to manipulate and track neuronal communication is essential to understanding the mechanisms underlying our sensations, perceptions, thoughts, emotions and actions. With a growing toolbox of optical dyes, genetic sensors and actuators, Neuroscience has made science fiction-scale progress toward realizing this important prerequisite for neural circuit reverse engineering. A parallel revolution in photonics research is taking shape to exploit the full potential of photo-molecular tools for brain circuit interrogation. My goal is to engineer bridges between recent optical technology and Neurophysiologists endeavoring to close the loop between theory and experimentation.

研究领域

The ability to manipulate and track neuronal communication is essential to understanding the mechanisms underlying our sensations, perceptions, thoughts, emotions and actions. With a growing toolbox of optical dyes, genetic sensors and actuators, Neuroscience has made science fiction-scale progress toward realizing this important prerequisite for neural circuit reverse engineering. A parallel revolution in photonics research is taking shape to exploit the full potential of photo-molecular tools for brain circuit interrogation. My goal is to engineer bridges between recent optical technology and Neurophysiologists endeavoring to close the loop between theory and experimentation.

近期论文

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Foust, A. J., Beiu, R. M., Rector, D. M., April 2005. Optimized birefringence changes during isolated nerve activation. Applied optics 44 (11), 2008-2012. Yao, X. C., Foust, A., Rector, D. M., Barrowes, B., George, J. S., June 2005. Cross-polarized reflected light measurement of fast optical responses associated with neural activation. Biophysical Journal 88 (6), 4170-4177. Foust, A. J., Rector, D. M., March 2007. Optically teasing apart neural swelling and depolarization. Neuroscience 145 (3), 887-899. McCluskey, M. D., Sable, J. J., Foust, A. J., Gratton, G., Rector, D. M., April 2007. Recording invertebrate nerve activation with modulated light changes. Applied Optics 46 (10), 1866-1871. Foust, A. J., Schei, J. L., Rojas, M. J., Rector, D. M., 2008. In vitro and in vivo noise analysis for optical neural recording. Journal of Biomedical Optics 13 (4). Schei, J. L., McCluskey, M. D., Foust, A. J., Yao, X. C., Rector, D. M., April 2008. Action potential propagation imaged with high temporal resolution near-infrared video microscopy and polarized light. NeuroImage 40 (3), 1034-1043. Schei, J. L., Foust, A. J., Rojas, M. J., Navas, J. A., Rector, D. M., April 2009. State-dependent auditory evoked hemodynamic responses recorded optically with indwelling photodiodes. Applied Optics 48 (10). Foust, A., Popovic, M., Zecevic, D., McCormick, D. A., May 2010. Action potentials initiate in the axon initial segment and propagate through axon collaterals reliably in cerebellar Purkinje neurons. Journal of Neuroscience 30(20),6891-902. Popovic, M., Foust, A. J., McCormick, D. A., Zecevic, D., Spatial profile of membrane potential changes during action potential initiation and propagation in axons of layer 5 cortical pyramidal neurons. Journal of Physiology. 589(17):4167-4187 Foust, A. J., Popovic, M., Zecevic, D., McCormick, D. A., 2011. Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons. J Neurosci 31(43):15490-15498. Foust, A. J., Zampini, V., Tanese, D., Papagiakoumou, E., Emiliani, V., 2015. Computer generated holography enhances voltage dye fluorescence discrimination in adjacent neuronal structures. Neurophotonics 2(2):021007. Casale, A. E., Foust, A. J., Bal, T., McCormick, D. A., 2015. Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties. J Neurosci 35(47):15555-15567.