Stan, Guy-Bart - Imperial College London - Department of Bioengineering

个人简介

My name is Guy-Bart STAN. I am a permanent academic member of staff in the Department of Bioengineering and the head of the Control Engineering Synthetic Biology group in the Synthetic Biology Hub of Imperial College London (U.K.). I am the recipient of the prestigious EPSRC Engineering Fellowship for Growth in Synthetic Biology for the period January 2015 - January 2020. I am also a Chartered Engineer (IET CEng) and a member of the The Institution of Engineering and Technology (The IET) and the The Institute of Electrical and Electronics Engineers (The IEEE). I joined Imperial College in December 2009 as a Lecturer and got promoted to Reader in August 2014. From January 2006 until December 2009, I worked in the Control Group of the University of Cambridge (U.K.) as a Research Associate with support from EPSRC (EP/E02761X/1) for the period January 2007 - January 2010 and support from a European Commission FP6 Marie-Curie Intra-European Fellowship (EU FP6 IEF 025509 GASO) for the period January 2006 - January 2007. From January 2006 until December 2009, I was the weekly seminar organiser for the Cambridge University Control Group. From June to December 2005, I worked as Senior DSP Engineer at Philips Applied Technologies. I received my electrical engineering degree (with a speciality in electronics) in June 2000 and my Ph.D. degree (in Applied Sciences with a focus on Analysis and Control of Nonlinear Dynamical Systems) in March 2005, both from the University of Liège, Belgium. During my PhD, I mainly worked in the Nonlinear Systems and Control group at the Systems and Modeling research unit of the University of Liège and was supported by a PhD Research Fellowship from the F.N.R.S. (the Belgian National Fund for Scientific Research).

研究领域

I am passionate about developing new concepts and methods and applying the produced results to real-life problems. Currently, my main research interests are: Nonlinear Dynamical Systems Analysis and Control, Synthetic Biology, Systems Biology. I am currently interested in the modelling, analysis, design, control, and implementation of cellular systems (in particular biomolecular feedback systems and gene regulatory networks); and in applications of systems and control engineering methods to the problem of robustly and optimally controlling natural or synthetic biology systems, e.g., robust control of gene regulation networks or optimal drug cocktails scheduling for chronic-like diseases treatments (e.g. cancer and HIV).

近期论文

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Pan W, Menolascina F, Stan G, Online Model Selection for Synthetic Gene Networks, IEEE Conference on Decision and Control, Publisher: IEEE Borkowski O, Ceroni F, Stan GB, Ellis Tet al., 2016, Overloaded and stressed: whole-cell considerations for bacterial synthetic biology., Curr Opin Microbiol, Vol: 33, Pages: 123-130 Kuntz J, Ottobre M, Stan G-B, Barahona Met al., 2016, Bounding stationary averages of polynomial diffusions via semidefinite programming Pan W, Yuan Y, Goncalves J, Stan G-Bet al., 2016, A Sparse Bayesian Approach to the Identification of Nonlinear State-Space Systems, IEEE TRANSACTIONS ON AUTOMATIC CONTROL, Vol: 61, Pages: 182-187, ISSN: 0018-9286 Sootla A, Oyarzun D, Angeli D, Stan G-Bet al., 2016, Shaping pulses to control bistable systems: Analysis, computation and counterexamples, AUTOMATICA, Vol: 63, Pages: 254-264, ISSN: 0005-1098 Ceroni F, Algar R, Stan G-B, Ellis Tet al., 2015, Quantifying cellular capacity identifies gene expression designs with reduced burden, NATURE METHODS, Vol: 12, Pages: 415-+, ISSN: 1548-7091 Dickens L, Caldas B, Schoenhense B, Stan G-B, Faisal AAet al., 2015, The Moveable Feast of Predictive Reward Discounting in Humans, 2nd Multi-disciplinary Conference on Reinforcement Learning and Decision Making (RLDM) Hancock EJ, Stan G-B, Arpino JAJ, Papachristodoulou Aet al., 2015, Simplified mechanistic models of gene regulation for analysis and design, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689 Kelwick R, Kopniczky M, Bower I, Chi W, Chin MHW, Fan S, Pilcher J, Strutt J, Webb AJ, Jensen K, Stan G-B, Kitney R, Freemont Pet al., 2015, A Forward-Design Approach to Increase the Production of Poly-3-Hydroxybutyrate in Genetically Engineered Escherichia coli, PLOS ONE, Vol: 10, ISSN: 1932-6203 Oyarzun DA, Lugagne J-B, Stan G-BV, 2015, Noise Propagation in Synthetic Gene Circuits for Metabolic Control, ACS SYNTHETIC BIOLOGY, Vol: 4, Pages: 116-125, ISSN: 2161-5063 Pan W, Yuan Y, Ljung L, Gonçalves JM, Stan G-Bet al., 2015, Identifying biochemical reaction networks from heterogeneous datasets., Publisher: IEEE, Pages: 2525-2530 Pan W, Yuan Y, Ljung L, Gonçalves JM, Stan G-Bet al., 2015, Identifying Biochemical Reaction Networks From Heterogeneous Datasets., CoRR, Vol: abs/1509.05153 Pan W, Yuan Y, Sandberg H, Goncalves J, Stan G-Bet al., 2015, Online fault diagnosis for nonlinear power systems, AUTOMATICA, Vol: 55, Pages: 27-36, ISSN: 0005-1098 Quinn JY, Cox RS, Adler A, Beal J, Bhatia S, Cai Y, Chen J, Clancy K, Galdzicki M, Hillson NJ, Le Novere N, Maheshwari AJ, McLaughlin JA, Myers CJ, Umesh P, Pocock M, Rodriguez C, Soldatova L, Stan G-BV, Swainston N, Wipat A, Sauro HMet al., 2015, SBOL Visual: A Graphical Language for Genetic Designs, PLOS BIOLOGY, Vol: 13, ISSN: 1545-7885 Sootla A, Oyarzún DA, Angeli D, Stan G-Bet al., 2015, Shaping pulses to control bistable biological systems., Publisher: IEEE, Pages: 3138-3143 Sootla A, Oyarzun D, Angeli D, Stan G-Bet al., 2015, Shaping Pulses to Control Bistable Biological Systems., American Control Conference, Publisher: IEEE, Pages: 3138-3143, ISSN: 0743-1619 Wright O, Delmans M, Stan G-B, Elis Tet al., 2015, Gene Guard: A Modular Plasnnid System Designed for Biosafety, ACS SYNTHETIC BIOLOGY, Vol: 4, Pages: 307-316, ISSN: 2161-5063 Algar RJR, Ellis T, Stan G-B, 2014, Modelling essential interactions between synthetic genes and their chassis cell, IEEE 53rd Annual Conference on Decision and Control (CDC), Publisher: IEEE, Pages: 5437-5444 Galdzicki M, Clancy KP, Oberortner E, Pocock M, Quinn JY, Rodriguez CA, Roehner N, Wilson ML, Adam L, Anderson JC, Bartley BA, Beal J, Chandran D, Chen J, Densmore D, Endy D, Gruenberg R, Hallinan J, Hillson NJ, Johnson JD, Kuchinsky A, Lux M, Misirli G, Peccoud J, Plahar HA, Sirin E, Stan G-B, Villalobos A, Wipat A, Gennari JH, Myers CJ, Sauro HMet al., 2014, The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology, NATURE BIOTECHNOLOGY, Vol: 32, Pages: 545-550, ISSN: 1087-0156 Pan W, Sootla A, Stan G-B, 2014, Distributed Reconstruction of Nonlinear Networks: An ADMM Approach., CoRR, Vol: abs/1403.7429