Higgins, Claire - Imperial College London - Department of Bioengineering

个人简介

Dr. Claire Higgins was appointed as a Lecturer in the Department of Bioengineering in April 2014. She joined Imperial after postdoctoral training in the laboratory of Prof. Angela Christiano, in the Department of Dermatology, at Columbia University in New York. At Columbia she received a Career Development Award from the Dermatology Foundation to research the 'Molecular basis of human hair follicle induction'. Claire obtained a Ph.D. in Skin Developmental Biology from Durham University in 2007, and holds a B.Sc. in Natural Sciences. The main focus of the research group is to understand mechanisms of tissue development, and regeneration, both in normal conditions, and in response to disease or injury. The hair follicle is used as a model, as it is an accessible and elegant system to study organ regeneration. Research into developmental, and regenerative processes means we can try and recreate them in a lab setting, and exploit the inherent properties of interacting cells to engineer new tissues and structures. Hair follicles contain specialised cells located in a small mesenchymal compartment at the base of the follicle, termed the dermal papilla. Interaction between the dermal papilla and the bulge (the epithelial stem cell compartment of the follicle), drives the hair follicle cycle. Work in the lab encompasses understanding how these cells acquire their specialised ability to instruct hair growth, in addition to elucidating the role of these cells in response to traumatic injury, and their behaviour during skin repair.

研究领域

Hair follicle development and cycling Tissue regeneration Skin wound healing Inappropriate differentiation during wound repair

近期论文

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Higgins CA, Roger M, Hill R, Ali-Khan AS, Garlick J, Christiano AM, Jahoda CAet al., 2016, Multifaceted role of hair follicle dermal cells in bioengineered skins., Br J Dermatol Topouzi H, Higgins CA, 2016, Changing faces: can a new identity stop balding?, Exp Dermatol, Vol: 25, Pages: 765-766 Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AMet al., 2015, Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells, PLOS ONE, Vol: 10, ISSN: 1932-6203 Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, Christiano AMet al., 2015, Pharmacologic inhibition of JAK-STAT signaling promotes hair growth., Sci Adv, Vol: 1 Topouzi H, Higgins CA, 2015, Expression map of three distinct skin fibroblast populations isolated from human skin, 45th Annual Meeting of the European-Society-for-Dermatological-Research, Publisher: NATURE PUBLISHING GROUP, Pages: S68-S68, ISSN: 0022-202X Eungdamrong NJ, Higgins C, Guo Z, Lee W-H, Gillette B, Sia S, Christiano AMet al., 2014, Challenges and promises in modeling dermatologic disorders with bioengineered skin, Experimental Biology and Medicine, Vol: 239, Pages: 1215-1224, ISSN: 1535-3702 Furniss M, Higgins CA, Martinez-Mir A, Horev L, Petukhova L, Stanimirovic A, Miljkovic J, Zlotogorski A, Christiano AMet al., 2014, Identification of Distinct Mutations in AAGAB in Families with Type 1 Punctate Palmoplantar Keratoderma, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 134, Pages: 1749-1752, ISSN: 0022-202X Higgins CA, 2014, Interrogating the integument: the role of the epidermis in hair induction, EXPERIMENTAL DERMATOLOGY, Vol: 23, Pages: 714-715, ISSN: 0906-6705 Higgins CA, Christiano AM, 2014, Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia, REGENERATIVE MEDICINE, Vol: 9, Pages: 101-111, ISSN: 1746-0751 Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AMet al., 2014, FGF5 is a crucial regulator of hair length in humans, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 111, Pages: 10648-10653, ISSN: 0027-8424 Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L, Singh P, Petukhova L, Mackay-Wiggan J, Christiano AM, Clynes Ret al., 2014, Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition, NATURE MEDICINE, Vol: 20, Pages: 1043-1049, ISSN: 1078-8956 Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AMet al., 2013, Building a microphysiological skin model from induced pluripotent stem cells, STEM CELL RESEARCH & THERAPY, Vol: 4, ISSN: 1757-6512 Higgins CA, Chen JC, Cerise JE, Jahoda CAB, Christiano AMet al., 2013, Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 19679-19688, ISSN: 0027-8424 Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AMet al., 2013, Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs), PLOS ONE, Vol: 8, ISSN: 1932-6203 De Berker D, Higgins CA, Jahoda C, Christiano AMet al., 2012, Biology of Hair and Nails, Dermatology, 3rd Edition, Editors: Bolognia, Jorizzo, Schaffer, Publisher: Elsevier Publishing, ISBN: 9780723435716 Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CAB, Christiano AMet al., 2012, Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 132, Pages: 1725-1727, ISSN: 0022-202X Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CABet al., 2012, Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures, PLOS ONE, Vol: 7, ISSN: 1932-6203 Higgins CA, Westgate GE, Jahoda CAB, 2011, Modulation in Proteolytic Activity Is Identified as a Hallmark of Exogen by Transcriptional Profiling of Hair Follicles, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 131, Pages: 2349-2357, ISSN: 0022-202X Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CABet al., 2010, Modelling the hair follicle dermal papilla using spheroid cell cultures, EXPERIMENTAL DERMATOLOGY, Vol: 19, Pages: 546-548, ISSN: 0906-6705 Higgins CA, Richardson GD, Westgate GE, Jahoda CABet al., 2009, Exogen involves gradual release of the hair club fibre in the vibrissa follicle model, EXPERIMENTAL DERMATOLOGY, Vol: 18, Pages: 793-795, ISSN: 0906-6705