Stevens, Molly - Imperial College London

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Imperial College London Department of Materials
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个人简介

Molly Stevens is currently Professor of Biomedical Materials and Regenerative Medicine and the Research Director for Biomedical Material Sciences in the Institute of Biomedical Engineering at Imperial College. She joined Imperial in 2004 after a Postdoctoral training in the laboratory of Professor Robert Langer in the Chemical Engineering Department at the Massachusetts Institute of Technology (MIT). Prior to this she graduated from Bath University with a First Class Honours degree in Pharmaceutical Sciences and was then awarded a PhD in biophysical investigations of specific biomolecular interactions and single biomolecule mechanics from the Laboratory of Biophysics and Surface Analysis at the University of Nottingham (2000). In 2010 she was recognised by The Times as one of the top ten scientists under the age of 40 and also received the Polymer International-IUPAC award for creativity in polymer science, the Rosenhain medal and the Norman Heatley Prize for Interdisciplinary research from the Royal Society of Chemistry. In 2009 she was awarded the Jean Leray Award from the European Society for Biomaterials, in 2007 the prestigious Conference Science Medal from the Royal Pharmaceutical Society and in 2005 the Philip Leverhulme Prize for Engineering. She has also recently been recognised by the TR100, a compilation of the top innovators, under the age of 35, who are transforming technology - and the world with their work. Her previous awards include the Ronald Belcher Memorial Lecture Award from the Royal Society of Chemistry (2000) and both the Janssen Prize and the UpJohn Prize for academic excellence and research. In 2010 Molly was awarded the RSC Norman Heatley Prize and the IOM3 Rosenhain Medal and Prize, In 2012 Molly was awarded the Griffith Prize and medal from IOM3. In 2012 she presented the Royal Society Clifford Patterson Lecture and in 2013 she was elected Fellow of the Royal Academy of Engineering. She has a large and extremely multidisciplinary research group of students and postdocs/fellows. The group is focused on both high quality fundamental science and translation for human health. Research in regenerative medicine within her group includes the directed differentiation of stem cells, the design of novel bioactive scaffolds and new approaches towards tissue regeneration. She has developed novel approaches to tissue engineering that are likely to prove very powerful in the engineering of large quantities of human mature bone for autologous transplantation as well as other vital organs such as liver and pancreas, which have proven elusive with other approaches. This has led to moves to translate the technology (including the founding of spin-out companies). In the field of nanotechnology the group has current research efforts in exploiting specific biomolecular recognition and self-assembly mechanisms to create new dynamic nano-materials, biosensors and drug delivery systems. Recent efforts by the Stevens group in peptide-functionalised nanoparticles for enzyme biosensing have enabled the most sensitive facile enzyme detection to date and have a host of applications across diseases ranging from cancer to global health applications.

研究领域

The group is extremely multidisciplinary and currently consists of around 30 postdoctoral fellows and PhD students. The group is focussed on both high quality fundamental science and translation for human health. Research in regenerative medicine within the group includes the directed differentiation of stem cells, the design of novel bioactive scaffolds and new approaches towards tissue regeneration. We have developed novel approaches to tissue engineering that are likely to prove very powerful in the engineering of large quantities of human mature bone for autologous transplantation as well as other vital organs such as liver and pancreas, which have proven elusive with other approaches. This has led to moves to commercialise the technology (Prof Stevens is the co-founder of spin-out companies) and set-up a clinical trial for bone regeneration in humans. In the field of nanotechnology the group has current research efforts in exploiting specific biomolecular recognition and self-assembly mechanisms to create new dynamic nano-materials, biosensors and drug delivery systems. Recent efforts by the Stevens group in peptide-functionalised nanoparticles for enzyme biosensing have enabled the most sensitive facile enzyme detection to date and have a host of applications across diseases ranging from cancer to global health applications.

