Jr, James Moore - Imperial College London - Department of Bioengineering

个人简介

Dr. Moore was born in Toccoa, Georgia, and received his Bachelor of Mechanical Engineering in 1987, his Master of Science in Mechanical Engineering in 1988 and his Ph.D. in 1991, all from the Georgia Institute of Technology. He was the first PhD student of Dr. David N. Ku, MD PhD, and his thesis work was a collaborative project with vascular surgeon Dr. Christopher Zarins and vascular pathologist Dr. Seymour Glagov. He had postdoctoral training at the Swiss Institute of Technology at Lausanne, 1991 – 1994, where he also helped set up a new biomedical engineering lab. From 1994 - 2003 Dr. Moore served as a professor of Mechanical and Biomedical Engineering, Florida International University. He moved to Texas A&M University in 2003, where he served as the Carolyn S. and Tommie E. Lohman ’59 Professor of Biomedical Engineering and Director of Graduate Studies. In Jaunary 2013, he joined Imperial College as the Bagrit and Royal Academy of Engineering Chair in Medical Device Design, and Director of Research for the Department of Bioengineering. Dr. Moore’s research interests include Cardiovascular Biomechanics, Stents, Implantable Devices, Atherosclerosis, and the Lymphatic System. His research focuses on the role of biomechanics in the formation and treatment of diseases such as atherosclerosis and cancer. His cardiovascular biomechanics research includes the first finite element models of artery walls to include residual stress, the first studies of the effects of combined flow and stretch on vascular endothelium, early work on the effects of myocardial contraction on coronary artery flow patterns, and the first studies of the effects of stents on both blood flow patterns and artery wall stress. This work resulted in the development of two novel stent designs aimed at optimizing post-implant biomechanics for the prevention of restenosis, as well as new testing devices for implants that employ more physiologic mechanical forces (currently marketed by Bose). His work on the effects of stretch gradients on cells was awarded best paper of the year in the Journal of Biomechanical Engineering for 2011. In collaboration with Dr. Kumbakonam Rajagopal, he developed constitutive models of strain-accelerated degradation of polymers used in medical implants. His research on lymphatic system biomechanics, initiated in 2004 with Dr. David Zawieja, has provided unprecedented insight into the pumping characteristics of the system and the transport of nitric oxide, antigens, and chemokines in lymphatic tissues. He is currently developing two technologies for preventing and resolving secondary lymphedema, which typically forms subsequent to cancer surgery. Along with his funding from government, charity, and industry sources, Dr. Moore has received multiple patents for medical devices and testing equipment. Dr. Moore has also co-founded two startup companies.

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Bertram CD, Macaskill C, Moore Jr JE, Pump function curve shape for a model lymphatic vessel, Medical Engineering & Physics, ISSN: 1873-4030 Jamalian S, Davis MJ, Zawieja DC, Moore JEet al., 2016, Network Scale Modeling of Lymph Transport and Its Effective Pumping Parameters, PLOS ONE, Vol: 11, Pages: e0148384-e0148384 Jafarnejad M, Woodruff MC, Zawieja DC, Carroll MC, Moore JEet al., 2015, Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes, LYMPHATIC RESEARCH AND BIOLOGY, Vol: 13, Pages: 234-247, ISSN: 1539-6851 Wilson JT, van Loon R, Wang W, Zawieja DC, Moore JEet al., 2015, Determining the combined effect of the lymphatic valve leaflets and sinus on resistance to forward flow, JOURNAL OF BIOMECHANICS, Vol: 48, Pages: 3584-3590, ISSN: 0021-9290 Bertram CD, Macaskill C, Moore JE, 2014, Incorporating measured valve properties into a numerical model of a lymphatic vessel, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, Vol: 17, Pages: 1519-1534, ISSN: 1025-5842 Moore J, Maitland DJ, 2013, Biomedical Technology and Devices, Second Edition, Publisher: CRC PressI Llc, ISBN: 9781439859599 Davis MJ, Moore JE, Zawieja DC, Gahsev AA, Scallan JPet al., 2012, Lymphatic valve lock in response to modest gravitational loads: a contributing mechanism to peripheral lymphedema?, Experimental Biology Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638 Rahbar E, Weimer J, Gibbs H, Yeh AT, Bertram CD, Davis MJ, Hill MA, Zawieja DC, Moore JEet al., 2012, Passive Pressure-Diameter Relationship and Structural Composition of Rat Mesenteric Lymphangions, LYMPHATIC RESEARCH AND BIOLOGY, Vol: 10, Pages: 152-163, ISSN: 1539-6851 Bertram CD, Macaskill C, Moore JE, 2011, Simulation of a Chain of Collapsible Contracting Lymphangions With Progressive Valve Closure, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 133, ISSN: 0148-0731 Davis MJ, Rahbar E, Gashev AA, Zawieja DC, Moore JEet al., 2011, Determinants of valve gating in collecting lymphatic vessels from rat mesentery, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 301, Pages: H48-H60, ISSN: 0363-6135 Rahbar E, Moore JE, 2011, A model of a radially expanding and contracting lymphangion, JOURNAL OF BIOMECHANICS, Vol: 44, Pages: 1001-1007, ISSN: 0021-9290 Rahbar E, Mori D, Moore JE, 2011, Three-dimensional Analysis of Flow Disturbances Caused by Clots in Inferior Vena Cava Filters, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 22, Pages: 835-842, ISSN: 1051-0443 Richardson WJ, Metz RP, Moreno MR, Wilson E, Moore JEet al., 2011, A Device to Study the Effects of Stretch Gradients on Cell Behavior, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 133, ISSN: 0148-0731 Timmins LH, Miller MW, Clubb FJ, Moore JEet al., 2011, Increased artery wall stress post-stenting leads to greater intimal thickening, LABORATORY INVESTIGATION, Vol: 91, Pages: 955-967, ISSN: 0023-6837 Davis MJ, Moore JE, Zawieja DC, Gahsev AA, Scallan JPet al., 2010, Lymphatic valve lock in response to modest gravitational loads: a contributing mechanism to peripheral lymphedema?, FASEB JOURNAL, Vol: 24, ISSN: 0892-6638 Meyer CA, Guivier-Curien C, Moore JE, 2010, Trans-Thrombus Blood Pressure Effects in Abdominal Aortic Aneurysms, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 132, ISSN: 0148-0731 Moore JE, 2010, PUMPING CHARACTERISTICS OF THE LYMPHATIC SYSTEM, ASME 1st Global Congress on Nanoengineering for Medicine and Biology, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 257-258 Moore JE, Timmins LH, LaDisa JF, 2010, Coronary Artery Bifurcation Biomechanics and Implications for Interventional Strategies, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 76, Pages: 836-843, ISSN: 1522-1946 Rahbar E, Placette BA, Moore JE, 2010, MODELING OF LYMPHATIC CONTRACTILITY, 12th ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 657-658