Tanaka, Reiko J. - Imperial College London - Department of Bioengineering

个人简介

With her special interest in regulatory mechanisms in biological systems combined with her background in engineering systems and control theory, Dr Tanaka aims to search for fundamental rules and mechanisms of biological control from the viewpoint of control, and to make a decisive contribution to systems medicine and biology. Mathematical modelling allows us to investigate and extract common design principles in diverse systems across the cellular, tissue, organ and behavioural levels. Since most diseases are caused by malfunctioning of various regulatory mechanisms, understanding of common control design principles helps to identify key mechanisms to investigate and to propose and answer clinically/biologically relevant questions that could not even te posed without it. For the detail of her research interests, please see TANAKA Group. Reiko has experiences in multi-disciplinary research and education environements in different research organisations in several countries. After she obtained her PhD from the Department of Mathematical Engineering and Information Physics, University of Tokyo, she was appointed as an Assistant Professor in the Department of Applied Physics and Physico-Informatics, Keio University. With her strong interest in the new area of systems biology, she obtained a fellowship from JSPS (Japan Society for the Promotion of Science) to join Professor John Doyle''s group in California Institute of Technology as a Visiting Associate. Since then she has been working in the area of systems biology from the systems and control viewpoint. Before joining Imperial, she was a research scientist in Biological Control Systems lab. in RIKEN.

研究领域

Mathematical modelling of multi-scale regulatory mechanisms In silico approach to study onset, progression and prevention of atopic dermatitis In silico modelling of fungal infection Development of new mathematical tools for systems dermatology Regulatory mechanisms for T cell development and homeostasis

近期论文

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Domínguez-Hüttinger E, Christodoulides P, Miyauchi K, Irvine AD, Okada-Hatakeyama M, Kubo M, Tanaka RJet al., Mathematical modeling of atopic dermatitis reveals "double switch" mechanisms underlying four common disease phenotypes, Journal of Allergy and Clinical Immunology, ISSN: 1097-6825 Yokouchi M, Atsugi T, van Logtestijn M, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo Aet al., Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape, eLife, ISSN: 2050-084X Lee SY, Boon NJ, Webb AA, Tanaka RJet al., 2016, Synergistic Activation of RD29A Via Integration of Salinity Stress and Abscisic Acid in Arabidopsis thaliana., Plant Cell Physiol Ono M, Tanaka RJ, 2016, Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective, IMMUNOLOGY AND CELL BIOLOGY, Vol: 94, Pages: 3-10, ISSN: 0818-9641 van Logtestijn MDA, Caspers PJ, Kezic S, Hoffman DR, Koenig DW, Ono M, Stamatas GN, Tanaka RJet al., 2016, Water resistance profile as a marker of skin barrier damage in atopic dermatitis patients, JOURNAL OF DERMATOLOGICAL SCIENCE, Vol: 81, Pages: 126-128, ISSN: 0923-1811 Huettinger ED, Christodoulides P, Tanaka RJ, 2015, Mathematical modelling approach to elucidate multi-scale regulatory mechanisms for stratum corneum homeostasis, INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol: 37, Pages: 143-144, ISSN: 0142-5463 Tanaka RJ, Boon NJ, Vrcelj K, Nguyen A, Vinci C, Armstrong-James D, Bignell Eet al., 2015, In silico modeling of spore inhalation reveals fungal persistence following low dose exposure, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322 van Logtestijn MDA, Dominguez Huttinger E, Stamatas GN, Tanaka RJet al., 2015, Resistance to Water Diffusion in the Stratum Corneum Is Depth-Dependent, PLOS One, Vol: 10, ISSN: 1932-6203 Boon N, Bignell E, Tanaka RJ, 2014, In silico prediction of the temporal effects of anti-fungal treatments, IMMUNOLOGY, Vol: 143, Pages: 58-58, ISSN: 0019-2805 Dominguez-Huttinger E, Clarke TB, Tanaka RJ, 2014, Mathematical modelling of host pathogen interactions at mucosal surfaces reveals the dual role of the epithelial barrier in determining the outcome of infectious processes, IMMUNOLOGY, Vol: 143, Pages: 150-150, ISSN: 0019-2805 Huettinger ED, Christodoulides P, Tanaka RJ, 2014, Uncovering risk factor-dependent mechanisms for development of atopic dermatitis using a systems biology approach, 8th Georg Rajka Symposium on Atopic Dermatitis (ISAD), Publisher: WILEY-BLACKWELL, Pages: E30-E30, ISSN: 0007-0963 Ono M, Tanaka RJ, Kano M, 2014, Visualisation of the T cell differentiation programme by Canonical Correspondence Analysis of transcriptomes, BMC Genomics, Vol: 15, ISSN: 1471-2164 Sabatier Q, Krapp HG, Tanaka RJ, 2014, Dynamic optimisation for fly gaze stabilisation based on noisy and delayed sensor information, 13th European Control Conference (ECC), Publisher: IEEE, Pages: 1783-1788 Dominguez-Huettinger E, Ono M, Barahona M, Tanaka RJet al., 2013, Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasis, INTERFACE FOCUS, Vol: 3, ISSN: 2042-8898 Ejaz N, Krapp HG, Tanaka RJ, 2013, Closed-loop response properties of a visual interneuron involved in fly optomotor control, FRONTIERS IN NEURAL CIRCUITS, Vol: 7, ISSN: 1662-5110 Ono M, Tanaka RJ, Kano M, Sugiman Tet al., 2013, Visualising the Cross-Level Relationships between Pathological and Physiological Processes and Gene Expression: Analyses of Haematological Diseases, PLOS ONE, Vol: 8, ISSN: 1932-6203 Tanaka RJ, Ono M, 2013, Skin Disease Modeling from a Mathematical Perspective, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 133, Pages: 1472-1478, ISSN: 0022-202X Dominguez-Huttinger E, Ono M, Barahona M, Tanaka RJet al., 2012, System-level investigation of risk factors for atopic dermatitis by mathematical modelling and analysis, 42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Publisher: NATURE PUBLISHING GROUP, Pages: S25-S25, ISSN: 0022-202X Ejaz N, Tanaka RJ, Krapp HG, 2012, Static versus Adaptive Gain Control Strategy for Visuo-motor Stabilization., Publisher: Springer, Pages: 107-119 Huettinger ED, Ono M, Barahona M, Tanaka RJet al., 2012, Mathematical model of the development of Atopic dermatitis, 22nd IUBMB Congress/37th FEBS Congress, Publisher: WILEY-BLACKWELL, Pages: 523-523, ISSN: 1742-464X