Krams, Rob - Imperial College London - Department of Bioengineering

个人简介

Professor Krams holds a Chair in Molecular Bioengineering at Imperial College, London. Prior to joining Imperial College he worked as Associate Professor in the department Bioengineering, Thoraxcentre Rotterdam, the Netherlands and as associate professor/chair in the department of Medical Physics, Free University in Amsterdam. He received his Medical Degree and Ph.D. from the Free University, Amsterdam in 1989. His research is focussed on the molecular mechanism underlying biomechanical stimuli. To that end he uses a combination of engineering techniques (imaging, systems biology and synthetic biology) and molecular techniques (high throughput, qPCR, life cell imaging) to study the interaction of gene expression and shear stress and wall stress on cells in culture and in whole animals. It has led to the development of new devices for patient and experimental studies and to the development of new analysis techniques for images obtained by microscopes. The work that will be started up in London consists of imaging of animals and application of system biology and mult-scale modelling to vascular biology.

研究领域

The research in our group consists of a combination of engineering techniques and genomics to study the vascular biology of the vessel wall. To that end, we develop new tools for the induction of complex flow fields, quantification of images, robot driven technologies for genomics and synthetic biology. With this new techniques we perform animal experiments for the testing of new theories of atherosclerosis.

近期论文

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Antonacci G, Pedrigi R, Krams R, Torok Pet al., 2016, Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation), 3rd Conference on Optical Elastography and Tissue Biomechanics III, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Hernandez ADR, Towhidi L, Pedrigi RM, Homma T, Krams Ret al., 2016, Development of a synthetic gene network to modulate gene expression by mechanical forces, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Krams RM, Pedrigi RM, Kis Z, 2016, A novel assay for regulating transcription factors by flow, CARDIOVASCULAR RESEARCH, Vol: 111, Pages: S117-S117, ISSN: 0008-6363 Maimari N, Pedrigi RM, Russo A, Broda K, Krams Ret al., 2016, Integration of flow studies for robust selection of mechanoresponsive genes, THROMBOSIS AND HAEMOSTASIS, Vol: 115, Pages: 474-483, ISSN: 0340-6245 Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R, Monaco Cet al., 2016, "Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques" (vol 89B, pg 168, 2015), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 91, Pages: 10-10, ISSN: 0022-2828 Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M, Krams Ret al., 2016, Comparison between direct and reverse electroporation of cells in situ: a simulation study., Physiol Rep, Vol: 4 Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R, Toeroek Pet al., 2015, Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689 Dent MR, Lopez-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ, Kuimova MKet al., 2015, Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 17, Pages: 18393-18402, ISSN: 1463-9076 Kis Z, Pereira HS, Homma T, Pedrigi RM, Krams Ret al., 2015, Mammalian synthetic biology: emerging medical applications, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689 Pedrigi RM, Poulsen CB, Mehta VV, Holm NR, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G, Mattesini A, Bjorklund MM, Andersen NP, Grondal AK, Petretto E, Foin N, Davies JE, Di Mario C, Bentzon JF, Botker HE, Falk E, Krams R, de Silva Ret al., 2015, Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs, CIRCULATION, Vol: 132, Pages: 1003-1012, ISSN: 0009-7322 Pereira GDC, Krams R, 2015, FLOW CHARACTERISTICS ENHANCED BY THE COMPLIANT ARTERIES AND THEIR EFFECTS IN VULNERABLE PLAQUE FORMATION, British-Cardiac-Society (BCS) Annual Conference on Hearts and Genes, Publisher: BMJ PUBLISHING GROUP, ISSN: 1355-6037 Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M, Bjorklund MM, Andersen NP, Grondal AK, Nachiappan A, Foin N, Davies JER, Di Mario C, Botker HE, Bentzon JF, Falk E, Krams R, de Silva Ret al., 2015, INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA, Scientific Session of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: A1927-A1927, ISSN: 0735-1097 Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R, Monaco Cet al., 2015, Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 89, Pages: 168-172, ISSN: 0022-2828 Villanueva ME, Pereira HSA, Rajyaguru J, Krams R, Chachuat Bet al., 2015, Bifurcation and stability analysis of nonlinear dynamic systems using complete search, Pages: 627-628 Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P, Coppola Get al., 2014, Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow., J R Soc Interface, Vol: 11 Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H, Evans PCet al., 2014, In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer F-18-FEDAA1106, MOLECULAR IMAGING, Vol: 13, ISSN: 1535-3508 Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG, Krams Ret al., 2014, TRANSCRIPTOME ANALYSIS OF LOCAL SHEAR DEPENDENT GENE EXPRESSION IN ENDOTHELIAL CELLS DURING THIN-CAP FIBROATHEROMA(TCFA) DEVELOPMENT, Autumn Meeting of the British-Atherosclerosis-Society (BAS), Publisher: ELSEVIER IRELAND LTD, Pages: E9-E9, ISSN: 0021-9150 Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A, Krams Ret al., 2014, An In situ electroporation and flow device for mechanotransduction studies, Microarrays: Principles, Applications and Technologies, Pages: 49-67, ISBN: 9781629487137 Kwak BR, Baeck M, Bochaton-Piallat M-L, Caligiuri G, Daemens MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ, Evans PCet al., 2014, Biomechanical factors in atherosclerosis: mechanisms and clinical implications, EUROPEAN HEART JOURNAL, Vol: 35, Pages: 3013-+, ISSN: 0195-668X Maimari N, Broda K, Kakas A, Krams R, Russo Aet al., 2014, Symbolic Representation and Inference of Regulatory Network Structures, Logical Modeling of Biological Systems, Pages: 1-48, ISBN: 9781119005223