Hernandez, ArmandoDel Rio - Imperial College London

个人简介

Dr. Armando E. del Río Hernández is a Senior Lecturer in the Department of Bioengineering at Imperial College London, UK. His research is focused on the field of cellular and molecular mechanotransduction, the study of the mechanisms by which cells and molecules transform mechanical stimuli into biochemical signals. For more information, please click this link. Enquires from motivated and exceptional students and postdocs to work in his group are always welcome. Please send full CV and cover letter to: a.del-rio-hernandez@imperial.ac.uk In the Department of Bioengineering, Dr. del Río Hernández is the Director of the MRes in Bioengineering, which offers the opportunity for graduate students to begin their careers in scientific research.

研究领域

Force is ubiquitous in nature at all levels of organization. At the cellular scale, physical stimuli integrate with biochemical signals to orchestrate the precisely controlled pathways of proteins interaction that govern the fate of cells. A failure or modification of this subtle control mark the onset of numerous human disorders, particularly those that are highly sensitive to mechanical cues such as cardiovascular diseases and cancer. Our research is focused on elucidating the mechanisms through which mechanical forces entwine with chemical signaling to regulate the behavior of cells and molecules in physiological conditions; and how these mechanisms are lost or altered in pathological scenarios. To this end, we use a combination of microscopy, nanotechnology, and cellular and molecular biology approaches.

近期论文

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Robinson B, Rice A, Cortes E, Del Rio Hernandez AEet al., Assessment of extracellular matrix remodeling using 3D Matrigel/collagen matrices and second harmonic generation microscopy, Jove-Journal of Visualized Experiments, ISSN: 1940-087X Sarper M, Lieberthal T, Del Rio Hernandez AE, Elucidating the Effect of Extracellular Matrix Remodeling by Stromal Cells on Pancreatic Cancer Cell Invasion in 3D Organotypic Systems, Jove-Journal of Visualized Experiments, ISSN: 1940-087X Attwood SJ, Cortes E, Haining AWM, Robinson B, Li D, Gautrot J, Hernandez ADRet al., 2016, Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B, Del Río Hernández Aet al., 2016, ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion., Nat Commun, Vol: 7 Haining AW, von Essen M, Attwood SJ, Hytonen VP, del Rio Hernandez Aet al., 2016, All Subdomains of the Talin Rod Are Mechanically Vulnerable and May Contribute to Cellular Mechanosensing, ACS Nano, ISSN: 1936-086X Haining AWM, Lieberthal TJ, Hernandez ADR, 2016, Talin: a mechanosensitive molecule in health and disease, FASEB JOURNAL, Vol: 30, Pages: 2073-2085, ISSN: 0892-6638 Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Hernandez ADR, Towhidi L, Pedrigi RM, Homma T, Krams Ret al., 2016, Development of a synthetic gene network to modulate gene expression by mechanical forces, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322 Robinson BK, Cortes E, Rice AJ, Sarper M, Hernandez ADRet al., 2016, Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells, BIOLOGY OPEN, Vol: 5, Pages: 875-882, ISSN: 2046-6390 Sarper M, Cortes E, Lieberthal T, del Rio Hernandez Aet al., 2016, ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells, Scientific Reports, Vol: 6, ISSN: 2045-2322 Roca-Cusachs P, del Rio A, Puklin-Faucher E, Gauthier NC, Biais N, Sheetz MPet al., 2013, Integrin-dependent force transmission to the extracellular matrix by alpha-actinin triggers adhesion maturation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: E1361-E1370, ISSN: 0027-8424 Roca-Cusachs P, Gauthier NC, del Rio A, Sheetz MPet al., 2009, Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 16245-16250, ISSN: 0027-8424 del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MPet al., 2009, Stretching Single Talin Rod Molecules Activates Vinculin Binding, SCIENCE, Vol: 323, Pages: 638-641, ISSN: 0036-8075 Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I, Ghose Ret al., 2007, Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: Insights into a functional role in intramembrane proteolysis, JOURNAL OF MOLECULAR BIOLOGY, Vol: 365, Pages: 109-122, ISSN: 0022-2836 Del Rio A, Anand A, Ghose R, 2006, Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteins, JOURNAL OF MAGNETIC RESONANCE, Vol: 180, Pages: 1-17, ISSN: 1090-7807 del Rio A, Coto B, Renuncio JAR, Pando Cet al., 2004, Vapor-liquid equilibria for the binary system 2,2-dimethylbutane plus 1,1-dimethylpropyl methyl ether (TAME) at 298.15, 318.15, and 338.15 K, FLUID PHASE EQUILIBRIA, Vol: 221, Pages: 1-6, ISSN: 0378-3812 Segade L, de Llano JJ, Jimenez E, del Rio A, Pando C, Renuncio JARet al., 2003, Vapor-liquid equilibria of propan-1-ol+1,1-dimethylethyl methyl ether (MTBE) mixtures. Experimental results and modeling, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 5, Pages: 2858-2861, ISSN: 1463-9076 Spuhl O, Arlt W, Hernandez AD, 2003, Prediction of thermodynamic material properties with the COSMO-RS continuum model, Meeting of the GVC Specialized committee on Thermal Dismantling of Gas, Publisher: WILEY-V C H VERLAG GMBH, Pages: 58-62, ISSN: 0009-286X de Llano JJ, Segade L, Jimenez E, del Rio A, Renuncio JAR, Pando Cet al., 2003, Vapor-liquid equilibria for the binary system hexan-1-ol plus tert-butyl methyl ether (MTBE) at 298.15, 318.15, and 338.15 K, FLUID PHASE EQUILIBRIA, Vol: 208, Pages: 115-121, ISSN: 0378-3812 del Rio A, Coto B, Pando C, Renuncio JARet al., 2002, Vapor-liquid equilibria for the binary system hexane+1,1-dimethylpropyl methyl ether at 298.15, 308.15, 318.15, and 328.15 K, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 41, Pages: 1364-1369, ISSN: 0888-5885 del Rio A, Coto B, Pando C, Renuncio JARet al., 2002, Vapor-liquid equilibria and excess properties of octane+1,1-dimethylpropyl methyl ether (TAME) mixtures, FLUID PHASE EQUILIBRIA, Vol: 200, Pages: 41-51, ISSN: 0378-3812