近期论文

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Higgins S, Becce M, Belessiotis Richards A, Seong H, Sero J, Stevens Met al., High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials, Advanced Materials Hachim D, Whittaker TE, Kim H, Stevens Met al., Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: making the right choices, Journal of Controlled Release, ISSN: 0168-3659 Loynachan C, Soleimany AP, Dudani JS, Lin Y, Najer A, Bekdemir A, Chen Q, Bhatia SN, Stevens Met al., Renal clearable catalytic gold nanoclusters for in vivo disease monitoring, Nature Nanotechnology, ISSN: 1748-3387 Wang S-T, Lin Y, NIelsen MH, Song CY, Thomas MT, Spicer C, Kroger R, Ercius P, Aloni S, Stevens Met al., 2019, Shape-controlled synthesis and in situ characterisation of anisotropic AU nanomaterials using liquid cell transmission electron microscopy, Nanoscale, Vol: 36, Pages: 16801-16809, ISSN: 2040-3364 Hansel C, Holme M, Gopal S, Stevens Met al., 2019, Advances in high-resolution microscopy for the study of intracellular interactions with biomaterials, Biomaterials, ISSN: 0142-9612 Armstrong J, Stevens M, Using remote fields for complex tissue engineering, Trends in Biotechnology, ISSN: 0167-7799 Autefage H, Allen F, Tang HM, Kallepitis C, Gentleman E, Reznikov N, Nitiputri K, Nommeots-Nomm A, Young G, Lee PD, Pierce BF, Wagermaier W, Fratzl P, Goodship A, Jones JR, Blunn G, Stevens Met al., 2019, Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass, Biomaterials, Vol: 209, Pages: 152-162, ISSN: 0142-9612 Barrioni BR, Naruphontjirakul P, Norris E, Li S, Kelly NL, Hanna J, Stevens MM, Jones JR, Pereira MDMet al., 2019, Effects of manganese incorporation on the morphology, structure and cytotoxicity of spherical bioactive glass nanoparticles, Journal of Colloid and Interface Science, Vol: 547, Pages: 382-392, ISSN: 0021-9797 Belessiotis-Richards A, Higgins SG, Butterworth B, Stevens MM, Alexander-Katz Aet al., 2019, Single-nanometer changes in nanopore geometry influence curvature, local properties, and protein localization in membrane simulations, Nano Letters, ISSN: 1530-6984 Wang Y, Kim E, Lin Y, Kim N, Kit-Anan W, Gopal S, Agarwal S, Howes P, Stevens Met al., 2019, Rolling circle transcription-amplified hierarchically structured organic-inorganic hybrid RNA flowers for enzyme immobilization, ACS Applied Materials and Interfaces, ISSN: 1944-8244 Gopal S, Chiappini C, Armstrong J, Chen Q, Serio A, Hsu C, Meinert C, Klein TJ, Hutmacher DW, Stevens Met al., 2019, Immunogold FIB-SEM: combining volumetric ultrastructure visualization with 3D biomolecular analysis to dissect cell-environment interactions, Advanced Materials, ISSN: 0935-9648 Kim H, Park Y, Stevens MM, Kwon W, Hahn SKet al., 2019, Multifunctional hyaluronate - nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications, Journal of Controlled Release, Vol: 303, Pages: 55-66, ISSN: 0168-3659 Ghouse S, Reznikov N, Boughton O, Babu S, Ng KCG, Blunn G, Cobb J, Stevens M, Jeffers Jet al., 2019, The design and in vivo testing of a locally stiffness-matched porous scaffold, Applied Materials Today, Vol: 15, Pages: 377-388, ISSN: 2352-9407 Zhao S, Caruso F, Dähne L, Decher G, De Geest BG, Fan J, Feliu N, Gogotsi Y, Hammond PT, Hersam MC, Khademhosseini A, Kotov N, Leporatti S, Li Y, Lisdat F, Liz-Marzán LM, Moya S, Mulvaney P, Rogach AL, Roy S, Shchukin DG, Skirtach AG, Stevens MM, Sukhorukov GB, Weiss PS, Yue Z, Zhu D, Parak WJet al., 2019, The future of layer-by-layer assembly: A tribute to ACS Nano associate editor Helmuth Möhwald, ACS Nano, ISSN: 1936-0851 Mohammed AA, Aviles Milan J, Li S, Chung JJ, Stevens MM, Georgiou TK, Jones JRet al., 2019, Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase, Journal of Materials Chemistry B, ISSN: 2050-750X Nele V, Holme M, Kauscher U, Thomas MR, Doutch JJ, Stevens Met al., 2019, Effect of formulation method, lipid composition and PEGylation on vesicle lamellarity: a small-angle neutron scattering study, Langmuir, Vol: 35, Pages: 6064-6074, ISSN: 0743-7463 Armstrong J, Stevens M, 2019, Emerging technologies for tissue engineering: from gene editing to personalized medicine, Tissue Engineering: Parts A, B, and C, Vol: 25, ISSN: 1937-3341 Li C, Ouyang L, Pence I, Moore A, Lin Y, Winter C, Armstrong J, Stevens Met al., 2019, Buoyancy-driven gradients for biomaterial fabrication and tissue engineering, Advanced Materials, Vol: 31, ISSN: 0935-9648 Paxton NC, Ren J, Ainsworth MJ, Solanki AK, Jones JR, Allenby MC, Stevens M, Woodruff MAet al., 2019, Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive Gglass/polycaprolactone microfibers, Macromolecular Rapid Communications, ISSN: 1022-1336 Kim E, Agarwal S, Kim N, Hage FS, Gelmi A, Stevens Met al., 2019, Bio-inspired fabrication of DNA-inorganic hybrid composites using synthetic DNA, ACS Nano, Vol: 13, Pages: 2888-2900, ISSN: 1936-0851 Hansel C, Crowder S, Cooper S, Gopal S, Pardelha da Cruz J, De Oliveira Martins L, Keller D, Rothery S, Becce M, Cass A, Bakal C, Chiappini C, Stevens Met al., 2019, Nanoneedle-mediated stimulation of cell mechanotransduction machinery, ACS Nano, Vol: 13, Pages: 2913-2019, ISSN: 1936-0851 Gopal S, Chiappini C, Penders J, Leonardo V, Seong H, Rothery S, Korchev Y, Shevchuk A, Stevens MMet al., 2019, Porous silicon nanoneedles modulate endocytosis to deliver biological payloads, Advanced Materials, Vol: 31, ISSN: 0935-9648 Ferrini A, Stevens MM, Sattler S, Rosenthal Net al., 2019, Toward regeneration of the heart: Bioengineering strategies for immunomodulation, Frontiers in Cardiovascular Medicine, Vol: 6, ISSN: 2297-055X Barriga HMG, Holme MN, Stevens MM, 2019, Cubosomes: the next generation of smart lipid nanoparticles?, Angewandte Chemie, Vol: 58, Pages: 2958-2978, ISSN: 1521-3757 Wood CS, Thomas M, Budd J, Mashamba-Thompson TP, Herbst K, Pillay D, Peeling RW, Johnson AM, McKendry RA, Stevens Met al., 2019, Taking connected mobile-health diagnostics of infectious diseases to the field., Nature, Vol: 566, Pages: 467-474, ISSN: 0028-0836

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