Kozlov, Andrei S. - Imperial College London - Department of Bioengineering

个人简介

Dr. Kozlov’s research background is in sensory neuroscience and biophysics. Andrei obtained a PhD from Université Louis Pasteur de Strasbourg in the area of ion channel biophysics. During his first postdoc (ESPCI, Paris) he investigated how astrocytes modulate neural circuits in the central nervous system. Andrei’s research in sensory neuroscience has focused on auditory system. He examined the biophysics of mechanoelectrical transduction in the inner ear (at the Rockefeller University, New York), and investigated computations in auditory cortex (at the University of California, San Diego). Dr. Kozlov joined in 2014 the Department of Bioengineering at Imperial College London, where he founded the Laboratory of Auditory Neuroscience and Biophysics. http://www.kozlovlab.com The lab, broadly speaking, focuses on how the auditory system, a keystone of human communication, achieves its remarkable sensitivity, selectivity, and invariance. We investigate both how the inner ear converts sounds into electrical signals, and how auditory cortex interprets these signals.

研究领域

Our research interests are centred on two areas: how the inner ear converts sounds into electrical signals, and how auditory cortex interprets these signals. We combine optical, mechanical, electrophysiological and computational methods to address questions in auditory neuroscience and biophysics.

近期论文

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Albert J. T. & Kozlov A. S. (2016) Comparative aspects of hearing in vertebrates and insects with antennal ears. Current Biology 26: R1050-R1061 (Invited review). Kozlov A. S*. & Gentner TQ. (2016) Central auditory neurons have composite receptive fields. PNAS. 113(5):1441-6. * corresponding author. Kozlov A. S*. & Gentner TQ. (2014) Central auditory neurons display flexible feature recombination functions. J. Neurophysiol. 111(6): 1183-89. (Featured article). * corresponding author. Kozlov A. S., Andor-Ardo D. & Hudspeth A. J. (2012) Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus. PNAS 109(8): 2896-901. (Featured in the “Scientific Computing World” magazine). Kozlov A. S., Risler T., Hinterwirth A. & Hudspeth A. J. (2012) Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies. J. Physiol. 590: 301-308. (Cover article). Kozlov A. S., Baumgart J., Risler T., Versteegh C. P. & Hudspeth A. J. (2011) Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale. Nature 474: 376-379 (Cover article; also featured in Current Biology, 21, R632-4, 2011). Miranda-Rottmann S., Kozlov A. S. & Hudspeth A. J. (2010) Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient. Mol. Cell Biol. 30(14): 3646-60. (Cover article). Angulo MC., Le Meur K., Kozlov A. S., Charpak S. & Audinat E. (2008) GABA, a forgotten gliotransmitter. Prog. Neurobiol. 86(3): 297-303. Chiappe E., Kozlov A. S. & Hudspeth A.J. (2007) The structural and functional differentiation of hair cells in a lizard's basilar papilla suggests an operational principle of amniote cochleas. J. Neurosci. 27(44): 11978-85. (Featured article). Kozlov A. S., Risler T. & Hudspeth A.J. (2007) Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels. Nature Neuroscience 10: 87-92. (Featured in News&Views). Kozlov A. S., Angulo M. C., Audinat E., Charpak S. (2006) Target cell-specific modulation of neuronal activity by astrocytes. PNAS 103(26):10058-63. Angulo M. C., Kozlov A. S., Charpak S., Audinat E. (2004) Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J. Neurosci. 24(31): 6920-7. Kozlov A. S., McKenna F., Lee J. H., Cribbs L. L., Perez-Reyes E., Feltz A. & Lambert R. C. (1999) Distinct kinetics of cloned T-type Ca2+ channels lead to differential Ca2+ entry and frequency-dependence during mock action potentials. Eur. J. Neurosci. 11(12): 4149-58.