Green, Rylie - Imperial College London - Department of Bioengineering

个人简介

Dr Rylie Green joined the Bioengineering department in 2016. She received her PhD (Biomedical Engineering) from the University of New South Wales, Australia in 2008. Dr Green’s research has been focused on developing bioactive conducting polymers for application to medical electrodes, with a specific focus on vision prostheses and cochlear implants. Specifically, she has been investigating the application of bioactive electrode coating technologies to a developmental bionic eye device (with Bionic Vision Australia), and commercial cochlear implants (with Cochlear Ltd). More recently Dr Green has been working in collaboration with GlaxoSmithKline Bioelectronics, to investigate a patented conductive hydrogel electrode concept, developed to reduce strain mismatch between implants and neural tissue. Dr Green has also tissue engineered “living electrodes” (a DARPA funded project), which will allow neural cells to synaptically interface with bionic devices.

研究领域

bio-interfacial engineering for neuroprosthetics; polymer based electronics; and biomaterials for regenerative medicine. Current bioelectronic devices including the bionic eye, pacemakers, robotic limb prostheses and brain-machine interfaces have the ability to further improve the quality of life for millions of people globally. Key to making these devices effective over extended patient lifetimes and hence commercially viable is the development of advanced materials which improve device functionality. I believe the most important factor is the interface where synthetic device meets the biological environment. To this end, my research aims to understand cell-material interactions and design appropriate material interfaces with bioactive components which will promote intimate integration between tissue and device. Specifically I aim to do this through the design, modification, fabrication and characterisation of polymer systems. My research has been split into three related streams, one which looks at novel forms of conducting materials, one which focuses on characterising new and existing electrode technologies for use in bionic implants and finally a newly emerging area in complex cell cultures for in vitro prediction of in vivo response to neural implants.

近期论文

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Gilmour AD, Woolley AJ, Poole-Warren LA, Thomson CE, Green RAet al., 2016, A critical review of cell culture strategies for modelling intracortical brain implant material reactions, Biomaterials, Vol: 91, Pages: 23-43, ISSN: 1878-5905 Hassarati RT, Foster LJR, Green RA, 2016, Influence of Biphasic Stimulation on Olfactory Ensheathing Cells for Neuroprosthetic Devices., Front Neurosci, Vol: 10, ISSN: 1662-4548 Hassarati RT, Marcal H, John L, Foster R, Green RAet al., 2016, Biofunctionalization of conductive hydrogel coatings to support olfactory ensheathing cells at implantable electrode interfaces, 6th Indo-Australian Conference on Biomaterials, Tissue Engineering, Drug Delivery System and Regenerative Medicine, Publisher: WILEY-BLACKWELL, Pages: 712-722, ISSN: 1552-4973 Patton AJ, Poole-Warren LA, Green RA, 2016, Mechanisms for Imparting Conductivity to Nonconductive Polymeric Biomaterials., Macromol Biosci, Vol: 16, Pages: 1103-1121 Amella AD, Patton AJ, Martens PJ, Lovell NH, Poole-Warren LA, Green RAet al., 2015, Freestanding, soft bioelectronics, Pages: 607-610, ISSN: 1948-3554 Aregueta-Robles UA, Lim KS, Martens PJ, Lovell NH, Poole-Warren LA, Green Ret al., 2015, Producing 3D neuronal networks in hydrogels for living bionic device interfaces, Pages: 2600-2603, ISSN: 1557-170X Gilmour AD, Goding J, Poole-Warren LA, Thomson CE, Green RAet al., 2015, In vitro biological assessment of electrode materials for neural interfaces, Pages: 450-453, ISSN: 1948-3554 Goding J, Green R, Martens P, Poole-Warren Let al., 2015, Bioactive conducting polymers for optimising the neural interface, Biointerfaces : Where Material Meets Biology, Publisher: Royal Society of Chemistry, Pages: 192-220, ISBN: 978-1-78262-845-3 Goding JA, Gilmour AD, Martens PJ, Poole-Warren LA, Green RAet al., 2015, Small bioactive molecules as dual functional co-dopants for conducting polymers, Journal of Materials Chemistry B, Vol: 3, Pages: 5058-5069, ISSN: 2050-750X Green R, Abidian MR, 2015, Conducting Polymers for Neural Prosthetic and Neural Interface Applications., Adv Mater, Vol: 27, Pages: 7620-7637 Green RA, Goding JA, 2015, Biosynthetic conductive polymer composites for tissue-engineering biomedical devices, Biosynthetic Polymers for Medical Applications, Editors: Poole-Warren, Martens, Green, Publisher: Elsevier, Pages: 277-298, ISBN: 9781782421054 Lim KS, Ramaswamy Y, Alves MH, Green RA, Poole-Warren LA, Martens Pet al., 2015, Optimization of crosslinking parameters for biosynthetic poly(Vinyl-alcohol)-tyramine hydrogels, Pages: 284-287, ISSN: 1680-0737 Patton AJ, Green RA, Poole-Warren LA, 2015, Mediating conducting polymer growth within hydrogels by controlling nucleation, APL Materials, Vol: 3, ISSN: 2166-532X Poole-Warren L, Martens P, Green R, 2015, Biosynthetic Polymers for Medical Applications, ISBN: 9781782421139 Aregueta-Robles UA, Woolley AJ, Poole-Warren LA, Lovell NH, Green RAet al., 2014, Organic electrode coatings for next-generation neural interfaces., Front Neuroeng, Vol: 7 Baek S, Green RA, Poole-Warren LA, 2014, The biological and electrical trade-offs related to the thickness of conducting polymers for neural applications., Acta Biomater, Vol: 10, Pages: 3048-3058 Baek S, Green RA, Poole-Warren LA, 2014, Effects of dopants on the biomechanical properties of conducting polymer films on platinum electrodes., J Biomed Mater Res A, Vol: 102, Pages: 2743-2754 Baek S, Green RA, Poole-Warren LA, 2014, The biological and electrical trade-offs related to the thickness of conducting polymers for neural applications, Acta Biomaterialia, Vol: 10, Pages: 3048-3058, ISSN: 1878-7568 Green RA, Matteucci PB, Dodds CW, Palmer J, Dueck WF, Hassarati RT, Byrnes-Preston PJ, Lovell NH, Suaning GJet al., 2014, Laser patterning of platinum electrodes for safe neurostimulation., J Neural Eng, Vol: 11 Hassarati RT, Dueck WF, Tasche C, Carter PM, Poole-Warren LA, Green RAet al., 2014, Improving cochlear implant properties through conductive hydrogel coatings, IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol: 22, Pages: 411-418, ISSN: 1534-4320