Lee, Chiu Fan - Imperial College London - Department of Bioengineering

研究领域

My research interest is in the theoretical understanding of self-organisation phenomena and pattern formation in biological systems. Specific examples include protein amyloid self-assembly, cytoplasmic pattern formation, tissue homeostasis, and collective behaviour in living organisms. I employ tools of statistical mechanics, soft condensed matter physics, applied mathematics, and computation methods in my research. My work is typically performed in close collaboration with experimental biologists.

近期论文

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Chen L, Lee CF, Toner J, 2016, Mapping two-dimensional polar active fluids to two-dimensional soap and one-dimensional sandblasting., Nat Commun, Vol: 7 Jean L, Lee CF, Hodder P, Hawkins N, Vaux DJet al., 2016, Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide, Scientific Reports, Vol: 6, ISSN: 2045-2322 Lee CF, Pruessner G, 2016, Percolation mechanism drives actin gels to the critically connected state, PHYSICAL REVIEW E, Vol: 93, ISSN: 2470-0045 Pruessner G, Lee CF, 2016, Comment on "Anomalous Discontinuity at the Percolation Critical Point of Active Gels", PHYSICAL REVIEW LETTERS, Vol: 116, ISSN: 0031-9007 Chen L, Toner J, Lee CF, 2015, Critical phenomenon of the order-disorder transition in incompressible active fluids, NEW JOURNAL OF PHYSICS, Vol: 17, ISSN: 1367-2630 Fan Lee C, 2015, Thermal breakage of a semiflexible polymer: breakage profile and rate, Journal of Physics: Condensed Matter, Vol: 27, Pages: 275101-275101, ISSN: 0953-8984 Peng T, Paramelle D, Sana B, Lee CF, Lim Set al., 2014, Designing Non-Native Iron-Binding Site on a Protein Cage for Biological Synthesis of Nanoparticles, SMALL, Vol: 10, Pages: 3131-3138, ISSN: 1613-6810 Sartori P, Granger L, Lee CF, Horowitz JMet al., 2014, Thermodynamic costs of information processing in sensory adaptation, PLoS Computational Biology, Vol: 10, ISSN: 1553-734X Lee CF, 2013, Active particles under confinement: aggregation at the wall and gradient formation inside a channel, NEW JOURNAL OF PHYSICS, Vol: 15, ISSN: 1367-2630 Lee CF, Brangwynne CP, Gharakhani J, Hyman AA, Juelicher Fet al., 2013, Spatial Organization of the Cell Cytoplasm by Position-Dependent Phase Separation, PHYSICAL REVIEW LETTERS, Vol: 111, ISSN: 0031-9007 Lee CF, Brangwynne CP, Gharakhani J, Hyman AA, Jülicher Fet al., 2013, Erratum: Spatial organization of the cell cytoplasm by position-dependent phase separation (Physical Review Letters (2013) 111 (088101)), Physical Review Letters, Vol: 111, ISSN: 0031-9007 Peruani F, Lee CF, 2013, Fluctuations and the role of collision duration in reaction-diffusion systems, EPL, Vol: 102, ISSN: 0295-5075 Trigg BJ, Lee CF, Vaux DJ, Jean Let al., 2013, The air-water interface determines the outcome of seeding during amyloidogenesis, BIOCHEMICAL JOURNAL, Vol: 456, Pages: 67-80, ISSN: 0264-6021 Jean L, Lee CF, Vaux DJ, 2012, Enrichment of Amyloidogenesis at an Air-Water Interface, BIOPHYSICAL JOURNAL, Vol: 102, Pages: 1154-1162, ISSN: 0006-3495 Lee CF, 2012, Length distribution of stiff, self-assembled polymers at thermal equilibrium, JOURNAL OF PHYSICS-CONDENSED MATTER, Vol: 24, ISSN: 0953-8984 Lee CF, Bird S, Shaw M, Jean L, Vaux DJet al., 2012, Combined Effects of Agitation, Macromolecular Crowding, and Interfaces on Amyloidogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 287, ISSN: 0021-9258 Lee CF, 2011, Singular perturbation analysis of a reduced model for collective motion: A renormalization group approach, PHYSICAL REVIEW E, Vol: 83, ISSN: 1539-3755 Smith DMD, Onnela J-P, Lee CF, Fricker MD, Johnson NFet al., 2011, NETWORK AUTOMATA: COUPLING STRUCTURE AND FUNCTION IN DYNAMIC NETWORKS, ADVANCES IN COMPLEX SYSTEMS, Vol: 14, Pages: 317-339, ISSN: 0219-5259 Jean L, Lee CF, Lee C, Shaw M, Vaux DJet al., 2010, Competing discrete interfacial effects are critical for amyloidogenesis, FASEB JOURNAL, Vol: 24, Pages: 309-317, ISSN: 0892-6638 Lee CF, 2010, Predicting rare events in chemical reactions: Application to skin cell proliferation, PHYSICAL REVIEW E, Vol: 82, ISSN: 1539-3755