LADAME, Sylvain - Imperial College London - Department of Bioengineering

个人简介

Dr Sylvain Ladame received his Ph.D. in Chemistry of biomolecules in 2001 from the University of Toulouse, France. He then worked for five years in the group of Pr Shankar Balasubramanian at the Chemistry Department of the University of Cambridge (U.K.) where he developed an interest in the molecular recognition of nucleic acids. In 2006, he joined the CNRS and the Institut de Science et d’Ingénierie Supramoléculaires (ISIS) at the University of Strasbourg, France, where he created the junior research laboratory of Chemistry of Biomolecules. In July 2010, he has been appointed Lecturer in Biosensor Development at the Department of Bioengineering of Imperial College. Dr Ladame has been working in the field of nucleic acid ligands and probes for almost ten years and has published over 30 papers in this field. His current interests deal with the engineering of small molecules and proteins for sensing and targeting nucleic acid structures in vivo. Dr Ladame's group aims to develop original chemical and biochemical tools to explore key biological processess (e.g. DNA transcription, DNA damage repair mechanisms), focusing on the identification of new therapeutic targets and of disease-related biomarkers.

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Metcalf GAD, Shibakawa A, Patel H, Sita-Lumsden A, Zivi A, Rama N, Bevan CL, Ladame Set al., 2016, Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer Diagnosis, ANALYTICAL CHEMISTRY, Vol: 88, Pages: 8091-8098, ISSN: 0003-2700 Panich S, Sleiman MH, Steer I, Ladame S, Edel JBet al., 2016, Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing, ACS Sensors, Vol: 1, Pages: 1097-1102, ISSN: 2379-3694 Zuffo M, Doria F, Spalluto V, Ladame S, Freccero Met al., 2015, Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 21, Pages: 17596-17600, ISSN: 0947-6539 Choi Y, Metcalf G, Sleiman MH, Vair-Turnbull D, Ladame Set al., 2014, Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 22, Pages: 4395-4398, ISSN: 0968-0896 Fallah-Araghi A, Meguellati K, Baret J-C, El Harrak A, Mangeat T, Karplus M, Ladame S, Marques CM, Griffiths ADet al., 2014, Enhanced Chemical Synthesis at Soft Interfaces: A Universal Reaction-Adsorption Mechanism in Microcompartments, PHYSICAL REVIEW LETTERS, Vol: 112, ISSN: 0031-9007 Sleiman MH, Ladame S, 2014, Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 5288-5290, ISSN: 1359-7345 Meguellati K, Fallah-Araghi A, Baret J-C, El Harrak A, Mangeat T, Marques CM, Griffiths AD, Ladame Set al., 2013, Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 11332-11334, ISSN: 1359-7345 Najah M, Mayot E, Mahendra-Wijaya IP, Griffiths AD, Ladame S, Drevelle Aet al., 2013, New Glycosidase Substrates for Droplet-Based Microfluidic Screening, ANALYTICAL CHEMISTRY, Vol: 85, Pages: 9807-9814, ISSN: 0003-2700 Percivalle C, Bartolo J-F, Ladame S, 2013, Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 11, Pages: 16-26, ISSN: 1477-0520 Percivalle C, Mahmood T, Ladame S, 2013, Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters, MEDCHEMCOMM, Vol: 4, Pages: 211-215, ISSN: 2040-2503 Mahmood T, Wu Y, Loriot D, Kuimova M, Ladame Set al., 2012, Closing the Ring to Bring Up the Light: Synthesis of a Hexacyclic Acridinium Cyanine Dye, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 12349-12356, ISSN: 0947-6539 Meguellati K, Ladame S, 2012, Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity, CONSTITUTIONAL DYNAMIC CHEMISTRY, Vol: 322, Pages: 291-314, ISSN: 0340-1022 Meguellati K, Ladame S, Spichty M, 2011, A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes, DYES AND PIGMENTS, Vol: 90, Pages: 114-118, ISSN: 0143-7208 Koripelly G, Meguellati K, Ladame S, 2010, Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes, BIOCONJUGATE CHEMISTRY, Vol: 21, Pages: 2103-2109, ISSN: 1043-1802 Mahmood T, Paul A, Ladame S, 2010, Synthesis and Spectroscopic and DNA-Binding Properties of Fluorogenic Acridine-Containing Cyanine Dyes, JOURNAL OF ORGANIC CHEMISTRY, Vol: 75, Pages: 204-207, ISSN: 0022-3263 Meguellati K, Koripelly G, Ladame S, 2010, DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 2738-2742, ISSN: 1433-7851 Meguellati K, Spichty M, Ladame S, 2010, Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts, MOLECULAR BIOSYSTEMS, Vol: 6, Pages: 1694-1699, ISSN: 1742-206X Meguellati K, Spichty M, Ladame S, 2009, Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes, ORGANIC LETTERS, Vol: 11, Pages: 1123-1126, ISSN: 1523-7060 Paul A, Ladame S, 2009, 9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo, ORGANIC LETTERS, Vol: 11, Pages: 4894-4897, ISSN: 1523-7060 Redman JE, Granadino-Roldan JM, Schouten JA, Ladame S, Reszka AP, Neidle S, Balasubramanian Set al., 2009, Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 7, Pages: 76-84, ISSN: 1477-0520