Weinberg, Peter - Imperial College London - Department of Bioengineering

个人简介

Professor Peter Weinberg won a scholarship to Cambridge, where he read Natural Sciences. He then obtained a DIC, MSc and PhD from Imperial College, the latter being obtained in the Physiological Flow Studies Unit. After being awarded a Lady Davis Fellowship in the Department of Bioengineering at the Technion, Israel, and further postdoctoral studies in the Physiological Flow Studies Unit, he was appointed Lecturer and then Reader in the School of Animal and Microbial Sciences, University of Reading. In 2004, he returned to Imperial College as a Reader in the Department of Bioengineering, and was appointed Professor of Cardiovascular Mechanics there in 2007. Professor Weinberg’s research is chiefly concerned with elucidating mechanisms involved in the development of atherosclerosis. He has developed a new theory relating the anatomically patchy distribution of atherosclerosis to variation in blood flow, endothelial nitric oxide synthesis and uptake of plasma macromolecules by the arterial wall. He is also developing methods of pulsewave analysis for assessing nitric oxide synthesis non-invasively, and is studying the large differences in vascular fluid mechanics that occur between species of different size. The work has been funded by BBSRC, EPSRC, MRC, BHF and the Wellcome Trust. He has been elected Fellow of the Royal Microscopical Society, Ordinary Member of the Physiological Society, Member of the British Atherosclerosis Society, Committee Member of the London Microcirculation Group, Committee Member of the British Society for Cardiovascular Research and Committee Member of the British Atherosclerosis Society. He was also a member of the Steering Committee of the EPSRC-funded Network in Physiological Flow Modelling and is Vice Chair of the Cardiovascular Technology Network. He has helped organise numerous conferences including the first joint meeting of the British Society for Cardiovascular Research and the British Atherosclerosis Society.

研究领域

Development of a novel theory to account for the patchy nature of atherosclerosis within the arterial system: the theory suggests a key role for arterial wall permeability to circulating lipoproteins, which in turn depends on blood flow and nitric oxide synthesis, and inconsistencies encountered by previous theories are avoided by taking into account the changes in these phenomena that occur with age Development of novel techniques of digital imaging fluorescence microscopy and confocal microscopy for mapping protein transport, endothelial cell morphology and arterial lipid deposition Assessment of flows occurring at arterial branch sites from endothelial cell morphology and computational fluid dynamics Development of noninvasive methods, based on analysis of the peripheral pulse wave, for assessing nitric oxide bioactivity in large arteries Investigation of the molecular mechanisms by which dietary constituents (particularly isoflavones and L-arginine) protect against atherosclerosis Identifying the scaling laws determining differences in vascular fluid mechanics between animals of different size, and studying how vascular cells adapt to these differences Characterisation of atherosclerotic plaque content by FTIR spectroscopy Studying the interaction between atherosclerotic plaque formation, endothelial nitric oxide production and vascular remodelling

