Schultz, Simon - Imperial College London - Department of Bioengineering

个人简介

I have been at Imperial College since 2004, as head of the Neural Coding Laboratory in the Department of Bioengineering. My first degrees were in Electrical & Computer Systems Engineering, and Physics, from Monash University in Australia. I obtained my D.Phil. in the area of computational neuroscience, under Prof Edmund Rolls at Oxford. I then undertook postdoctoral research in experimental neuroscience at New York University (with Tony Movshon) and University College London (with Michael Häusser).

研究领域

My main interest is in "reverse engineering" the information processing architecture of the brain. Specifically, I investigate the basic principles of information processing in cortical circuits. I take an "engineering approach" which involves both doing experiments (in mice), together with theoretical work to help us understand the data from these experiments. On the experimental side, we use two-photon microscopy, optogenetics and electrophysiology to measure (and perturb) patterns of neuronal activity in vivo. On the theoretical side, we develop new algorithms for analysing the resulting data (particularly making use of Information Theory), and develop models to help us interpret it. I believe that understanding the functional principles of cortical circuits is crucial to understanding, and treating, the effects of brain disorders. I am particularly interested in changes in cortical circuit properties during dementias such as Alzheimer's Disease, and have recently launched a project in my laboratory focussed on this.

近期论文

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Berditchevskaia A, Caze RD, Schultz SR, 2016, Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Cheung K, Schultz SR, Luk W, 2016, NeuroFlow: A General Purpose Spiking Neural Network Simulation Platform using Customizable Processors, FRONTIERS IN NEUROSCIENCE, Vol: 9, ISSN: 1662-453X Evans BD, Jarvis S, Schultz SR, Nikolic Ket al., 2016, PyRhO: A Multiscale Optogenetics Simulation Platform, FRONTIERS IN NEUROINFORMATICS, Vol: 10, ISSN: 1662-5196 Schultz SR, Copeland CS, Foust AJ, Quicke P, Schuck Ret al., 2016, Advances in Two-Photon Scanning and Scanless Microscopy Technologies for Functional Neural Circuit Imaging, Proceedings of the IEEE, Vol: PP, ISSN: 0018-9219 Tang J, Jimenez SCA, Chakraborty S, Schultz SRet al., 2016, Visual Receptive Field Properties of Neurons in the Mouse Lateral Geniculate Nucleus, PLOS ONE, Vol: 11, ISSN: 1932-6203 Yousif N, Fu RZ, Bourquin BA-E-E, Bhrugubanda V, Schultz SR, Seemungal BMet al., 2016, Dopamine Activation Preserves Visual Motion Perception Despite Noise Interference of Human V5/MT, JOURNAL OF NEUROSCIENCE, Vol: 36, Pages: 9303-9312, ISSN: 0270-6474 Cheung K, Schultz SR, Luk W, 2015, NeuroFlow: A General Purpose Spiking Neural Network Simulation Platform using Customizable Processors., Front Neurosci, Vol: 9, ISSN: 1662-4548 Hallett E, Woodward R, Schultz S, Vaidyanathan Ret al., 2015, Rapid Bicycle Gear Switching Based on Physiological Cues, IEEE International Conference on Automation Science and Engineering (CASE), Publisher: IEEE, Pages: 377-382 Jarvis S, Schultz SR, 2015, Prospects for Optogenetic Augmentation of Brain Function., Front Syst Neurosci, Vol: 9 Reynolds S, Onativia J, Copeland CS, Schultz SR, Dragotti PLet al., 2015, Spike Detection Using FRI Methods and Protein Calcium Sensors: Performance Analysis and Comparisons, International Conference on Sampling Theory and Applications (SampTA), Publisher: IEEE, Pages: 533-537 Schuck R, Quicke P, Copeland C, Garasto S, Annecchino LA, Hwang JK, Schultz SRet al., 2015, Rapid three dimensional two photon neural population scanning, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 5867-5870, ISSN: 1557-170X Tolkiehn M, Schultz SR, 2015, Multi-Unit Activity contains information about spatial stimulus structure in mouse primary visual cortex, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 3771-3774, ISSN: 1557-170X Jarvis SJ, Nikolic K, Schultz SR, 2014, Optical coactivation in cortical cells: reprogramming the excitation-inhibition balancing act to control neuronal gain in abstract and detailed models, BMC Neuroscience, Vol: 15, Pages: F1-F1, ISSN: 1471-2202 Longden KD, Muzzu T, Cook DJ, Schultz SR, Krapp HGet al., 2014, Nutritional State Modulates the Neural Processing of Visual Motion, CURRENT BIOLOGY, Vol: 24, Pages: 890-895, ISSN: 0960-9822 Ruz ID, Schultz SR, 2014, Localising and classifying neurons from high density MEA recordings, JOURNAL OF NEUROSCIENCE METHODS, Vol: 233, Pages: 115-128, ISSN: 0165-0270 Schuck R, Annecchino LA, Schultz SR, 2014, Scaling Up Multiphoton Neural Scanning: the SSA algorithm, Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE, Pages: 2837-2840, ISSN: 1557-170X Caze RD, Humphries MD, Gutkin B, Schultz SRet al., 2013, A difficult classification for neurons without dendrites, 6th International IEEE EMBS Conference on Neural Engineering (NER), Publisher: IEEE, Pages: 215-218, ISSN: 1948-3546 Grossman N, Simiaki V, Martinet C, Toumazou C, Schultz SR, Nikolic Ket al., 2013, The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials, JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol: 34, Pages: 477-488, ISSN: 0929-5313 Montani F, Phoka E, Portesi M, Schultz SRet al., 2013, Statistical modelling of higher-order correlations in pools of neural activity, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, Vol: 392, Pages: 3066-3086, ISSN: 0378-4371