近期论文

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Chooi KY, Comerford A, Cremers SJ, Weinberg PDet al., 2016, Role of endothelial permeability hotspots and endothelial mitosis in determining age-related patterns of macromolecule uptake by the rabbit aortic wall near branch points, ATHEROSCLEROSIS, Vol: 250, Pages: 77-83, ISSN: 0021-9150 Chooi KY, Comerford A, Sherwin SJ, Weinberg PDet al., 2016, Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study., J R Soc Interface, Vol: 13 Bailey EL, Bazigou E, Sowinski PSJ, Weinberg PDet al., 2015, Mass Transport Properties of the Rabbit Aortic Wall, PLOS ONE, Vol: 10, ISSN: 1932-6203 Comerford A, Chooi KY, Nowak M, Weinberg PD, Sherwin SJet al., 2015, A combined numerical and experimental framework for determining permeability properties of the arterial media, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 14, Pages: 297-313, ISSN: 1617-7959 Leow CH, Bazigou E, Eckersley RJ, Yu ACH, Weinberg PD, Tang M-Xet al., 2015, FLOW VELOCITY MAPPING USING CONTRAST ENHANCED HIGH-FRAME-RATE PLANE WAVE ULTRASOUND AND IMAGE TRACKING: METHODS AND INITIAL IN VITRO AND IN VIVO EVALUATION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 41, Pages: 2913-2925, ISSN: 0301-5629 Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PDet al., 2015, Change of Direction in the Biomechanics of Atherosclerosis, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 43, Pages: 16-25, ISSN: 0090-6964 Rowland EM, Mohamied Y, Chooi KY, Bailey EL, Weinberg PDet al., 2015, Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 137, ISSN: 0148-0731 Alastruey J, Hunt AAE, Weinberg PD, 2014, Novel wave intensity analysis of arterial pulse wave propagation accounting for peripheral reflections, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, Vol: 30, Pages: 249-279, ISSN: 2040-7939 Bailey EL, Peiffer V, Mohamied Y, Chooi KY, Rowland EM, Sherwin SJ, Weinberg PDet al., 2014, SPATIAL CORRELATION BETWEEN PATTERNS OF WALL PERMEABILITY AND PATTERNS OF MULTIDIRECTIONAL DISTURBED BLOOD FLOW IN RABBIT AORTA, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E2-E2, ISSN: 0021-9150 Bailey EL, Sowinski P, Bazigou E, Weinberg PDet al., 2014, DEVELOPING A MODEL OF GLOBAL ARTERIAL STIFFENING TO ASSESS THE EFFECT OF VASCULAR AGING ON LOCAL RISK FACTORS FOR ATHEROSCLEROSIS, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E4-E4, ISSN: 0021-9150 Bazigou E, Bailey E, Sowinski P, Fraser KH, Chow K, Weinberg PDet al., 2014, UNILATERAL NEPHRECTOMY AS A MODEL OF ALTERED BLOOD FLOW FOR THE STUDY OF ARTERIAL PERMEABILITY, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E4-E5, ISSN: 0021-9150 Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R, Weinberg PDet al., 2014, ELEVATED ARTERIAL WALL PERMEABILITY MAY CAUSE VULNERABLE PLAQUE FORMATION IN MICE, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E6-E6, ISSN: 0021-9150 Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ, Weinberg PDet al., 2014, Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model, PLoS One, Vol: 9, ISSN: 1932-6203 Vincent PE, Weinberg PD, 2014, Flow-dependent concentration polarization and the endothelial glycocalyx layer: multi-scale aspects of arterial mass transport and their implications for atherosclerosis, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 13, Pages: 313-326, ISSN: 1617-7959 Wen Y, Satchell L, Gibson TM, Weinberg PD, Leake DSet al., 2014, LOW DENSITY LIPOPROTEIN AGGREGATED BY SPHINGOMYELINASE IS INTERNALISED BY MACROPHAGES AND OXIDISED IN LYSOSOMES, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E5-E6, ISSN: 0021-9150 Lomax MA, Karamanlidis G, Laws J, Cremers SG, Weinberg PD, Clarke Let al., 2013, Pigs fed saturated fat/cholesterol have a blunted hypothalamic-pituitary-adrenal function, are insulin resistant and have decreased expression of IRS-1, PGC1 alpha and PPAR alpha, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol: 24, Pages: 656-663, ISSN: 0955-2863 Peiffer V, Bharath AA, Sherwin SJ, Weinberg PDet al., 2013, A Novel Method for Quantifying Spatial Correlations Between Patterns of Atherosclerosis and Hemodynamic Factors, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 135, ISSN: 0148-0731 Peiffer V, Sherwin SJ, Weinberg PD, 2013, Does low and oscillatory wall shear stress correlate spatially with early atherosclerosis? A systematic review, CARDIOVASCULAR RESEARCH, Vol: 99, Pages: 242-250, ISSN: 0008-6363 Peiffer V, Sherwin SJ, Weinberg PD, 2013, Computation in the rabbit aorta of a new metric - the transverse wall shear stress - to quantify the multidirectional character of disturbed blood flow, JOURNAL OF BIOMECHANICS, Vol: 46, Pages: 2651-2658, ISSN: 0021-9290 Zhou B, Fraser KH, Poelma C, Mari J-M, Eckersley RJ, Weinberg PD, Tang M-Xet al., 2013, ULTRASOUND IMAGING VELOCIMETRY: EFFECT OF BEAM SWEEPING ON VELOCITY ESTIMATION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 39, Pages: 1672-1681, ISSN: 0301-5629